The Effects of Dairy Intake on Insulin Resistance: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Sochol, Kristen M; Johns, Tanya S.; Buttar, Rupinder; Randhawa, Lovepreet; Sanchez, Edeline; Gal, Maya; Lestrade, Katherine; Merzkani, Massini; Abramowitz, Matthew K.; Mossavar‐Rahmani, Yasmin; Melamed, Michal L.

doi:10.3390/nu11092237

Cited by 40 publications

(29 citation statements)

References 100 publications

(185 reference statements)

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“…This nutrient pattern is mostly correlated with dairy intake. Previous studies' findings of the association between dairy consumption and IR are inconsistent [29][30][31]. Although a meta-analysis of clinical trials suggests that dairy intake, especially low-fat dairy, has a beneficial effect on HOMA-IR [30], high dairy intake is reported as a significant predictor of IR in some observational studies [29][30][31].…”

Section: Discussionmentioning

confidence: 98%

A nutrient pattern characterized by vitamin A, C, B6, potassium, and fructose is associated with reduced risk of insulin‐related disorders: A prospective study among participants of Tehran lipid and glucose study

Teymoori

Mokhtari

Salehi

et al. 2021

Diabetol Metab Syndr

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Background Insulin-related disorders, including insulin resistance, insulin insensitivity, and insulinemia, is considered early predictors of major chronic disease risk. Using a set of correlated nutrient as nutrient patterns to explore the diet-disease relationship has drawn more attention recently. We aimed to investigate the association of nutrient patterns and insulin markers’ changes prospectively among adults who participated in the Tehran Lipid and Glucose Study (TLGS). Methods For the present study, 995 men and women aged 30–75 years, with complete information on insulin and dietary intake in survey III TLGS, were selected and followed three years until survey IV. Dietary intakes at baseline were assessed using a valid and reliable food frequency questionnaire (FFQ). Nutrient patterns were derived using principal component analysis (PCA). We extracted five dominant patterns based on the scree plot and categorized them into quartiles. Linear regression analysis was conducted to investigate the association between Nutrient patterns and three-year insulin markers changes, including fasting insulin, HOMA-IR, and HOMA-S. Results The mean (SD) age and BMI of participants (43.1 % male) were 46.2(10.9) year and 28.0(4.7) kg/m2, respectively. The median (IQR, 25, 75) of 3 years changes of insulin, HOMA-IR and HOMA-S were 0.35 (− 1.71, 2.67) mU/mL, 0.25 (− 0.28, 0.84) and − 6.60 (− 22.8, 7.76), respectively. In the fully adjusted model for potential confounders, per each quartile increment of the fifth nutrient pattern, the β coefficients (95 % CI) of changes in insulin, HOMA-IR, and HOMA-S were − 0.36 (− 0.62, − 0.10); P value = 0.007, -0.10 (-0.19, -0.01); P value = 0.022, and 1.92 (0.18, 3.66); P value = 0.030, respectively. There were no significant association between other nutrient patterns and insulin related indices. Conclusions Present study showed that high adherence to a nutrient pattern rich in vitamin A, vitamin C, pyridoxine, potassium, and fructose is inversely associated with 3-years changes in insulin, HOMA-IR, and directly associated with HOMA-S.

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Section: Discussionmentioning

confidence: 98%

A nutrient pattern characterized by vitamin A, C, B6, potassium, and fructose is associated with reduced risk of insulin‐related disorders: A prospective study among participants of Tehran lipid and glucose study

Teymoori

Mokhtari

Salehi

et al. 2021

Diabetol Metab Syndr

View full text Add to dashboard Cite

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“…The observation was confirmed by a meta-analysis of 30 randomized clinical trials. It demonstrated that the consumption of dairy products, especially low-fat ones, was beneficial in terms of tissue insulin sensitivity [12]. However, the results of some studies suggested that only long-lasting consumption of dairy products might have a beneficial effect on insulin sensitivity in tissues.…”

Section: Dairy Products and Insulin Resistancementioning

confidence: 99%

Milk and Dairy Products and Their Impact on Carbohydrate Metabolism and Fertility—A Potential Role in the Diet of Women with Polycystic Ovary Syndrome

2020

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Milk and dairy products are considered an important component of healthy and balanced diet and are deemed to exert a positive effect on human health. They appear to play a role in the prevention and treatment of carbohydrate balance disturbances. The products include numerous valuable components with a potential hypoglycemic activity, such as calcium, vitamin D, magnesium and probiotics. Multiple authors suggested that the consumption of dairy products was negatively associated with the risk of type 2 diabetes mellitus, insulin resistance and ovulation disorders. However, there are still numerous ambiguities concerning both the presumed protective role of dairy products in carbohydrate metabolism disorders, and the advantage of consuming low-fat dairy products over high-fat ones, especially in women with the risk of ovulation disorders. Therefore, this literature review aims at the presentation of the current state of knowledge concerning the relationship between dairy product consumption and the risk of insulin resistance, type 2 diabetes mellitus in women, and the potential effect on the course of polycystic ovary syndrome.

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“…It has been shown that mitochondrial matrix calcium has a regulatory effect on sirtuin expression [46]. The effect of calcium intake on different aspects of diabetes including body weight and insulin resistance has been vastly studied [47][48][49] but still is controversial [50]. It is noteworthy that the mean calcium intake in our participants was about 700 mg/d, considerably less than the recommended intake for this age group.…”

Section: Discussionmentioning

confidence: 75%

The Effect of Daily Intake of Vitamin D-Fortified Yogurt Drink, With and Without Added Calcium, on Serum Adiponectin and Sirtuins 1 and 6 in Adult Subjects with Type 2 Diabetes

Nikooyeh

Hollis

Neyestani

2020

Preprint

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BackgroundThere is evidence suggesting an effect of vitamin D on glycemic status through mediators including adiponectin and sirtuins.ObjectiveTo evaluate the effects of daily intake of vitamin D-fortified yogurt drink, either with or without added calcium, on serum adiponectin, sirtuins (SIRT)1 and 6. DesignBriefly, 75 adults aged 30-60 yrs from both sexes with type 2 diabetes were randomly allocated to one of the three groups: (i) D-fortified-yogurt drink (DY; containing 1000 IU vitamin D and 300 mg calcium), (ii) Ca+D-fortified-yogurt drink (CDY; containing 1000 IU vitamin D and 500 mg calcium) and (iii) plain yogurt drink (PY; containing no detectable vitamin D and 300 mg calcium). All assessments were performed initially and after 12 weeks. ResultsA significant within-group increment in serum adiponectin concentrations was observed in both DY and CDY groups (+60.4± 8.6, +57.5± 6.4 µg/L, respectively; p<0.001 for both). The concentrations of SIRT1 and SIRT6 had a significant within-group increment only in the CDY group (p=0.003, p=0.001 respectively). Being in CDY group was more favorable predictor of improvement in SIRT6 concentrations. Changes of 25(OH)D was a significant predictor of changes of adiponectin. However, this association disappeared following adjustment for changes of SIRT1. In contrast, the association between changes of 25(OH)D and HbA1c remained significant even after adjustment for SIRT1. ConclusionDaily consumption of vitamin D-fortified yogurt drink for 12 weeks resulted in an increase in circulating concentrations of SIRT1 and SIRT6 in T2D subjects and D+Ca-fortified yogurt drink was more in favor of SIRT6 increment.

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The Effects of Dairy Intake on Insulin Resistance: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Cited by 40 publications

References 100 publications

A nutrient pattern characterized by vitamin A, C, B6, potassium, and fructose is associated with reduced risk of insulin‐related disorders: A prospective study among participants of Tehran lipid and glucose study

A nutrient pattern characterized by vitamin A, C, B6, potassium, and fructose is associated with reduced risk of insulin‐related disorders: A prospective study among participants of Tehran lipid and glucose study

Milk and Dairy Products and Their Impact on Carbohydrate Metabolism and Fertility—A Potential Role in the Diet of Women with Polycystic Ovary Syndrome

The Effect of Daily Intake of Vitamin D-Fortified Yogurt Drink, With and Without Added Calcium, on Serum Adiponectin and Sirtuins 1 and 6 in Adult Subjects with Type 2 Diabetes

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