The Effects of Breastfeeding on Serum Asymmetric Dimethylarginine Levels and Body Composition in Children

Abstract

Introduction: The purpose of this work was to investigate the association of serum asymmetric dimethylarginine (ADMA) and high-sensitivity C-reactive protein (hs-CRP) levels with duration of breastfeeding and body composition in children. Patients and Methods: The study group consisted of 88 patients with a median age of 12 months (42 boys, 46 girls), classified as never breastfed or fully breastfed. ADMA and hs-CRP were measured by immunoenzymatic enzyme-linked immunosorbent assay commercial kits. Body composition analysis was performed by bioelectrical impedance. Results: We found significantly higher serum ADMA levels but not serum hs-CRP levels in never breastfed compared with the fully breastfed group ( p < 0.05). Serum ADMA was inversely associated with high-density lipoprotein-cholesterol levels and breastfeeding duration ( p < 0.05). Positive correlation was found between ADMA and body fat mass ( p < 0.05). Conclusions: In never breastfed children, increased ADMA is observed; however, further studies are needed to assess whether breastfeeding duration affects body fat and body composition at older ages.

Assessing inflammation in obese patients using DII dietary inflammatory index – A pilot cross sectional study in Jeddah, Saudi Arabia in the year 2017

“…In contrast, there was a strong relation between duration of breast-feeding for three or more months and lower CRP levels in women. Although there some studies have reported that no significant increases in serum CRP between breastfed participants and those never breastfed [38]. There are several possible explanations, where breastfeeding might influence low-grade inflammation only in people who are predisposed to genetic problem.…”

Body composition indices and cardiovascular risk in type 2 diabetes. CV biomarkers are not related to body composition

“…Scarce data from the literature indicate that ADMA is increased in obesity or the metabolic syndrome [24]. In healthy young adults ADMA showed a positive association with body weight, BMI, WC, WHtR and body FM studied by BIA [25]. A positive correlation was found between ADMA and body mass in healthy 1-year old children [19].…”

Body composition in male rats subjected to early weaning and treated with diet containing flour or flaxseed oil after 21 days until 60 days

“…Optimal nutrition during childhood is critical to support the growth and development during the first 12 months following birth. 16 The current study evaluated rat deprived of breast milk at 14 days, when it begins the consumption of solid food. At this age, pups still breastfeed, but they can survive independently of their mothers.…”