The effects of cranberry juice consumption on antioxidant status and biomarkers relating to heart disease and cancer in healthy human volunteers

Duthie, Susan J.; Jenkinson, A. McE.; Crozier, Alan; Mullen, William; Pirie, Lynn P.; Kyle, James; Yap, L. S.; Christen, Peter; Duthie, Garry G.

doi:10.1007/s00394-005-0572-9

Cited by 278 publications

(260 citation statements)

References 62 publications

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“…42 Human intervention studies using berries (either fresh, as juice, or freeze-dried), or purified anthocyanin extracts have demonstrated significant improvements in antioxidant activities, including lowdensity lipoprotein oxidation and lipid peroxidation. 43,44 These benefits were recognized in healthy subjects as well as in those with existing metabolic risk factors. It has been suggested that underlying mechanisms of these beneficial effects include upregulation of endothelial NO synthase, decreased activities of carbohydrate-digestive enzymes, decreased oxidative stress, and inhibition of inflammatory gene expression.…”

Section: Discussionmentioning

confidence: 99%

Black Currant Anthocyanins Normalized Abnormal Levels of Serum Concentrations of Endothelin-1 in Patients with Glaucoma

Yoshida

Ohguro

2013

Journal of Ocular Pharmacology and Therapeutics

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Purpose: Our recent study, which involved a randomized, placebo-controlled, double-masked 24-month trial (Ophthalmologica 2012;228:26-35), revealed that oral administration of black currant anthocyanins (BCACs) slowed down the visual field deterioration and elevation of ocular blood flow of open-angle glaucoma (OAG). To elucidate the underlying mechanisms of these BCAC-induced effects, as possible factors affecting glaucomatous optic neuropathy, changes of serum endothelin-1 (ET-1), nitric oxide (NO), and antioxidative activities were examined in the present study. Methods: From among patients with OAG who participated in the randomized, placebo-controlled, doublemasked trial, serum specimens were obtained from BCAC-treated (n = 19) or placebo-treated (n = 19) patients at baseline and every 6 months. Healthy volunteers (n = 20) with age and gender matching the patients were used as a control. Serum ET-1 concentration, [NO 2 -] and [NO 2 -+ NO 3 -] levels, advanced oxidation protein products (AOPP), and antioxidant activities were measured by using commercially available kits. Results: At the trial baseline, serum ET-1 concentrations were significantly lower in patients with OAG (BCACs, 3.18 -1.06 pg/mL; placebo, 3.44 -0.84 pg/mL) than those in healthy volunteers (4.38 -1.03 pg/mL) (one-way analysis of variance and a Tukey's multiple comparison post hoc test, P < 0.05). Upon administration of BCACs, serum ET-1 concentrations increased to the levels of those in healthy volunteers during the 24-month period. In contrast, those of placebo-treated patients remained at lower levels (3.82 -1.14 pg/mL). While [NO 2 -] and [NO 2 -+ NO 3 -] levels, AOPP, and antioxidative activities of patients from both the BCACs and placebo groups showed comparable levels to those of healthy subjects at baseline, no significant changes were observed during the observational period in either the BCAC or placebo groups. Conclusions: Among the possible beneficial effects of BCACs toward visual field progression in patients with OAG, our present results suggest that BCACs caused normalization of serum ET-1 levels, and this may modulate ET-1-dependent regulation of the ocular blood hemodynamics.

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Section: Discussionmentioning

confidence: 99%

Black Currant Anthocyanins Normalized Abnormal Levels of Serum Concentrations of Endothelin-1 in Patients with Glaucoma

Yoshida

Ohguro

2013

Journal of Ocular Pharmacology and Therapeutics

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“…Colorectum, azoxymethane-treated rats [20] Colorectum, azoxymethane-treated rats [21] Colorectum, azoxymethane-treated rats [44] Colorectum, DMH-and PhIP-treated rats [18] Freeze-dried black raspberries Healthy volunteers [70] Healthy volunteers [71] Healthy volunteers [72] Healthy volunteers [73] Healthy …”

Section: Conflict Of Interest Disclosures: Nonementioning

confidence: 99%

Do anthocyanins and anthocyanidins, cancer chemopreventive pigments in the diet, merit development as potential drugs?

Thomasset

Teller

Cai

et al. 2009

Cancer Chemother Pharmacol

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Anthocyanins, plant pigments in fruits and berries, have been shown to delay cancer development in rodent models of carcinogenesis, especially those of the colorectal tract. Anthocyanins and anthocyanidins, their aglycons, especially cyanidin and delphinidin, have been subjected to extensive mechanistic studies. In cells in vitro, both glycosides and aglycons engage an array of anti-oncogenic mechanisms including anti-proliferation, induction of apoptosis and inhibition of activities of oncogenic transcription factors and protein tyrosine kinases. Anthocyanins and anthocyanidins exist as four isomers, interconversion between which depends on pH, temperature and access of light. Anthocyanidins are much more prone to avid chemical decomposition than the glycosides, and they only survive for minutes in the biophase. These pharmaceutical issues are very important determinants of the suitability of these flavonoids for potential development as cancer chemopreventive drugs, and they have hitherto not received adequate attention. In the light of their robust cancer chemopreventive efficacy in experimental models and their superior stability as compared to that of the aglycons, the anthocyanins seem much more suitable for further drug development than their anthocyanidin counterparts.

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“…There is some evidence from epidemiological studies that suggests a higher consumption of anthocyanin-rich foods is associated with a reduced risk for cardiovascular disease [8,9]. However, intervention studies do not always support these findings [10]. In the case of blood pressure, plausible mechanisms from experimental studies include their effects on vascular blood flow and flow-mediated dilation (FMD) [11,12].…”

Section: Introductionmentioning

confidence: 99%

Anthocyanin-rich plum juice reduces ambulatory blood pressure but not acute cognitive function in younger and older adults: a pilot crossover dose-timing study

et al. 2017

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The effects of cranberry juice consumption on antioxidant status and biomarkers relating to heart disease and cancer in healthy human volunteers

Cited by 278 publications

References 62 publications

Black Currant Anthocyanins Normalized Abnormal Levels of Serum Concentrations of Endothelin-1 in Patients with Glaucoma

Black Currant Anthocyanins Normalized Abnormal Levels of Serum Concentrations of Endothelin-1 in Patients with Glaucoma

Do anthocyanins and anthocyanidins, cancer chemopreventive pigments in the diet, merit development as potential drugs?

Anthocyanin-rich plum juice reduces ambulatory blood pressure but not acute cognitive function in younger and older adults: a pilot crossover dose-timing study

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