The effects of calorie-matched high-fat diet consumption on spontaneous physical activity and development of obesity

Moretto, Thaís Ludmilla; Benfato, Izabelle Dias; Carvalho, Francine Pereira de; Barthichoto, Marcela; Sueur-Maluf, Luciana Le; Oliveira, Camila Aparecida Machado de

doi:10.1016/j.lfs.2017.04.017

Cited by 24 publications

(16 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Overall, obese mice demonstrate reduced spontaneous locomotion [ 8 , 54 ]. Furthermore, some dietary fibers are associated with improved physical performance of certain motor tasks [ 84 ].…”

Section: Discussionmentioning

confidence: 99%

Switching from a high-fat cellulose diet to a high-fat pectin diet reverses certain obesity-related morbidities

et al. 2018

View full text Add to dashboard Cite

BackgroundReducing caloric intake is a proven intervention for mitigating and modulating morbidities associated with overnutrition. Caloric restriction is difficult to affect clinically, therefore, dietary interventions that ameliorate the adverse consequences of overnutrition in the presence of a high-calorie diet would be of value.MethodsMice were fed an obesogenic diet containing 60% fat + 10% cellulose (HFC), or a control diet containing 10% fat + 10% cellulose (LFC) for 12 wks. Subgroups of mice were then switched from HFC to each of the following diets for an additional 5 wks: 1) 60% fat + 10% pectin (HFP), 2) LFC or 3) 10% fat + 10% pectin (LFP). To test for statistical differences, one-way or two-way ANOVAs were used with or without repeated measurements as needed.ResultsIn comparison to HFC, HFP prevented additional weight gain while LFC and LFP triggered weight loss of 22.2 and 25.4%, respectively. Mice continued on HFC experienced a weight increase of 26% during the same 5 wk. interval. After 12 wks, HFC decreased mouse locomotion by 18% when compared to control diet, but a diet switch to LFC or LFP restored mouse movement. Importantly, HFP, LFC, and LFP reduced fasting blood glucose when compared to HFC. Likewise, HFP, LFC and LFP improved glucose tolerance and decreased fatty liver by 37.9, 49.8, 53.6 and 20.2%, 37.2, 43.7%, respectively.ConclusionsTaken together, the results indicate that the dietary fiber pectin can mitigate some adverse consequences of overnutrition even in the presence of high-fat.

show abstract

Section: Discussionmentioning

confidence: 99%

Switching from a high-fat cellulose diet to a high-fat pectin diet reverses certain obesity-related morbidities

et al. 2018

View full text Add to dashboard Cite

show abstract

“…The increase in SDH-OD (without an increase in IMCL) after 8 weeks of a HFD was somewhat reduced after 16 weeks in the diaphragm. Such a decrease may be due to lower physical activity levels in response to a HFD (Moretto et al, 2017) that would particularly reduce the activity of the respiratory muscles. It may be that lower physical activity levels in old than in young mice (Ingram, 2000;Tallis et al, 2017a) may also underlie the absence of an increase in oxidative capacity in the muscles from old mice.…”

Section: Oxidative Capacitymentioning

confidence: 99%

The impact of a high-fat diet in mice is dependent on duration and age, and differs between muscles

Messa

Piasecki

Hurst

et al. 2020

Journal of Experimental Biology

View full text Add to dashboard Cite

Prolonged high-fat diets (HFDs) can cause intramyocellular lipid (IMCL) accumulation that may negatively affect muscle function. We investigated the duration of a HFD required to instigate these changes, and whether the effects are muscle specific and aggravated in older age. Muscle morphology was determined in the soleus, extensor digitorum longus (EDL) and diaphragm muscles of female CD-1 mice from 5 groups: young fed a HFD for 8 weeks (YS-HFD, n=16), young fed a HFD for 16 weeks (YL-HFD, n=28) and young control (Y-Con, n=28). The young animals were 20 weeks old at the end of the experiment. Old (70 weeks) female CD-1 mice received either a normal diet (O-Con, n=30) or a HFD for 9 weeks (OS-HFD, n=30). Body mass, body mass index and intramyocellular lipid (IMCL) content increased in OS-HFD (P≤0.003). In the young mice, this increase was seen in YL-HFD and not YS-HFD (P≤0.006). The soleus and diaphragm fibre cross-sectional area (FCSA) in YL-HFD was larger than that in Y-Con (P≤0.004) while OS-HFD had a larger soleus FCSA compared with that of O-Con after only 9 weeks on a HFD (P<0.001). The FCSA of the EDL muscle did not differ significantly between groups. The oxidative capacity of fibres increased in young mice only, irrespective of HFD duration (P<0.001). High-fat diet-induced morphological changes occurred earlier in the old animals than in the young, and adaptations to HFD were muscle specific, with the EDL being least responsive.

show abstract

“…For example, recently, work in Balb/c mice fed cafeteria diet showed that obesity-resistant mice increase their SPA (locomotor activity) in response to CAF diet, yet there were no differences in their SPA prior to CAF diet feeding [54]. In C57 mice, HFD feeding decreased SPA (locomotor activity) and NEAT [55], highlighting the bidirectional nature of the relationship between SPA and NEAT. Together, these data support the concept that SPA and NEAT contribute to obesity resistance, but there is extensive individual variation in the magnitude of effect, and the mechanisms by which SPA protects against obesity (e.g.…”

Section: Animal Models Of Spa and Obesitymentioning

confidence: 99%

Spontaneous Physical Activity Defends Against Obesity

et al. 2017

View full text Add to dashboard Cite

Spontaneous physical activity (SPA) is physical activity not motivated by a rewarding goal, such as that associated with food-seeking or wheel running behavior. SPA is often thought of as only “fidgeting”, but that is a mischaracterization, since fidgety behavior can be linked to stereotypies in neurodegenerative disease and other movement disorders. Instead, SPA should be thought of as all physical activity behavior that emanates from an unconscious drive for movement. An example of this may be restless behavior, which can include fidgeting and gesticulating, frequent sit-to-stand movement, and more time spent standing and moving. All physical activity burns calories, and as such, SPA could be manipulated as a means to burn calories, defend against weight gain and reduce excess adiposity. In this review, we discuss human and animal literature on the use of SPA in reducing weight gain, the neuromodulators that could be targeted to this end, and future directions in this field.

show abstract

The effects of calorie-matched high-fat diet consumption on spontaneous physical activity and development of obesity

Cited by 24 publications

References 55 publications

Switching from a high-fat cellulose diet to a high-fat pectin diet reverses certain obesity-related morbidities

Switching from a high-fat cellulose diet to a high-fat pectin diet reverses certain obesity-related morbidities

The impact of a high-fat diet in mice is dependent on duration and age, and differs between muscles

Spontaneous Physical Activity Defends Against Obesity

Contact Info

Product

Resources

About