The Effects of Chronic Lead Exposure on Testicular Development of Japanese Quail (Coturnix japonica): Histopathological Damages, Oxidative Stress, Steroidogenesis Disturbance, and Hypothalamus-Pituitary-Testis Axis Disruption

Zheng, Ying; Jing, Lingyang; Fei, Yifan; Zhao, Hongfeng

doi:10.1007/s12011-022-03436-8

Cited by 14 publications

(4 citation statements)

References 70 publications

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Section: Discussionmentioning

confidence: 99%

“…This axis involves GnRH released by the hypothalamus, which then binds to its receptor in the pituitary gland and stimulates the secretion of LH and FSH. LH stimulates the Leydig cells to synthesize, secrete, and release T. 34 FSH protects T from degradation and maintains high T levels in testes for spermatogenesis. 35 Our findings indicated that AFB 1 decreased the level of LH, and FSH, indicating AFB 1 disrupted the LH and FSH secretion to suppress the T biosynthesis.…”

Section: Discussionmentioning

confidence: 99%

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Aflatoxin B1-Induced Testosterone Biosynthesis Disorder via the ROS/AMPK Signaling Pathway in Male Mice

Huang,

Zhang,

Miao

et al. 2024

J. Agric. Food Chem.

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The worldwide prevalence of Aflatoxin B1 (AFB 1 ), which contaminates feedstock and food, is on the rise. AFB 1 inhibits testosterone (T) biosynthesis, but the mechanism is not yet clear. By establishing in vivo and in vitro models, this study found the number of Leydig cells (LCs), T content, and the expression of T biosynthesis key enzymes were suppressed after AFB 1 treatment. AFB 1 exposure also increased reactive oxygen species (ROS) and promoted mitochondrial injury and mitochondrial pathway apoptosis. Moreover, the AMPK signaling pathway was activated, and using an AMPK inhibitor relieved apoptosis and the suppressed T biosynthesis key enzymes of LCs caused by AFB 1 through regulating downstream p53 and Nur77. Additionally, adding ROS intervention could inhibit AMPK activation and alleviate the decreased T content caused by AFB 1 . In summary, AFB 1 promotes the apoptosis of LCs and inhibits T biosynthesis key enzyme expression via activating the ROS/AMPK signaling pathway, which eventually leads to T synthesis disorder.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Aflatoxin B1-Induced Testosterone Biosynthesis Disorder via the ROS/AMPK Signaling Pathway in Male Mice

Huang,

Zhang,

Miao

et al. 2024

J. Agric. Food Chem.

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“…The blood–testis barrier, certain seminiferous tubules, and the basement membrane have been found to undergo damage in poultry ( 155 ). As a result of Pb deposition, spermatogenic cells have been found to be organized erratically and to produce more spermatogonium, and the spermatogenic tubes are distorted ( 156 ).…”

Section: Sources Of Heavy Metal Transmission and Their Impact On Poultrymentioning

confidence: 99%

Heavy metal toxicity in poultry: a comprehensive review

Aljohani

2023

Front. Vet. Sci.

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Arsenic (As), lead (Pb), cadmium (Cd), and mercury (Hg) have been recognized as most toxic heavy metals that are continuously released into the environment, both from natural sources and from anthropogenic production of fertilizers, industrial activities, and waste disposal. Therefore, As, Cd, Hg, and Pb are found in increasing concentrations in bodies of water, fodder, feed, and in the tissues of livestock, including poultry, in the surroundings of industrial areas, leading to metabolic, structural, and functional abnormalities in various organs in all animals. In poultry, bioaccumulation of As, Pb, Cd, and Hg occurs in many organs (mainly in the kidneys, liver, reproductive organs, and lungs) as a result of continuous exposure to heavy metals. Consumption of Cd lowers the efficiency of feed conversion, egg production, and growth in poultry. Chronic exposure to As, Pb, Cd, and Hg at low doses can change the microscopic structure of tissues (mainly in the brain, liver, kidneys, and reproductive organs) as a result of the increased content of these heavy metals in these tissues. Histopathological changes occurring in the kidneys, liver, and reproductive organs are reflected in their negative impact on enzyme activity and serum biochemical parameters. Metal toxicity is determined by route of exposure, length of exposure, and absorbed dosage, whether chronic and acute. This review presents a discussion of bioaccumulation of As, Cd, Pb, and Hg in poultry and the associated histopathological changes and toxic concentrations in different tissues.

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“…(Jakop et al, 2019; Ri et al, 2022). Taking into account the role of redox imbalance in disrupting the hypothalamic–pituitary–gonadal dynamic, steroidogenic‐related gene expression, and semen characters (Hafez et al, 2023; Zheng et al, 2023), natural products having redox stabilising potentials are worthwhile in enhancing the masculine reproductive capacity. From this perspective, PUFAs support the antioxidant shield by activating the redox‐sensitive transcription factors and synthesis of cytoprotective elements against the electrophilic harmful agents (Bergamo et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Role of Eruca sativa L. seeds in boosting the reproductive performance of male Japanese quails (Coturnix c. japonica)

Waly,

Abdelfattah,

Abou Khalil

et al. 2023

Animal Physiology Nutrition

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Herein we attempt to shed light on the potential improving effect of Eruca sativa seeds (ESS) on the reproductive aspects of male Japanese quails. To accomplish this objective, two groups of quails were supplemented with ESS powder at doses of 5 and 10 g/kg feed from 7 days to 140 days of age, in addition to the control group, which did not receive treatment. Forty males were reared singly in cages to evaluate sperm characters and 32 males were raised with 64 females to evaluate fertility and sperm penetrability. Sixty‐six phytochemical compounds were found according to gas chromatography–mass spectrometry analysis of ESS. The most plentiful ones are 13‐docosenoic acid methyl ester, 9‐octadecenoic acid methyl ester, and linoleic acid methyl ester. Both 5 g/kg and 10 g/kg doses of ESS showed similar effectiveness in enhancing various reproductive parameters, including gonadal index, sperm characteristics, fertility, libido, and cloacal gland attributes. However, some aspects like sperm concentration and testosterone levels exhibited a dose‐dependent response. There is no significant change in mortality rate of supplemented groups compared to the control one. ESS also caused a reduction in feed intake and an enhancement in feed conversion ratio without affecting final body weight and body weight gain. This suggests potential nutritional benefits beyond reproductive health. The low‐dose‐fed group showed a significant reduction in total cholesterol and malondialdehyde compared to the high‐dose‐fed and unfed groups. The higher dose notably increased total antioxidant capacity compared to the lower dose and control group. Despite the positive effects on male reproductive parameters, there wasn't a significant impact on hatchability percentage, indicating that while male fertility improved, it might not have directly affected the viability of the eggs. Overall, the study suggests that ESS could be a safe and promising addition to the diet of male Japanese quails to enhance their reproductive capabilities without adverse effects. The findings could have implications for poultry farming by potentially improving breeding efficiency and health outcomes in quails.

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The Effects of Chronic Lead Exposure on Testicular Development of Japanese Quail (Coturnix japonica): Histopathological Damages, Oxidative Stress, Steroidogenesis Disturbance, and Hypothalamus-Pituitary-Testis Axis Disruption

Cited by 14 publications

References 70 publications

Aflatoxin B1-Induced Testosterone Biosynthesis Disorder via the ROS/AMPK Signaling Pathway in Male Mice

Aflatoxin B1-Induced Testosterone Biosynthesis Disorder via the ROS/AMPK Signaling Pathway in Male Mice

Heavy metal toxicity in poultry: a comprehensive review

Role of Eruca sativa L. seeds in boosting the reproductive performance of male Japanese quails (Coturnix c. japonica)

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