The effects of chronic social defeat stress on mouse self-grooming behavior and its patterning

Denmark, Ashley; Tien, David; Wong, Keith; Chung, Amanda; Cachat, Jonathan; Goodspeed, Jason; Grimes, Chelsea; Elegante, Marco; Suciu, Christopher; Elkhayat, Salem; Bartels, Brett; Jackson, Andrew; Rosenberg, Michael; Chung, Kyung Min; Badani, Hussain; Kadri, Ferdous; Roy, Sudipta; Tan, Julia; Gaikwad, Siddharth; Stewart, Adam; Zapolsky, Ivan; Gilder, Thomas; Kalueff, Allan V.

doi:10.1016/j.bbr.2009.12.041

Cited by 81 publications

(56 citation statements)

References 65 publications

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“…This general social fear is similar to the general social avoidance induced by chronic social defeat (Avgustinovich et al, 2005;Berton et al, 2006), where several dominant males are consecutively used to defeat a subordinate animal (Miczek, 1979;Rodgers and Randall 1986;Kabbaj et al, 2001). However, chronic social defeat also increased general anxiety (Keeney and Hogg, 1999;Avgustinovich et al, 2005;Berton et al, 2006;Denmark et al, 2010), decreased locomotor activity (Koolhaas et al, 1997;Rygula et al, 2005), and induced a depressive-like phenotype (Avgustinovich et al, 2005;Rygula et al, 2005;Berton et al, 2006;Hollis et al, 2010). Correspondingly, these behavioral changes might account for the decreased social investigation observed.…”

Section: Discussionmentioning

confidence: 98%

“…Foot-shock exposure is used as exposure to a single (Short and Maier, 1993;Siegmund and Wotjak, 2007) or to repeated foot shocks (Haller and Bakos, 2002;Louvart et al, 2005;Mikics et al, 2008a). Although social defeat and foot-shock exposure decrease social investigation, they also lead to behavioral alterations including increased general anxiety, depression, and impaired locomotion that might account for the observed social deficit (Denmark et al, 2010;Hollis et al, 2010). Furthermore, in the case of acute social defeat, the induced social avoidance is generally directed toward the con-specific that performed the defeat (Lai et al, 2005;Lukas et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…Social anxiety/avoidance is presently induced using a number of paradigms, including the social defeat paradigm-used both acutely and chronically (for reviews see Huhman, 2006;Yan et al, 2010), and foot-shock exposure (Haller and Bakos, 2002;Louvart et al, 2005;Mikics et al, 2008a). However, these paradigms are rather unspecific with respect to the behavioral alterations they induce, as increased general anxiety, depression, and impaired locomotion were found to accompany the social avoidance (Denmark et al, 2010;Hollis et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Social Fear Conditioning: A Novel and Specific Animal Model to Study Social Anxiety Disorder

Toth

Neumann

Slattery

2012

Neuropsychopharmacol

125

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Social anxiety disorder (SAD) is a major health concern with high lifetime prevalence. The current medication is rather unspecific and, despite considerable efforts, its efficacy is still unsatisfactory. However, there are no appropriate and specific animal models available to study the underlying etiology of the disorder. Therefore, we aimed to establish a model of specific social fear in mice and use this social fear conditioning (SFC) model to assess the therapeutic efficacy of the benzodiazepine diazepam and of the antidepressant paroxetine; treatments currently used for SAD patients. We show that by administering electric foot shocks (2-5, 1 s, 0.7 mA) during the investigation of a con-specific, the investigation of unfamiliar con-specifics was reduced for both the short-and long-term, indicating lasting social fear. The induced fear was specific to social stimuli and did not lead to other behavioral alterations, such as fear of novelty, general anxiety, depression, and impaired locomotion. We show that social fear was dose-dependently reversed by acute diazepam, at doses that were not anxiolytic in a non-social context, such as the elevated plus maze. Finally, we show that chronic paroxetine treatment reversed social fear. All in all, we demonstrated robust social fear after exposure to SFC in mice, which was reversed with both acute benzodiazepine and chronic antidepressant treatment. We propose the SFC model as an appropriate animal model to identify the underlying etiology of SAD and possible novel treatment approaches.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Social Fear Conditioning: A Novel and Specific Animal Model to Study Social Anxiety Disorder

Toth

Neumann

Slattery

2012

Neuropsychopharmacol

125

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“…This allowed us, for the first time, to assess effects of domestication on behavioural and endocrine stress responses in chickens. In particular, we focused on the recovery process and the return to normal levels of both behaviour and concentrations of the steroids, using a similar approach as in earlier research on stress recovery [33][34][35][36][37][38][39][40].…”

Section: Introductionmentioning

confidence: 99%

Domestication effects on behavioural and hormonal responses to acute stress in chickens

Ericsson

Fallahsharoudi

Bergquist

et al. 2014

Physiology & Behavior

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Comparative studies have shown that alterations in physiology, morphology and behaviour have arisen due to the domestication. A driving factor behind many of the changes could be a shift in stress responses, with modified endocrine and behavioural profiles. In the present study we compared two breeds of chicken (Gallus gallus), the domestic White Leghorn (WL) egg laying breed and its ancestor, the Red Junglefowl (RJF). Birds were exposed to an acute stress event, invoked by three or ten minutes of physical restraint. They were then continuously monitored for the effects on a wide range of behaviours during a 60 min recovery phase. Blood samples were collected from the chicken at baseline, and after 10 and 60 min following a similar restraint stress, and the samples were analyzed for nine endogenous steroids of the HPA and HPG axis. Concentration of the steroids was determined using validated liquid chromatography tandem mass spectrometry methods. In RJF, an immediate behavioural response was observed after release from restraint in several behaviours, with a relatively fast return to baseline within one hour. In WL, some behaviours were affected for a longer period of time, and others not at all. Concentrations of corticosterone increased more in RJF, but returned faster to baseline compared to WL. A range of baseline levels for HPG-related steroids differed between the breeds, and they were generally more affected by the stress in WL than in RJF. In conclusion, RJF reacted stronger both behaviourally and physiologically to the restraint stress, but also recovered faster. This would appear to be adaptive under natural conditions, whereas the stress recovery of domesticated birds has been altered by domestication and breeding for increased reproductive output.

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“…These results in maternal rats are supported by studies in virgin females, where chronic social instability (varying isolation and crowding) increases hypothalamic-pituitaryadrenal axis activity 11,21, alters body temperature regulation, reduces sucrose and food intake, and has been proposed as an animal model for female depression 11 . Self grooming, a measure of anxiety 22,23 is also sensitive to social stress manipulations 24,25 .…”

Section: Introductionmentioning

confidence: 99%

Using Chronic Social Stress to Model Postpartum Depression in Lactating Rodents

Carini

Murgatroyd

Nephew

2013

JoVE

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Exposure to chronic stress is a reliable predictor of depressive disorders, and social stress is a common ethologically relevant stressor in both animals and humans. However, many animal models of depression were developed in males and are not applicable or effective in studies of postpartum females. Recent studies have reported significant effects of chronic social stress during lactation, an ethologically relevant and effective stressor, on maternal behavior, growth, and behavioral neuroendocrinology. This manuscript will describe this chronic social stress paradigm using repeated exposure of a lactating dam to a novel male intruder, and the assessment of the behavioral, physiological, and neuroendocrine effects of this model. Chronic social stress (CSS) is a valuable model for studying the effects of stress on the behavior and physiology of the dam as well as her offspring and future generations. The exposure of pups to CSS can also be used as an early life stress that has long term effects on behavior, physiology, and neuroendocrinology.

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The effects of chronic social defeat stress on mouse self-grooming behavior and its patterning

Cited by 81 publications

References 65 publications

Social Fear Conditioning: A Novel and Specific Animal Model to Study Social Anxiety Disorder

Social Fear Conditioning: A Novel and Specific Animal Model to Study Social Anxiety Disorder

Domestication effects on behavioural and hormonal responses to acute stress in chickens

Using Chronic Social Stress to Model Postpartum Depression in Lactating Rodents

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