The Effects of Dairy Product Supplementation on Bone Health Indices in Children Aged 3 to 18 Years: A Meta-Analysis of Randomized Controlled Trials

Hidayat, Khemayanto; Zhang, Lili; Rizzoli, René; Guo, Yaxin; Zhou, Yan; Shi, Yujie; Su, Hong-Wen; Liu, Biao; Qin, Li–Qiang

doi:10.1016/j.advnut.2023.06.010

Cited by 9 publications

(3 citation statements)

References 66 publications

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“…The results of the current study did not show that the usual calcium intake had an impact on BMAD in both groups, which is consistent with the results of others indicating that (1) dietary calcium intake itself is a less important (although still significant) predictor of total body bone mass [54]; (2) seasonal fluctuations in calcium absorption in the intestines do not affect bone turnover [42]; (3) additional intake of dairy products has a small effect on bone mineral mass in adolescents [55].…”

Section: Nutrients and Bone Mineral Densitysupporting

confidence: 88%

The Relationship between Bone Health Parameters, Vitamin D and Iron Status, and Dietary Calcium Intake in Young Males

Malczewska-Lenczowska,

Surała,

Granda

et al. 2024

Nutrients

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Vitamin D, calcium, and iron are micronutrients crucial for bone health. However, their effect has been studied primarily in the cortical bone, with vitamin D status being assessed mainly from the total 25(OH)D serum fraction. The study aimed to investigate the impact of vitamin D (total and free fraction) and iron status (i.e., serum ferritin or soluble transferrin receptor) and calcium intake (ADOS-Ca questionnaire) on lumbar cortical and trabecular bone. In a cohort of 113 male subjects (76 athletes, 37 non-athletes) aged 15–19, the lumbar spine status (Z-score, bone mineral apparent density (BMAD), and trabecular bone score (TBS)) was determined using dual-energy X-ray absorptiometry (DXA). Relationships between the examined micronutrients and bone health parameters were observed only in athletes. Free 25(OH)D was significantly (p < 0.001) correlated with Z-score and BMAD, while total 25(OH)D (p < 0.001) and iron status (ferritin, Fe stores; p < 0.01) correlated solely with BMAD. Free 25(OH)D and ferritin concentrations were the best determinants of bone status (R2 = 0.330; p < 0.001) and explained 25% and 7% of the BMAD variance, respectively. No relationships were found between the micronutrients and TBS. The results confirmed the positive influence of vitamin D and iron on cortical, but not trabecular, bone status solely in physically active subjects. In athletes, free 25(OH)D seems to be a superior indicator of bone health to a total 25(OH)D fraction.

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Section: Nutrients and Bone Mineral Densitysupporting

confidence: 88%

The Relationship between Bone Health Parameters, Vitamin D and Iron Status, and Dietary Calcium Intake in Young Males

Malczewska-Lenczowska,

Surała,

Granda

et al. 2024

Nutrients

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“…Indeed, 1 l of standardized cow milk provides 1200 mg/l calcium, 1150 mg/l phosphorus, 32--35 g/l protein, that is casein and whey proteins, which also contain a series of cellular growth factors, together with calories, trace elements and vitamins [ 21 ]. The question of the effect of dairy products supplementation on bone mass accrual was specifically addressed in a meta-analysis including the results of randomized controlled trials conducted in children and adolescents [ 22 ▪ ]. Though of small amplitude, differences in BMD and BMC changes at the level of whole body, lumbar spine, femoral neck and total hip were significantly higher in subjects with dairy products supplementation.…”

Section: Dairy Productsmentioning

confidence: 99%

Bone health: biology and nutrition

Rizzoli,

Chevalley

2023

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Purpose of review Recent findings in the influence of dietary patterns, dairy products, beverages and microbiota composition and function on bone health are reviewed and discussed. Recent findings Evidence is accumulating on the increased risk of fracture in individuals following a vegan diet. Meta-analysis of randomized controlled trials indicates a favourable, though of low amplitude, effect of dairy products on bone mass accrual during childhood and adolescence. Though mostly based on results from observational studies, it seems that dairy product consumption, particularly fermented dairy products, is associated with a lower risk of hip fracture. Regular green tea drinkers may have a lower fracture risk than tea abstainers. Magnesium intake is beneficial for bone health. Prune supplements prevents bone loss in untreated postmenopausal women. This seems to be associated with modification of gut microbiota. Summary This information should help the medical practitioners facing questions from their patients on how to protect bone health through nutrition.

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“…Both lung function and bone density are critical markers of overall health in young populations, with potential implications for their long-term well-being. [ 15 ] Examining the associations of lung function and bone metabolism may pave the way for more holistic health strategies and interventions tailored specifically for children and adolescents. Hence, the core objective of this research is to delve deeply into the intricate relationship between lung function and bone density in children and adolescents.…”

Section: Introductionmentioning

confidence: 99%

Association between lung function and bone mineral density in children and adolescents: Insights from the NHANES

Zhou,

Zeng,

Chen

et al. 2024

Medicine

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Bone development and lung function are integral to child and adolescent health. Both influence an individual’s overall well-being and potentially affect long-term health. Utilizing a comprehensive dataset from the National Health and Nutrition Examination Survey, this study aims to elucidate the relationship between lung function and bone mineral density (BMD) in a representative sample of children and adolescents. The analysis covered 3410 participants aged 8 to 19 years. We employed weighted multivariate linear regression and restricted cubic spline curve visualizations to explore the intricate association between lung function metrics, particularly first-second expiratory volume 1 second/forced vital capacity ratio, and lumbar BMD. Our data indicated a positive association between lung function and lumbar BMD in children and adolescents. Specifically, higher lung function metrics were linked with increased lumbar BMD. This association was more pronounced in younger participants or those with a lower body mass index. A significant positive relationship exists between lung function and BMD in the pediatric population. Recognizing this association is crucial for holistic health strategies for children and adolescents. This study underscores the need for integrated health monitoring during formative years, which can influence health trajectories as these individuals transition to adulthood.

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The Effects of Dairy Product Supplementation on Bone Health Indices in Children Aged 3 to 18 Years: A Meta-Analysis of Randomized Controlled Trials

Cited by 9 publications

References 66 publications

The Relationship between Bone Health Parameters, Vitamin D and Iron Status, and Dietary Calcium Intake in Young Males

The Relationship between Bone Health Parameters, Vitamin D and Iron Status, and Dietary Calcium Intake in Young Males

Bone health: biology and nutrition

Association between lung function and bone mineral density in children and adolescents: Insights from the NHANES

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