The effects of crocus sativus extract on serum lipid profile and liver enzymes in patients with non-alcoholic fatty liver disease: A randomized placebo-controlled study

Parsi, Abazar; Torkashvand, Mariya; Hajiani, Eskandar; Rahimlou, Mehran; Sadeghi, Narges

doi:10.1016/j.obmed.2019.100165

Cited by 29 publications

(33 citation statements)

References 27 publications

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“…Intervention duration varied from 4 to 12 weeks. Two studies [17, 24] have recruited only males, and the others both genders [15, 16, 18, 19, 25-28]. The dosage of saffron was between 30 and 100 mg/day and crocin ranged from 5 to 30 mg/day.…”

Section: Resultsmentioning

confidence: 99%

“…The dosage of saffron was between 30 and 100 mg/day and crocin ranged from 5 to 30 mg/day. Six [16, 24-28] and three [15, 18, 19] studies used saffron and crocin, respectively, and only one study [17] both crocin and saffron. Participants were selected from individuals with schizophrenia [17], major depressive disorder [25], diabetes mellitus [16, 18, 26, 27], nonalcoholic fatty liver disease [15, 28], and healthy populations [19, 24].…”

Section: Resultsmentioning

confidence: 99%

“…Based on the Cochrane bias assessment tool, four studies ranked as good [16, 25, 26, 28], two as fair [15, 18], and four as poor qualities [17, 19, 24, 27]. Table 2 provides the results of the risk of bias assessment of the included studies.…”

Section: Resultsmentioning

confidence: 99%

“…The effect of saffron consumption on AST was examined in 11 studies [15-18, 24-28]. Overall, meta-analysis revealed that saffron had no beneficial effect on AST (WMD = 0.23 U/L; 95% CI –2.22 to 2.69; p = 0.851) with significant heterogeneity ( I 2 = 74.0%, p < 0.001; Fig.…”

Section: Resultsmentioning

confidence: 99%

“…There was a controversy among studies regarding the effects of saffron consumption on liver function. For example, in one study crocin consumption improved liver function by lowering aspartate transaminase (AST) and alanine aminotransferase (ALT) [15]. In another study, consuming crocin only reduced alkaline phosphatase (ALP) levels [16], but had no significant effect on other enzymes.…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Saffron Consumption on Liver Function: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials

et al. 2021

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Background and Aims: The present systematic review and meta-analysis of randomized controlled trials aimed to determine the effects of saffron supplementation on liver function tests among adults. Methods: Electronic databases including PubMed, ISI Web of Science, and Scopus were searched up to January 2021. The risk of bias in individual studies was assessed using the Cochrane Collaboration tool. The overall estimates and their 95% CIs were calculated using random-effects models. Egger’s test and Begg’s rank-correlation were run to assess the presence of publication bias. p < 0.05 was considered statistically significant. Results: A total of 12 trials involving 608 participants were included in this systematic review and meta-analysis. Saffron supplementation had no significant effect on liver function tests including aspartate transaminase (AST) (weighted mean difference [WMD] = 0.23 U/L; 95% CI –2.22 to 2.69; p = 0.851; I2 = 74.0%), alanine aminotransferase (ALT) (WMD = –1.49 U/L; 95% CI –3.84 to 0.86; p = 0.213; I2 = 60.2%), and alkaline phosphatase (ALP) (WMD = –0.70 U/L; 95% CI –11.35 to 9.95; p = 0.898; I2 = 40.8%) compared to placebo. Conclusion: Based on what was discussed, it seems that saffron supplementation could not improve liver function tests including AST, ALT, and ALP among the adult population. Further clinical trials with larger sample size, longer duration, and higher doses of saffron should be conducted exclusively among patients with liver dysfunction to elucidate the beneficial role of saffron consumption on liver function.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Effect of Saffron Consumption on Liver Function: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials

et al. 2021

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Nutritional supplementation for nonalcohol-related fatty liver disease: a network meta-analysis

Komolafe

Buzzetti

Linden

et al. 2021

Cochrane Database of Systematic Reviews

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Effects of saffron (Crocus sativus L.) on anthropometric and cardiometabolic indices in overweight and obese patients: A systematic review and meta‐analysis of randomized controlled trials

Tahmasbi

Araj‐Khodaei

Mahmoodpoor

et al. 2022

Phytotherapy Research

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The worldwide prevalence of obesity is approximately tripled between 1975 and 2016 according to World Health Organization; therefore, obesity is now considered a global pandemic that needs academic and clinical focus. In search of antiobesity agents, Crocus sativus, known widely as saffron, has been praised for its beneficial effects. Several randomized controlled trials (RCTs) have been conducted to investigate the weight lowering effect of saffron. Following PRISMA guidelines, several medical databases were comprehensively searched for RCTs with a population consisting of obese individuals. A random‐effects meta‐analysis was used to pool estimates across studies, and standardized mean difference (SMD) was used to synthesize quantitative results. Twenty‐five RCTs met the inclusion criteria. Meta‐analysis showed a nonsignificant decrease for weight (−0.32 kg; CI: −3.15, 2.51; p = 0.82), BMI (−0.06 kg/m2;CI:‐1.04,0.93; p = .91), waist circumference (−1.23 cm; CI: −4.14, 1.68; p = .41), and hip circumference (−0.38 cm; CI: −5.99, 5.23; p = .89) and a significant decrease of waist‐to‐hip ratio (SMD = −0.41; CI: −0.73, −0.09; p = .01; I2 = 0%). The mean difference in fasting blood sugar showed a significant reduction in patients with metabolic syndrome (SMD = −0.30; 95% CI: −0.63, 0.03; p = .07; I2 = 0.37%) but a nonsignificant change in the HbA1C level (WMD = 0.05; 95% CI: 0.32, 0.41; p = .79). Despite bearing several limitations, mainly as a result of heterogeneity among included studies, the available evidence indicates saffron supplementation shows promising effects on some cardiometabolic factors among overweight to obese patients; however, further investigations and high‐quality evidence are required for more generalizable and comprehensive results.

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The effects of crocus sativus extract on serum lipid profile and liver enzymes in patients with non-alcoholic fatty liver disease: A randomized placebo-controlled study

Cited by 29 publications

References 27 publications

The Effect of Saffron Consumption on Liver Function: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials

The Effect of Saffron Consumption on Liver Function: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials

Nutritional supplementation for nonalcohol-related fatty liver disease: a network meta-analysis

Effects of saffron (Crocus sativus L.) on anthropometric and cardiometabolic indices in overweight and obese patients: A systematic review and meta‐analysis of randomized controlled trials

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