The Effects of Combined toxicity of Silver and Silicon Nanoparticles on Hematological and Biochemical Parameters in Male Albino Mice

Abstract

In this study, the potential combined effects of silver (AgNPs) and silicon dioxide nanoparticles (SiO2NPs) on male albino mice which were exposed intraperitoneally to the 50 mg/kg and 100 mg/kg and mixed concentrations of nanoparticles (NPs) for periods of 2 and 4 weeks, were evaluated. The evaluation was performed by examining the haematological and biochemical parameters, in addition to the bioaccumulation of NPs in the liver and kidney. The results showed that the platelets count significantly increased in all exposed groups, while red blood cell count (RBCs) decreased in most exposed groups. White blood cells (WBCs) and haemoglobin (Hb) showed different levels in the exposed groups. Serum aspartate aminotransferase (AST) and serum alanine aminotransferase (ALT) levels also showed a significant increase in the exposed groups, except in the groups exposed to 100 mg/kg of NPs for 2 weeks. Whereas blood urea nitrogen) BUN) serum level showed a significant decrease in all exposed groups. However, the alkaline phosphatase (ALP), uric acid (UA) and creatinine (CR) levels did not show any significant alternations in the exposed groups. Significant increase was also noted in thyroid-stimulating hormone (TSH) levels among the exposed groups. An accumulation of AgNPs and SiO2NPs was observed both in livers and kidneys in the exposed groups. The results showed that SiO2NPs have a synergistic effect on AgNPs accumulation in the groups exposed to mixed nanoparticles.

In Vitro Novel Study the Effect of Scopoletin Compound and Silver Nanoparticles of Fenugreek Extract on Focal Adhesion Kinase Enzyme as Anti-Metastatic in Serum of Iraqi Patients of Stage ιι and Stage ιιι with Pancreatic Cancer

“…Plant extracts operate as reducers, capping agents, and stabilizers. A multidisciplinary scientific discipline called nanotechnology seeks to develop atomic, molecular, and supramolecular materials with improved properties (20,21,22) . Nanomaterials are employed in the detection of glucose, DNA and RNA, heavy detection, disease diagnosis, disease control, and microelectronics (23) .…”