The Effects of Certain Vegetable and Animal Fats on the Plasma Lipids of Humans

The anti-coronary club. A dietary approach to the prevention of coronary heart disease--a seven-year report.

“…This observed increase in depot fat linoleic acid therefore indicates that adherence to the study diet has been satisfactory. Experimental demonstration of the serum cholesterol-lowering effect of diets relatively rich in polyunsaturated fats, [15][16][17][18] supports the conviction that our study diet is responsible for the long-term depression of serum cholesterol observed in Anti-Coronary Club subjects.…”

“…In previous reports the composition of the experimental diet (or "Prudent Diet") has been described, and data presented which suggested that adherence to this diet can significantly lower the level of serum cholesterol of both normal and overweight coronary and noncoronary subjects. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] Concurrent with the maintenance of lowered level of serum cholesterol over a five-year period, a progressive increase in the per cent composition of linoleic acid in the depot fat of AntiCoronary Club subjects has been observed.14 According to present knowledge, linoleic acid, an essential unsaturated fatty acid, can only be derived from dietary sources. This observed increase in depot fat linoleic acid therefore indicates that adherence to the study diet has been satisfactory.…”

Effects of Dietary Phytosterols on Liver Lipids and Lipid Metabolism Enzymes

“…First, phytosterols play an inhibitory role in cholesterol digestive absorption in rats [9], in rabbits [22], in chicken [23. 24] and in man [25][26][27], Second, phytosterols act on rate-limiting en zymes of sterols metabolism. H M G -CoA -reductase and cholesterol-7-a-hydroxylase.…”

II. Role of Unsaturated Fat in Adult Nutrition

“…[25][26][27] The first feeding trial was designed to assess the effect of several types of animal fat on plasma cholesterol levels. The basal diet was comprised of skim milk powder, a type of fat, a vitamin supplement, and celluflour and provided 16.9, 58.5, and 24.6 per cent of calories as protein, fat, and carbohydrate, respectively.…”