The effects of calcitriol on falls and fractures and physical performance tests

1α,25-Dihydroxyvitamin D3 Regulates Mitochondrial Oxygen Consumption and Dynamics in Human Skeletal Muscle Cells

“…The differentially expressed mRNAs encode proteins that play significant roles in multiple biochemical pathways involved in muscle contraction and relaxation; extracellular matrix-cell receptor interactions; actin cytoskeleton remodeling; and JAK-STAT, insulin-like (17) 0.014 Reactome p53 pathway (16) 0.014 Panther Interferon-signaling (11) 0.017 Panther Muscle contraction (9) 0.022 Reactome Terpenoid backbone biosynthesis (6) 0.028 KEGG Cell adhesion molecules (24) 0.048 KEGG (27), which showed that treatment of vitamin D-deficient humans with cholecalciferol improves muscle phosphocreatine recovery after exercise, suggesting an effect of 1␣,25(OH) 2 D 3 on the formation of high energy phosphorylated intermediates and mitochondrial function. The increase in the numbers of mitochondria could also account for the increase in cellular OCR.…”

“…The administration of vitamin D 3 has been reported to improve muscle strength in humans (9). Reduced serum 1␣,25(OH) 2 D 3 concentrations have been linked to falls in humans (10,11), and clinical trials have demonstrated salutary effects of ␣calcidol on fall prevention (12). Improvement in muscle fiber size has been documented in elderly subjects treated with 1␣,25(OH) 2 D 3 (13).…”

Recomendações da Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) para o diagnóstico e tratamento da hipovitaminose D

“…In large populational studies, low vitamin D levels are associated with mobility reduction, worsening in mus cular function and this way, an increase in the risk of fall (132,156,164). Vitamin D receptors present high concentrations in several areas of the central nervous system.…”

Calcifediol versus vitamin D3 effects on gait speed and trunk sway in young postmenopausal women: a double-blind randomized controlled trial

“…However, a recent trial-level meta-analysis of clinical trials could not confirm this association based on limited data from three trials that tested gait speed as an endpoint [11]. Of the three trials pooled by Muir and Montero-Odasso, one provided 300,000 IU vitamin D 3 [12], one 20 IU calcitriol [13], and one 400 IU vitamin D 3 in combination with 800 mg calcium [14], and only the latter demonstrated a significant benefit on gait speed. The same meta-analysis demonstrated a significant reduction of postural sway across three trials, which individually showed a nonsignificant benefit (standardized mean difference of −0.20; 95 % confidence interval (CI)=−0.39 to −0.01): one provided 400 IU vitamin D 3 in combination with 800 mg calcium daily [14], one 600,000 IU vitamin D 2 once per year [15], and one 800 IU vitamin D 3 plus 1000 mg of calcium daily [16].…”