The Effects of Cyclooxygenase-2 (COX-2) Inhibitor on COX-2 and Prostaglandin E2 Expression in Ovalbumin Induced Early Phase Bronchoconstriction of Rats

Lee, Sung Yong; Lee, Sin Hyung; Jung, Ki Hwan; Kim, Byung Gyu; Jung, Hae Chul; Kim, Kyung Kyu; Kwon, Young Hwan; Kim, Je Hyeong; Lee, Ju Han; Lee, Sang Youb; Cho, Jae Youn; Shim, Jae Jeong; In, Kwang Ho; Yoo, Se Hwa; Kang, Kyung Ho

doi:10.4046/trd.2000.48.2.191

Cited by 1 publication

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“…Various types of LO, such as types 5-, 8-, 9-, 11-, 12-, and type 15-LO, are known so far. Leukotrienes produced by 5-LO in mammals have been reported to play an important role in the development of type I allergy symptoms [28,29]. Therefore, it is judged that substances with selective 5-LO inhibitory activity can be used as a treatment for type I allergy with few side effects.…”

Section: -Lo Inhibitory Effectmentioning

confidence: 99%

Anti-Allergic Effect of Fermented Extracts of Medicinal Plants Andrographis paniculate, Salvia plebeia R. Br., Canavalia gladiate, Eleuthorococcus senticosus, Ulmus davidiana var. japonica, and Clerodendrum trichotomum Thunb. ex Murray

Choi¹,

Kim²

2022

Microbiol. Biotechnol. Lett.

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Since the main symptoms of COVID-19 involve the respiratory system, the infection rate of this disease is predicted to be higher in patients with other respiratory conditions such as allergic rhinitis. In such a situation, it will be meaningful to conduct research on an allergy treatment that has fewer side effects and can effectively reduce allergy symptoms. Here, we prepared experimental samples under various fermentation conditions with mixed extracts of six medicinal plants. To examine the anti-allergic efficacy of these samples, an egg albumin-induced allergic rhinitis animal model experiment, a serum histamine and IgE experiment, and a COX and LO inhibitory activity experiment were conducted. As a result of animal experiments, OVA+SP-4 showed superior efficacy compared to OVA+SP-1 in nasal rubbing and sneezing experiments and had anti-allergic efficacy similar to that of OVA-cetirizine. The serum histamine concentration of OVA+SP-4 was also 1.3 times higher than that of the OVA+cetirizine group, showing a high histamine reduction ability, and IgE showed the same trend. An analysis of COX inhibitory efficacy also confirmed that COX-1 and COX-2 inhibitory efficacy is high, and the longer the fermentation time, the higher the antiallergic efficacy. The composition proposed by this study is expected to have a significant effect on sustainable allergy prevention and treatment in the future by applying it to human patients.

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Section: -Lo Inhibitory Effectmentioning

confidence: 99%