The effects of chlorhexidine and mechanical methods of plaque control on the recurrence of gingival hyperplasia in young patients taking phenytoin

O'Neil, T. C. A.; Figures, K H

doi:10.1038/sj.bdj.4804760

Cited by 32 publications

(17 citation statements)

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“…O'Neil and Figures [39] have shown that regular use of chlorhexidine mouth rinse helps reduce chances of recurrence after gingival surgery. We could not find out if any other mouthwash has been used for prophylactic or therapeutic purpose in such cases.…”

Section: Mouth Rinsesmentioning

confidence: 97%

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Prevalence and clinical aspects of drug-induced gingival enlargement

Ahmed¹,

Bey²,

Hashmi³

et al. 2009

Biomed Res

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Drug-induced gingival enlargement is an iatrogenic condition which is usually not preventable. Certain factors like thorough tooth brushing, proper oral hygiene measures, regular dental flossing and professional care of oral cavity are helpful. Surgical excision of the gingival overgrowth is a treatment of choice but non-surgical methods should be adopted first. More research is needed to investigate measures that can prevent or reduce gingival overgrowth or prevent recurrence. A thorough review of literature reveals that inadequate data exist pertaining to prevalence and treatment options available for iatrogenic gingival hyperplasia. Studies with large number of samples, with statistical analysis, are required to make the data more scientific. Preventive measures have limited value and require regular assessment of patients. Hyperplasia does occur after surgical intervention but percentage of recurrence is not available. Hyperplasia can be managed to a certain extent by withdrawing or changing the medication. However, surgical intervention remains the mainstay of treatment. This paper reviews various aspects of prevalence, pathogenesis and treatment options available to manage drug-induced gingival hyperplasia.

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Section: Mouth Rinsesmentioning

confidence: 97%

“…The concomitant use of calcium channel blocker increases both the severity and prevalence of drug-induced gingival hyperplasia [38]. Thus the change in medication from cyclosporine to tacrolimus neither reduces the severity nor leads to complete resolution of overgrowth [39].…”

Section: Drug Substitution/withdrawalmentioning

confidence: 99%

Prevalence and clinical aspects of drug-induced gingival enlargement

Ahmed¹,

Bey²,

Hashmi³

et al. 2009

Biomed Res

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“…Some of the known risk factors include: presence of gingival inflammation (gingivitis due to poor oral hygiene); presence of dental plaque; and the dose and duration of drug therapy. [26][27][28] Gingival enlargement may cause significant morbidity because it poses an oral hygiene and dental plaque control problem; the tooth discomfort may affect mastication; it may alter tooth eruption; it may interfere with speech; and it may cause aesthetic concerns. 29 The term ''gingival hyperplasia'' is inappropriate because enlargement does not result from an increase in the number of cells but rather an increase in extracellular tissue volume with an inflammatory infiltrate of predominantly B lymphocytes.…”

Section: Discussionmentioning

confidence: 99%

Verapamil induced gingival enlargement in cluster headache

Matharu

Vliet²,

Ferrari³

et al. 2005

Journal of Neurology, Neurosurgery & Psychiatry

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“…Some studies have found significant correlations between the incidence and/or severity of GO and the amount of accumulated dental plaque and calculus [67, 68]. Other studies have shown that satisfactory oral hygiene is able to reduce the overgrowth, but not to completely prevent it [69, 70].…”

Section: Bacterial Biofilm and Pgo Developmentmentioning

confidence: 99%

Phenytoin-Induced Gingival Overgrowth: A Review of the Molecular, Immune, and Inflammatory Features

et al. 2011

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Gingival overgrowth (GO) is a side effect associated with some distinct classes of drugs, such as anticonvulsants, immunosuppressant, and calcium channel blockers. GO is characterized by the accumulation of extracellular matrix in gingival connective tissues, particularly collagenous components, with varying degrees of inflammation. One of the main drugs associated with GO is the antiepileptic phenytoin, which affects gingival tissues by altering extracellular matrix metabolism. Nevertheless, the pathogenesis of such drug-induced GO remains fulfilled by some contradictory findings. This paper aims to present the most relevant studies regarding the molecular, immune, and inflammatory aspects of phenytoin-induced gingival overgrowth.

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The effects of chlorhexidine and mechanical methods of plaque control on the recurrence of gingival hyperplasia in young patients taking phenytoin

Cited by 32 publications

References 0 publications

Prevalence and clinical aspects of drug-induced gingival enlargement

Prevalence and clinical aspects of drug-induced gingival enlargement

Verapamil induced gingival enlargement in cluster headache

Phenytoin-Induced Gingival Overgrowth: A Review of the Molecular, Immune, and Inflammatory Features

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