The effects of celery leaf (<i>apium graveolens L</i>.) treatment on blood glucose and insulin levels in elderly pre-diabetics

Yusni, Yusni; Zufry, Hendra; Meutia, Firdalena; Sucipto, Krishna Wardhana

doi:10.15537/smj.2018.2.21238

Cited by 35 publications

(31 citation statements)

References 22 publications

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“…The treatment consisted of celery leaf extract capsules at the dose of 250 mg, three times daily for 12 days. Effectively, celery reduced blood glucose levels; however, there was not any correlation between blood glucose concentrations and plasma insulin levels in elderly prediabetic subjects (Yusni, Zufry, Meutia, & Sucipto, 2018). The data of beneficial effects of celery and its relevant components in some clinical studies are mentioned in Table 5.…”

Section: -16mentioning

confidence: 99%

Beneficial effects of celery (Apium graveolens) on metabolic syndrome: A review of the existing evidences

Hedayati

Naeini

Mohammadinejad

et al. 2019

Phytotherapy Research

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The metabolic syndrome (MetS) is a cluster of multiple conditions that includes hypertension, dyslipidemia, abdominal obesity, and hyperglycemia disorders. Most studies revealed that the MetS is accompanied with an increased risk for cardiovascular disease, Type 2 diabetes mellitus, and insulin resistance. It can be said that, in treating or preventing the MetS and its components, lifestyle adjustment and weight loss have a vital role. According to various studies, among natural compounds, celery (Apium graveolens) is one of the most important sources of phytochemicals such as phenolic acids, flavones, flavonols, and antioxidants such as vitamin C, beta‐carotene (Provitamin A), and manganese. These antioxidants have a role in decreasing the oxidative damage. The phytochemicals in celery decrease the activity of proinflammatory cytokines and prevent inflammation. Also, flavonoids in celery suppress cardiovascular inflammation. Oxidative stress and inflammation in the blood stream are the main risk factors in increasing cardiovascular disease, especially atherosclerosis. Celery phthalides leads to expanding of smooth muscle in the blood vessels and lower blood pressure. As a result, the most active ingredients in celery (A. graveolens (have shown hypolipidemic, antidiabetic, and hypotensive properties. In this review, we summarized the mechanisms underlying the protective effects of celery components on insulin action, glucose, lipid metabolism, and blood pressure.

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Section: -16mentioning

confidence: 99%

Beneficial effects of celery (Apium graveolens) on metabolic syndrome: A review of the existing evidences

Hedayati

Naeini

Mohammadinejad

et al. 2019

Phytotherapy Research

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“…Celery can provide health benefits owing to its phenolic acids and flavonoids contents. It has been demonstrated to have antioxidant activity (Popovic, Kaurinovic, Trivic, Mimica‐Dukic, & Bursac, 2006), liver protective effects (Abd El‐Mageed, 2011), and antidiabetic effects (Yusni, Zufry, Meutia, & Sucipto, 2018). However, the anti‐atopic dermatitis effects of celery are yet to be known.…”

Section: Introductionmentioning

confidence: 99%

Anti‐atopic dermatitis effects of hydrolyzed celery extract in mice

Nchang

Cho

Shin³

et al. 2020

J Food Biochem

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This study investigated the ameliorative effects of acid hydrolyzed celery extract (HCE) and celery extract (CE) in an atopic dermatitis (AD) mice model. The results of the study showed that HCE, more than CE improved AD‐like skin lesions caused by fluoro‐2,4‐dinitrobenzene and house dust mite antigen administration. Further analysis also showed the dominance of HCE than CE in preventing mast cell infiltration in the dermis; inhibiting the IL‐31 expression in mice skin and reducing the immunoglobulin‐E, IL‐4, IL‐5, TNF‐α, IFN‐γ, IL‐31, and TSLP in serum of mice. Using in vitro studies in a murine macrophage cell line, we showed that apigetrin, luteolin, and apigenin present in both extracts could be accountable for the observed effects as these three compounds and not apiin prevented the nitric oxide production in the murine macrophage. Based on this study, we suggest that hydrolyzing celery extracts can improve the therapeutic efficacy of celery extracts for management of AD. Practical applications Apigenin, apigetrin, and luteolin are known biologically active compounds present in celery. Acid hydrolysis could increase the biologically active compounds in natural products. The research investigated the effects of acid HCE in a mice model of atopic dermatitis. The data obtained from this study sheds light on the use of hydrolysis methods to improve the biological activities of plant extracts used in nutraceutical industries.

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“…This indicates that the higher the celery dose, the higher the expression of GLUT 4. Study conducted by Yusni et al, 2018, show that celery extract containing Quercetin which plays an important role in decreasing blood sugar on diabetic mice induced by Alloxan. Quercetin was identified not only to play role in the translocation of GLUT-4 mRNA into adipose cell membranes and skeletal cells but also could upregulate GLUT-4.…”

Section: Effect Of Celery Extract On Glut-4 Expression In Rat Skeletamentioning

confidence: 99%

Effect of Celery Extract on Fructose Induced Insulin Resistance Rattus norvegicus

Sukarno¹,

Mustika²,

Rejeki³

2020

FMI

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Diabetes mellitus (DM) is one of the global health problems and in the top 4th ranks as the main cause of death in developing countries (IDF, 2015). The pathogenesis of type II DM involves abnormalities in insulin secretion and activity that leads to insulin resistance. This research aims to study the efficacy of celery (Apium graveolens) as a prevention of insulin resistance. In this study, the samples were 45 Wistar rats (Rattus norvegicus), male sex, aged 4-6 weeks, weight 150-175 grams, and had normal fasting blood glucose levels by tested before treatment. The experimental animals were divided into 5 groups, K1 was negative control group (insulin resistance by given 20% fructose 1,86 g/kg BW PO qDay); K2 was positive control group (those given 20% fructose 1,86 g/kg BW PO qDay and standard insulin resistance therapy metformin 500 mg/kg BW PO qDay); the K3 treatment group was given 20% fructose 1,86 g/kg BW PO qDay and celery extract 200 mg/kg BW PO qDay; the K4 treatment group was given fructose 20% 1,86 mg/kg BW PO qDay and celery extract 400 mg/kg BW PO qDay; and the K5 treatment group was given fructose 20% 1,86 mg/kg BW PO qDay and celery extract 600 mg/kg BW PO qDay. The treatment had been given every day for 60 days. Fasting blood glucose levels were measured using a Glucometer. Fasting blood insulin levels were measured using ELISA, HOMA-IR was calculated using a standardized formula, and GLUT4 protein expression was measured using immunohistochemistry. It the end of the intervention, there was a significant decreased in fasting blood glucose (FBG) in K4 group compared with K1 (p <0.05), insulin resistance in K1 was characterized by a higher HOMA-IR value compared to the therapy group, especially K4 and K5 (p <0.05). There was an increase in GLUT-4 expression on K4 and K5 compared with K1 (p<0.05). It can be concluded that celery extract has antihyperglycemia effect and furthermore it can prevent insulin resistance condition.

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The effects of celery leaf (apium graveolens L.) treatment on blood glucose and insulin levels in elderly pre-diabetics

Cited by 35 publications

References 22 publications

Beneficial effects of celery (Apium graveolens) on metabolic syndrome: A review of the existing evidences

Beneficial effects of celery (Apium graveolens) on metabolic syndrome: A review of the existing evidences

Anti‐atopic dermatitis effects of hydrolyzed celery extract in mice

Effect of Celery Extract on Fructose Induced Insulin Resistance Rattus norvegicus

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