The effects of calcitriol and nicotinamide on residual pancreatic β‐cell function in patients with recent‐onset Type 1 diabetes (IMDIAB XI)

Pitocco, Dario; Crinó, Antonino; Stasio, Enrico Di; Manfrini, Silvia; Guglielmi, Chiara; Spera, S.; Anguissola, Giuseppina Beretta; Visalli, N; Suraci, C; Matteoli, M. C.; Patera, Ippolita Patrizia; Cavallo, Maria Gisella; Bizzarri, Carla; Pozzilli, Paolo

doi:10.1111/j.1464-5491.2006.01921.x

Cited by 117 publications

(82 citation statements)

References 18 publications

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“…This could influence the autoimmue pathology of Type 1 diabetes, and could ameliorate low-grade chronic inflammation that has been implicated in insulin resistance in Type 2 diabetes [11]. Vitamin D may also stimulate insulin release by pancreatic b-cells [12,13]. Elevated parathyroid hormone levels, consequent on low vitamin D levels, have also been implicated in impaired insulin release from pancreatic b-cells [14].…”

Section: Introductionmentioning

confidence: 99%

Effect of vitamin D supplementation on glycaemic control and insulin resistance: a systematic review and meta‐analysis

2012

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Aims To systematically review the evidence for the effect of vitamin D supplementation on glycaemia, insulin resistance, progression to diabetes and complications of diabetes.Methods Systematic review and meta-analysis. We searched databases including MEDLINE, EMBASE and the Cochrane Library for randomized controlled trials comparing vitamin D or analogues with placebo. We extracted data on fasting glucose, glycaemic control, insulin resistance, insulin ⁄ C-peptide levels, micro-and macrovascular outcomes and progression from non-diabetes to diabetes. Studies were assessed independently by two reviewers according to a pre-specified protocol.Results Fifteen trials were included in the systematic review. Trial reporting was of moderate, variable quality. Combining all studies, no significant improvement was seen in fasting glucose, HbA 1c or insulin resistance in those treated with vitamin D compared with placebo. For patients with diabetes or impaired glucose tolerance, meta-analysis showed a small effect on fasting glucose ()0.32 mmol ⁄ l, 95% CI )0.57 to )0.07) and a small improvement in insulin resistance (standard mean difference )0.25, 95% CI )0.48 to )0.03). No effect was seen on glycated haemoglobin in patients with diabetes and no differences were seen for any outcome in patients with normal fasting glucose. Insufficient data were available to draw conclusions regarding micro-or macrovascular events; two trials failed to show a reduction in new cases of diabetes in patients treated with vitamin D.Conclusions There is currently insufficient evidence of beneficial effect to recommend vitamin D supplementation as a means of improving glycaemia or insulin resistance in patients with diabetes, normal fasting glucose or impaired glucose tolerance.Diabet. Med. 29, e142-e150 (2012)

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Section: Introductionmentioning

confidence: 99%

Effect of vitamin D supplementation on glycaemic control and insulin resistance: a systematic review and meta‐analysis

2012

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“…Pittoco et al reported the results of an interventional trial in children with newly diagnosed type 1 diabetes, in which the patients were administered calcitriol or nicotinamide in order to preserve beta-cell function. Even though there was a decrease in the insulin requirements at 3 and 6 months in the calcitriol treated group, at the end of the first year there was no difference between the C-peptide levels or hemoglobin A1c between the two groups (Pitocco et al, 2006). Bizzarri et al investigated whether supplementation with calcitriol in recent onset autoimmune diabetes has a protective effect on the pancreatic beta cells and found that, at the doses used in the study, calcitriol did not confer protection against the autoimmune destruction of the beta cells (Bizzarri et al, 2010).…”

Section: Clinical Studies -Vitamin D and Type 1 Diabetesmentioning

confidence: 90%

Role of Vitamin D in the Pathogenesis and Therapy of Type 1 Diabetes Mellitus

Busta¹,

Alfonso²,

Poretsky³

2011

Type 1 Diabetes - Complications, Pathogenesis, and Alternative Treatments

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“…Here we are limited to small interventions and animal studies. In type 2 diabetes very high doses of 25-(OH)D have been administered, but the data are confusing, whereas in type 1 diabetes 1,25-(OH)2D has mainly been given, with little or no effect on C-peptide preservation in newly diagnosed type 1 patients [7,8]. What about NOD mice?…”

Section: Cyp27b1mentioning

confidence: 99%

Vitamin D and diabetes: the devil is in the D-tails

Mathieu

2010

Diabetologia

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The effects of calcitriol and nicotinamide on residual pancreatic β‐cell function in patients with recent‐onset Type 1 diabetes (IMDIAB XI)

Abstract: At the dosage used, calcitriol has a modest effect on residual pancreatic beta-cell function and only temporarily reduces the insulin dose.

Cited by 117 publications

References 18 publications

Effect of vitamin D supplementation on glycaemic control and insulin resistance: a systematic review and meta‐analysis

Effect of vitamin D supplementation on glycaemic control and insulin resistance: a systematic review and meta‐analysis

Role of Vitamin D in the Pathogenesis and Therapy of Type 1 Diabetes Mellitus

Vitamin D and diabetes: the devil is in the D-tails

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