The effects of caffeine administration on the early stage of bone healing and bone density

Duarte, Poliana Mendes; Marques, Marcelo Rocha; Bezerra, Joyce Pinho; Bastos, Marta Ferreira

doi:10.1016/j.archoralbio.2009.05.001

Cited by 23 publications

(27 citation statements)

References 39 publications

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“…13,14 Regarding the process of bone repair caused by tooth extraction, daily administration of caffeine causes a decrease in bone mineral density and in the percentage of the newly formed bone, resulting in the delay of the whole healing process. 9,10,15 Considering that caffeine is widely consumed and the number of patients with postmenopausal osteoporosis requiring surgical procedures involving bone tissue, such as dental extraction, grafts for bone reconstruction and even the installation of osseointegrated implants is increasing, it is important to clarify the structural changes related to bone repair. Thus, the present study aimed to evaluate, histomorphometrically, the effect of estrogen deficiency caused by ovariectomy in bone defects repair created by tooth extraction in rats subjected to daily treatment with caffeine.…”

Section: Introductionmentioning

confidence: 99%

“…Its effects on bone metabolism are not yet conclusive, but biochemically, acute or chronic use has been associated with increased plasma levels of calcium, as well as mineral excretion in the urine. 10,13 As for the quality and quantity of bone, a detrimental effect has been demonstrated in animals in the initial 15 and final periods of bone repair, mainly due to a decrease in volume 9 and bone mineral density deposited, 10,17 reflecting the increased risk of fractures, osteoporosis, and periodontal disease. 14,18 The mechanisms of action of caffeine on bone remodeling are not entirely clear and may be direct and indirect.…”

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confidence: 99%

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Effects of Caffeine on Bones of Osteoporotic Rats

Macedo

Brentegani

Lacerda

2012

Journal of Caffeine Research

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Introduction: Osteoporosis is defined as a bone mass reduction, reaching a point that is insufficient to maintain the structural integrity of the skeleton, particularly after menopause. Caffeine (CAF) is associated with increased risk of osteoporotic bone fractures and inhibition of osteoblasts proliferation. Objective: The aim of this study was to produce an experimental menopause in ovariectomized (OVX) rats treated with daily caffeine injection and assess the newly formed bone. Methods and Materials: Sixty days after ovariectomy, 84 rats were subjected to extraction of upper right incisor and divided into sham: daily intraperitoneal injection of saline; CAF: daily injection of 1.5% caffeine (0.2 mL/100 g body weight) by the same period; OVX: ovariectomized and daily injection of saline; and OVX + CAF: ovariectomized and daily injection of 1.5% caffeine (0.2 mL/100 g body weight). The animals were killed on 7th, 14th, and 28th days after surgery, and their maxillae were processed for obtaining semiserial sections (5 lm) stained with hematoxylin and eosin. Through an image analysis system, the bone volume and the quality of newly formed bone in the dental socket were evaluated. Results: The histological results showed immature bone trabeculae and large amount of blood clot, and histometric analysis revealed less amount of new bone formation by 40.0% in osteoporotic animals and 61.0% in osteoporotic animals treated with caffeine compared with controls (ANOVA p £ 0.01).

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Effects of Caffeine on Bones of Osteoporotic Rats

Macedo

Brentegani

Lacerda

2012

Journal of Caffeine Research

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“…However, this is controversial in the literature, since in vivo studies have shown that coffee does not stimulate the bone loss [40] [41]. Furthermore, Duarte et al [42] described the positive correlation between caffeine consumption in the early stages of bone healing and the bone loss in rats, but they emphasized that it only occurred when a high daily caffeine intake is administrated. In this case, decaffeinated coffee could be an alternative.…”

Section: Resultsmentioning

confidence: 93%

Antibacterial Effect of Aqueous Extracts and Bioactive Chemical Compounds of <i>Coffea canephora</i> against Microorganisms Involved in Dental Caries and Periodontal Disease

Silva¹,

Iório²,

Lobo³

et al. 2014

AiM

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How to cite this paper: da Silva, F. M., et al. (2014) F. M. da Silva et al. 979(MIC = 2.56 to 1.28 mg/mL). Also, Tg showed bactericide properties against SP (MBC = 2.56 mg/mL), PG (MBC = 2.56 mg/mL), FN (MBC = 10.24 mg/mL), PN (MBC = 5.12 mg/mL), and PI (MBC = 2.56 mg/mL). Although 5-CQA has previously shown activity against Streptococcus mutans, in the present study, it showed no activity against all tested microorganisms. C. canephora extract only showed antibacterial activity against cariogenic microorganisms, not presenting action against periodontal pathogens. It was concluded that trigonelline presented the best effect against all pathogens tested, therefore coffee extracts with higher trigonelline content should be tested against these specific pathogens.

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“…Duarte et al [41] described the correlations between caffeine consumption in the early stages of bone healing and the bone density in rats. It was concluded that a high daily caffeine intake body weight/day) may disturb the early stages of bone healing.…”

Section: Discussionmentioning

confidence: 99%

Use of X-ray microprobe to diagnose bone tissue demineralization after caffeine administration

Tomaszewski¹,

Olchowik²,

Tomaszewska³

et al. 2012

Folia Histochem Cytobiol.

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Abstract:Caffeine is a methylxanthine which permeates the placenta. In studies on animals, it has been shown to produce teratogenic and embryotoxic effects in large doses. The objective of this study was to assess the influence of caffeine on the development of bone tissue, with particular reference to elemental bone composition using an X-ray microprobe. The research was conducted on rats. The fertilized females were randomly divided into an experimental and a control group. The experimental group was given caffeine orally in 30 mg/day doses from the 8 th to the 21 st day of pregnancy, while the control group was given water. The fetuses were used to assess the growth and mineralization of the skeleton. On the basis of double dyeing, a qualitative analysis of the bone morphology and mineralization was conducted. For calcium and potassium analysis, an X-ray microprobe was used. In 67 fetuses from the experimental group, changes in skeleton staining with the alcian-alizarin method were noticed. The frequency of the development of variants in the experimental group was statistically higher. In the experimental group, a significant decrease in the calcium level, as well as an increase in the potassium level, was observed. The X-ray microprobe's undoubted advantage is that is offers a quick qualitative and quantitative analysis of the elemental composition of the examined samples. Employing this new technique may furnish us with new capabilities when investigating the essence of the pathology process.

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The effects of caffeine administration on the early stage of bone healing and bone density

Cited by 23 publications

References 39 publications

Effects of Caffeine on Bones of Osteoporotic Rats

Effects of Caffeine on Bones of Osteoporotic Rats

Antibacterial Effect of Aqueous Extracts and Bioactive Chemical Compounds of <i>Coffea canephora</i> against Microorganisms Involved in Dental Caries and Periodontal Disease

Use of X-ray microprobe to diagnose bone tissue demineralization after caffeine administration

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The effects of caffeine administration on the early stage of bone healing and bone density

Cited by 23 publications

References 39 publications

Effects of Caffeine on Bones of Osteoporotic Rats

Effects of Caffeine on Bones of Osteoporotic Rats

Antibacterial Effect of Aqueous Extracts and Bioactive Chemical Compounds of &lt;i&gt;Coffea canephora&lt;/i&gt; against Microorganisms Involved in Dental Caries and Periodontal Disease

Use of X-ray microprobe to diagnose bone tissue demineralization after caffeine administration

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Antibacterial Effect of Aqueous Extracts and Bioactive Chemical Compounds of <i>Coffea canephora</i> against Microorganisms Involved in Dental Caries and Periodontal Disease