The effects of cysplatin on human adipose tissue derived mesenchymal stromal cells under different oxygen levels

The cell composition of native transplant autosmes (NTA) used for bone plastics was studied. The histological examination showed the fragments of bone beams with preserved osteoblasts, the foci of myeloid and lymphoid hematopoiesis and the fibrin deposits, which suggested the presence of MMSCs. Immunophenotyping of the NTA cell population revealed a high level of expression of the surface markers CD105, CD73, and CD90 characteristic for MMSC. DNA-flow cytometry of the bone dust confirmed almost complete preservation of graft viability on the 3rd day of culturing (97.7 % of live cells). The data of this study confirm the presence of the osteogenic, osteoinductive, and osteoconductive properties of the bone dust and emphasize the importance of a further study of this-type bone graft for use in surgical interventions.

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Analysis of the cellular composition of the native auto-transplantation mixture used for plastics of bone tissue defects

Чуешова

Чешик

Надыров

et al. 2021

Dokl. Akad. nauk

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The effects of cysplatin on human adipose tissue derived mesenchymal stromal cells under different oxygen levels

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References 19 publications

Analysis of the cellular composition of the native auto-transplantation mixture used for plastics of bone tissue defects

Analysis of the cellular composition of the native auto-transplantation mixture used for plastics of bone tissue defects

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