1995
DOI: 10.1038/bjc.1995.183
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The effects of carbogen and nicotinamide on intravascular oxyhaemoglobin saturations in SCCVII and KHT murine tumours

Abstract: SaryConsierable effort has been focused on devising methods for pulating tumour oxygenation and thereby improing tumour radiosensitivity. The combination of nicotnamid

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Cited by 13 publications
(2 citation statements)
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“…Carbogen (95% O 2 +5% CO 2 ) is used to reduce diffusion limited or chronic hypoxia, and nicotinamide is added to reduce acute hypoxia resulting from temporary vasculature shutdown [135][136][137][138][139][140]. The use of these agents simultaneously has indeed been shown to increase the radiation damaging effect in a variety of rodent tumour models [141][142][143][144][145].…”
Section: Arconmentioning
confidence: 99%
“…Carbogen (95% O 2 +5% CO 2 ) is used to reduce diffusion limited or chronic hypoxia, and nicotinamide is added to reduce acute hypoxia resulting from temporary vasculature shutdown [135][136][137][138][139][140]. The use of these agents simultaneously has indeed been shown to increase the radiation damaging effect in a variety of rodent tumour models [141][142][143][144][145].…”
Section: Arconmentioning
confidence: 99%
“…Carbogen (95% O 2 +5% CO 2 ) is used to reduce diffusion limited or chronic hypoxia, and nicotinamide is added to reduce acute hypoxia resulting from temporary vasculature shutdown [135][136][137][138][139][140]. The use of these agents simultaneously has indeed been shown to increase the radiation damaging effect in a variety of rodent tumor models [141][142][143][144][145].…”
Section: Arconmentioning
confidence: 99%