The effects of calcitonin on intervertebral disc degeneration in OVX rats

Zhang, Liu; Wang, Zheyan; Cheng, Tan; Miao, J.; Tian, Faming

doi:10.1016/j.bone.2010.09.165

Cited by 1 publication

(4 citation statements)

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“…Some studies have also been conducted to investigate the role of matrix components in the annulus fibrosus in the degeneration of the intervertebral disc. 17 The inhibits MAPK/Wnt/NF-κB pathway. In order to further explore the protective role of calcitonin, it was necessary to detect calcitonin-regulated upstream pathways.…”

Section: Discussionmentioning

confidence: 99%

“…Calcitonin has been shown to play a protective role against IVDD. [15][16][17]37,38 Previous studies mainly focused on the effect of calcitonin on the regulation of calcium and phosphorus. 15,16,37 Calcitonin regulates the morphological integrity of the cartilage endplate of the vertebral body and affects the biomechanics of IVDD, and subsequently alleviates IVDD.…”

Section: Discussionmentioning

confidence: 99%

“…[10][11][12][13][14] In support of this theory, some recent studies have reported the role of exogenous calcitonin in blocking IVDD degeneration. [15][16][17] The former studies all focused on the ovariectomized osteoporotic animals. The osteogenic effect of calcitonin could preserve the microarchitecture and biomechanical properties of adjacent vertebrae, and finally prevent IVDD.…”

mentioning

confidence: 99%

“…The osteogenic effect of calcitonin could preserve the microarchitecture and biomechanical properties of adjacent vertebrae, and finally prevent IVDD. [15][16][17] Moreover, both Tian et al and Luo et al found that calcitonin could protect ovariectomized rats from IVDD by modifying extracellular matrix metabolism of the intervertebral discs. 15,16 Hence, calcitonin must have a direct protective effect on NPCs.…”

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confidence: 99%

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Calcitonin inhibits intervertebral disc degeneration by regulating protein kinase C

Cheng

et al. 2020

J Cellular Molecular Medi

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Intervertebral disc degeneration (IVDD) is the most critical factor that causes low back pain. Molecular biotherapy is a fundamental strategy for IVDD treatment. Calcitonin can promote the proliferation of chondrocytes, stimulate the synthesis of matrix and prevent cartilage degeneration. However, its effect and the underlying mechanism for IVDD have not been fully revealed. Chondrogenic specific matrix components’ mRNA expression of nucleus pulposus cell (NPC) was determined by qPCR. Protein expression of NPC matrix components and protein kinase C was determined by Western blotting. A rat caudal intervertebral disc degeneration model was established and tested for calcitonin in vivo. IL‐1 induced NPC change via decreasing protein kinase C (PKC)‐ε phosphorylation, while increasing PKC‐δ phosphorylation. Calcitonin treatment could prevent or reverse IL‐1‐induced cellular change on PKC signalling associated with degeneration. The positive effect of calcitonin on IVDD in vivo was verified on a rat caudal model. In summary, this study, for the first time, elucidated the important role of calcitonin in the regulation of matrix components in the nucleus of the intervertebral disc. Calcitonin can delay degeneration of the intervertebral disc nucleus by activating the PKC‐ε pathway and inhibiting the PKC‐δ pathway.

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Section: Discussionmentioning

confidence: 99%