The effects of continuous wave and pulsed ultrasound on rat thymocytes in vitro

Dooley, David A.; Child, Sally Z.; Carstensen, Edwin L.; Miller, Morton W.

doi:10.1016/0301-5629(83)90091-1

Cited by 18 publications

(10 citation statements)

References 9 publications

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“…It was reported that macrophages contain a stretch‐sensitive potassium channel, the activity of which was modified by mechanical stress (27,28) . Furthermore, it was reported that high‐energy ultrasound modulated the activity of thymocytes (29) Blood flow and neovascularization.…”

Section: Discussionmentioning

confidence: 99%

Low-Intensity Pulsed Ultrasound Accelerates Rat Femoral Fracture Healing by Acting on the Various Cellular Reactions in the Fracture Callus

Azuma

Ito

Harada

et al. 2001

Journal of Bone and Mineral Research

334

213

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Low-intensity pulsed ultrasound (LIPUS) has been shown to accelerate fracture healing in both animal models and clinical trials, but the mechanism of action remains unclear. In fracture healing, various consecutive cellular reactions occurred until repair. We investigated whether the advanced effects of LIPUS depended on the duration and timing of LIPUS treatment in a rat closed femoral fracture model to determine the target of LIPUS in the healing process. Sixty-nine Long-Evans male rats that have bilateral closed femoral fractures were used. The right femur was exposed to LIPUS (30 mW/cm 2 spatial and temporal average [SATA], for 20 minutes/day), and the left femur was used as a control. Rats were divided into four groups according to timing and duration of treatment (Ph-1, days 1-8; Ph-2, days 9 -16; Ph-3, days 17-24; throughout [T], days 1-24 after the fracture). Animals were killed on day 25. After radiographs and microfocus X-ray computed tomography (CT) tomograms were taken, the hard callus area (HCA), bone mineral content (BMC) at the fracture site, and mechanical torsion properties were measured, and histological analysis was conducted. Interestingly, the maximum torque of the LIPUS-treated femur was significantly greater than that of the controls in all groups without any changes in HCA and BMC. The multiviewing of three-dimensional (3D) CT reconstructions and histology supported our findings that the partial LIPUS treatment time was able to accelerate healing, but longer treatment was more effective. These results suggest that LIPUS acts on some cellular reactions involved in each phase of the healing process such as inflammatory reaction, angiogenesis, chondrogenesis, intramembranous ossification, endochondral ossification, and bone remodeling. (J Bone Miner Res 2001;16:671-680)

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Section: Discussionmentioning

confidence: 99%

Low-Intensity Pulsed Ultrasound Accelerates Rat Femoral Fracture Healing by Acting on the Various Cellular Reactions in the Fracture Callus

Azuma

Ito

Harada

et al. 2001

Journal of Bone and Mineral Research

334

213

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“…Ultrasound technique, is a therapeutically and diagnostically well established technique for over a decade now (Lindner, 2004; Kaufmann et al, 2007). Ultrasound technique apart from its conventional applications is also used to stimulate cell membrane permeabilization and sonoporation to enhance the anti-cancer efficacy of chemotherapeutic agents and to transfer plasmid DNA in-vivo and in-vitro setting (Dooley et al, 1983; Fechheimer et al, 1987). A study by Shintani et al concluded that admission of oHSV-1 into the host Oral Squamous Cell Carcinoma (SCC) Cells was accelerated with the help of ultrasound technique.…”

Section: Advances In Oncolytic Herpes Simplex Viral Therapymentioning

confidence: 99%

Oncolytic Herpes Simplex Viral Therapy: A Stride toward Selective Targeting of Cancer Cells

2017

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Oncolytic viral therapy, which makes use of replication-competent lytic viruses, has emerged as a promising modality to treat malignancies. It has shown meaningful outcomes in both solid tumor and hematologic malignancies. Advancements during the last decade, mainly genetic engineering of oncolytic viruses have resulted in improved specificity and efficacy of oncolytic viruses in cancer therapeutics. Oncolytic viral therapy for treating cancer with herpes simplex virus-1 has been of particular interest owing to its range of benefits like: (a) large genome and power to infiltrate in the tumor, (b) easy access to manipulation with the flexibility to insert multiple transgenes, (c) infecting majority of the malignant cell types with quick replication in the infected cells and (d) as Anti-HSV agent to terminate HSV replication. This review provides an exhaustive list of oncolytic herpes simplex virus-1 along with their genetic alterations. It also encompasses the major developments in oncolytic herpes simplex-1 viral therapy and outlines the limitations and drawbacks of oncolytic herpes simplex viral therapy.

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“…Moreover, ultrasound as a means of stimulating cell membrane permeabilization offers advantages over other technologies, primarily as a result of its relatively non-invasive nature [16,17]. It enhances the antitumor effect of chemotherapeutic agents and the delivery of plasmid DNA in vitro and in vivo [18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Enhancing effect of ultrasound on boron concentrations in an oral squamous cell carcinoma cell line SAS for boron neutron capture therapy

Yamamoto

Masunaga

Kato

et al. 2015

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathol

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The effects of continuous wave and pulsed ultrasound on rat thymocytes in vitro

Cited by 18 publications

References 9 publications

Low-Intensity Pulsed Ultrasound Accelerates Rat Femoral Fracture Healing by Acting on the Various Cellular Reactions in the Fracture Callus

Low-Intensity Pulsed Ultrasound Accelerates Rat Femoral Fracture Healing by Acting on the Various Cellular Reactions in the Fracture Callus

Oncolytic Herpes Simplex Viral Therapy: A Stride toward Selective Targeting of Cancer Cells

Enhancing effect of ultrasound on boron concentrations in an oral squamous cell carcinoma cell line SAS for boron neutron capture therapy

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