The effects of bromazepam on the early stage of visual information processing (P100)

Puga, Fernanda; Sampaio, Isabel; Veiga, Heloisa; Ferreira, Camila; Cagy, Maurício; Piedade, Roberto; Ribeiro, Pedro

doi:10.1590/s0004-282x2007000600006

Cited by 8 publications

(9 citation statements)

References 20 publications

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“…Last, antipsychotic agents have known effects on neural activation (68, 69). An increase in P100 latency during visual discrimination has previously been shown following an acute dose of bromazepam (70). …”

Section: Introductionmentioning

confidence: 66%

“…Component P100 was measured as the maximal positive deflection between 80 and 120 ms (25) at electrodes O1, OZ, and O2 [established optimal occipital scalp sites; (25, 51, 53, 67, 70)]. Peak latencies and amplitudes from baseline were submitted to repeated measures ANOVA, with task (Mooney and photographic faces) and orientation (upright and inverted) as within-subjects factors.…”

Section: Methodsmentioning

confidence: 99%

“…Thus, more evidence for the ERP correlates of configural face processing, without the potentially confounding positive and negative valence information, is also necessary. Given the established effect of pharmacological agents on neural activation (68–70), individuals prone to psychosis, and medication naïve, provide an ideal method of investigating analogous neural processing deficits (73, 74, 81–85), without concern for medication, and other potential confounds introduced by clinical samples (i.e., long-term hospitalization, social isolation) (82, 86). With this in mind, schizotypy provides a valuable model of investigation.…”

Section: Introductionmentioning

confidence: 99%

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Neurophysiological Correlates of Configural Face Processing in Schizotypy

et al. 2014

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Background: Face processing impairment in schizophrenia appears to be underpinned by poor configural (as opposed to feature-based) processing; however, few studies have sought to characterize this impairment electrophysiologically. Given the sensitivity of event-related potentials to antipsychotic medications, and the potential for neurophysiological abnormalities to serve as vulnerability markers for schizophrenia, a handful of studies have investigated early visual P100 and face-selective N170 in “at risk” populations. However, this is the first known neurophysiological investigation of configural face processing in a non-clinical schizotypal sample.Methods: Using stimuli designed to engage configural processing in face perception (upright and inverted Mooney and photographic faces), P100 and N170 components were recorded in healthy individuals characterized by high (N = 14) and low (N = 14) schizotypal traits according to the Oxford–Liverpool Inventory of Feelings and Experiences.Results: High schizotypes showed significantly reduced N170 amplitudes to inverted photographic faces. Typical N170 latency and amplitude inversion effects (delayed and enhanced N170 to inverted relative to upright photographic faces, and enhanced amplitude to upright versus inverted Mooney faces), were demonstrated by low, but not high, schizotypes. No group differences were shown for P100 analyses.Conclusions: The findings suggest that neurophysiological deficits in processing facial configurations (N170) are apparent in schizotypy, while the early sensory processing (P100) of faces appears intact. This work adds to the mounting evidence for analogous neural processing anomalies at the healthy end of the psychosis continuum.

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Section: Introductionmentioning

confidence: 66%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Neurophysiological Correlates of Configural Face Processing in Schizotypy

et al. 2014

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“…and some studies have shown that it triggers changes in neuropsychological functions such as memory, attention, psychomotor activity, reaction time and alertness 7 . Modafinil has already been used for the treatment of narcolepsy and other sleep disorders 8,9,10 .…”

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confidence: 99%

Alpha power oscillation in the frontal cortex under Bromazepam and Modafinil effects

Aprigio

Adolfo

Bittencourt

et al. 2015

Arq. Neuro-Psiquiatr.

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Objective Our aim was to investigate and compare the neuromodulatory effects of bromazepam (6 mg) and modafinil (200 mg) during a sensorimotor task analyzing the changes produced in the absolute alpha power.Method The sample was composed of 15 healthy individuals exposed to three experimental conditions: placebo, modafinil and bromazepam. EEG data were recorded before, during and after the execution of the task. A three-way ANOVA was applied, in order to compare the absolute alpha power among the factors: Group (control, bromazepam and modafinil) Condition (Pre and Post-drug ingestion) and Moment (pre and post-stimulus).Results Interaction was found between the group and condition factors for Fp1, F4 and F3. We observed a main effect of moment and condition for the Fp2, F8 and Fz electrodes.Conclusion We concluded that drugs may interfere in sensorimotor processes, such as in the performance of tasks carried out in an unpredictable scenario.

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“…We suggest that other potentials involved in the decision making process, as well as the P100, should be investigated under drug influence, since the first phases of information processing are probably more sensitive to pharmacological effects [36][37][38]. …”

Section: Resultsmentioning

confidence: 99%

Effects of modafinil and bromazepam on decision-making: a P300 analysis

Novaes

Bittencourt²,

Adolfo³

et al. 2015

Int Arch Med

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Drug influence on the decision making process has been scarcely studied. Researchers have driven the hypothesis that drugs might cause interference on cortical circuits. The aim of the present study is to evaluate the electrophysiological and behavioral changes occurring in the P300 after ingestion of modafinil (200mg), bromazepam (6mg) and placebo in healthy subjects exposed to a sensorimotor task based on the oddball paradigm. The sample for this study consisted of 10 subjects of both sexes, with ages ranging between 20 and 45, who were submitted to a quantitative electroencephalography. The experimental procedure was carried out in three visits, before and after drug ingestion. The results demonstrated a significant increase in the P300 latency and amplitude for the target condition, when compared to the non-target condition, for all analyzed electrodes. No significant difference was found for group or moment. A statistically significant difference was found for the group variable in the behavioral analysis. Such results suggest that the P300 is a measure, which is not sensitive to drug ingestion. On the other hand, the measure presented certain level of sensitivity when the subjects faced two different conditions in the decision making process orientation.

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The effects of bromazepam on the early stage of visual information processing (P100)

Cited by 8 publications

References 20 publications

Neurophysiological Correlates of Configural Face Processing in Schizotypy

Neurophysiological Correlates of Configural Face Processing in Schizotypy

Alpha power oscillation in the frontal cortex under Bromazepam and Modafinil effects

Effects of modafinil and bromazepam on decision-making: a P300 analysis

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