The effects of both age and sex on irisin levels in paired plasma and cerebrospinal fluid in healthy humans

Ruan, Qingwei; Huang, Yun; Yang, Lan; Ruan, Jian; Gu, Wei; Zhang, Xixue; Zhang, Ying; Zhang, Wei-Bin; Yu, Zhuowei

doi:10.1016/j.peptides.2019.01.004

Cited by 56 publications

(45 citation statements)

References 33 publications

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“…Gender-differences in irisin levels have been observed: women consistently displaying higher values than men among Saudi children [19], middle-aged Chinese [20] and Japanese adults [21]. The divergent results from studies performed in healthy, non OB, and young population [22,23] may be ascribed to the physiologically higher muscle mass in males compared to females, in the absence of increased excess body fat. Comparative data across genders in elderly Caucasian have not been reported.…”

Section: Discussionmentioning

confidence: 99%

Irisin and markers of metabolic derangement in non-diabetic Caucasian subjects with stage I-II obesity during early aging

et al. 2020

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Irisin concentrations are decreased in subjects with overt diabetes and upregulated in those with obesity or impaired fasting glucose. However, gender-balanced data in older populations, in whom risk factors commonly culminate in overt cardiovascular disease, are scarce. We assessed in non-diabetic Caucasian subjects with stage I-II obesity in the early aging range (50 to 70 years), the relationship between irisin, body composition and markers of metabolic derangement by gender. In 60 (31 women, 29 men) non-diabetics with a body mass index �30 -�40 kg/m 2 , we measured anthropometrics and body composition (Air Displacement Plethysmography). We assayed lipid and glucose profile by routine methods, plasma irisin by ELISA and measured insulin resistance by the HOMA index. Irisin levels were higher in women than in men (161 [105-198]) vs 83 [33-115] ng/ml, P<0.001), and correlated directly with HOMA index in both (rho 0.735, P<0.001 M, rho 0.452, P = 0.011 F). Sex differences were maintained across insulin resistance severity stages. In men, irisin concentrations correlated directly with body mass index (rho 0.755, P<0.001), waist circumference (rho 0.623, P<0.001), fat mass index (rho 0.762, P<0.001), glucose (rho 0.408, P = 0.028), the fatty liver index (rho 0.705, P<0.001) and FINDRISC score (rho 0.536, P = 0.003). Among non-diabetic Caucasian subjects with obesity in the early stages of aging, irisin levels reflect the amount of body fat and insulin resistance severity, independently of between-gender differences in the adipomyokine concentrations and are associated with markers of visceral adiposity in men but not in women. Citation: Campolo J, Corradi E, Rizzardi A, Parolini M, Dellanoce C, Di Guglielmo ML, et al. (2020) Irisin and markers of metabolic derangement in non-diabetic Caucasian subjects with stage I-II obesity during early aging. PLoS ONE 15(2): e0229152. https://doi.org/10.

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Section: Discussionmentioning

confidence: 99%

Irisin and markers of metabolic derangement in non-diabetic Caucasian subjects with stage I-II obesity during early aging

et al. 2020

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“…Telomere length can be predicted by plasma irisin level, and this suggested that age may be negatively associated with irisin level (Rana et al, 2014). Likewise, many epidemiological studies refer to circulating irisin levels growing with age (Mahmoodnia et al, 2016;Ruan et al, 2019). The paradoxical results may be due to researchers using different ELISA kits, which produce varying results, or the inclusion and exclusion criteria set by the researchers differ.…”

Section: Irisin In Bone-muscle Crosstalk During Agingmentioning

confidence: 99%

Bone and Muscle Crosstalk in Aging

Hou

et al. 2020

Front. Cell Dev. Biol.

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Osteoporosis and sarcopenia are two age-related diseases that affect the quality of life in the elderly. Initially, they were thought to be two independent diseases; however, recently, increasing basic and clinical data suggest that skeletal muscle and bone are both spatially and metabolically connected. The term “osteosarcopenia” is used to define a condition of synergy of low bone mineral density with muscle atrophy and hypofunction. Bone and muscle cells secrete several factors, such as cytokines, myokines, and osteokines, into the circulation to influence the biological and pathological activities in local and distant organs and cells. Recent studies reveal that extracellular vesicles containing microRNAs derived from senescent skeletal muscle and bone cells can also be transported and aid in regulating bone-muscle crosstalk. In this review, we summarize the age-related changes in the secretome and extracellular vesicle-microRNAs secreted by the muscle and bone, and discuss their interactions between muscle and bone cells during aging.

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“…37 Gender difference was also found in myokines; circulating levels of irisin, released from contracting muscle and playing a crucial role in improvement of liver steatosis, are significantly lower in the healthy female population than in males. 38,39 These results suggest that the crosstalk between skeletal muscle and liver also differs between males and females and this may be another reason female donors' muscularity had no impact on the outcome after LDLT in this study.…”

Section: Ta B L E 3 Multivariable Analysis Using Various Cutoffs Of Dmentioning

confidence: 62%

The combination of a male donor’s high muscle mass and quality is an independent protective factor for graft loss after living donor liver transplantation

Miyachi

Kaido

Hirata

et al. 2020

American Journal of Transplantation

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Several studies have demonstrated that higher donor age is a strong risk factor for poor graft function or survival after both deceased-donor 1 and living-donor liver transplantation (DDLT and LDLT, respectively). 2,3 This seems to be natural because the liver is an organ strongly affected by aging. 4 However, age itself is a multifactorial phenomenon and, although the vigorous efforts in basic science are now unraveling the mechanism of liver senescence, 4 some ambiguities remain about how aging is associated with impaired liver function and regenerative capacity after liver transplantation. 5,6 Therefore, we suspect that there may be

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The effects of both age and sex on irisin levels in paired plasma and cerebrospinal fluid in healthy humans

Cited by 56 publications

References 33 publications

Irisin and markers of metabolic derangement in non-diabetic Caucasian subjects with stage I-II obesity during early aging

Irisin and markers of metabolic derangement in non-diabetic Caucasian subjects with stage I-II obesity during early aging

Bone and Muscle Crosstalk in Aging

The combination of a male donor’s high muscle mass and quality is an independent protective factor for graft loss after living donor liver transplantation

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