The effects of desert dust storms, air pollution, and temperature on morbidity due to spontaneous abortions and toxemia of pregnancy: 5-year analysis

Boğan, Mustafa; Al, Behçet; Kül, Seval; Zengin, Suat; Oktay, Murat; Sabak, Mustafa; Gümüşboğa, Hasan; Bayram, Hasan

doi:10.1007/s00484-021-02127-8

Cited by 19 publications

(13 citation statements)

References 37 publications

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“…Several studies have reported that exposure to air pollution during pregnancy increases the risk of spontaneous abortion [5,49,50]. Gaskins et al reported that 1-year and 2-year exposures to PM2.5-10 prior to pregnancy were associated with a higher risk of spontaneous abortion [6].…”

Section: Discussionmentioning

confidence: 99%

Integrated single-cell RNA-seq and DNA methylation reveal the effects of air pollution in patients with recurrent spontaneous abortion

Zhu

et al. 2022

Clin Epigenet

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Background Maternal air pollutants exposure is associated with a number of adverse pregnancy outcomes, including recurrent spontaneous abortion (RSA). However, the underlying mechanisms are still unknown. The present study aimed to understand the mechanism of RSA and its relationship with air pollution exposure. We compared data of decidual tissue from individuals with induced abortions and those with RSA by bulk RNA sequencing (RNA-seq), reduced representation bisulfite sequencing (RRBS), and single-cell RNA sequencing (scRNA-seq). Differentially expressed genes (DEGs) were verified using RT-qPCR and pyrosequencing. A logistic regression model was used to investigate the association between air pollutants exposure and RSA. Results We identified 98 DEGs with aberrant methylation by overlapping the RRBS and RNA-seq data. Nineteen immune cell subsets were identified. Compared with normal controls, NK cells and macrophages accounted for different proportions in the decidua of patients with RSA. We observed that the methylation and expression of IGF2BP1 were different between patients with RSA and controls. Furthermore, we observed significant positive associations between maternal air pollutants exposure during the year prior to pregnancy and in early pregnancy and the risk of RSA. Mediation analyses suggested that 24.5% of the effects of air pollution on the risk of RSA were mediated through IGF2BP1 methylation. Conclusion These findings reveal a comprehensive cellular and molecular mechanism of RSA and suggest that air pollution might cause pregnancy loss by affecting the methylation level of the IGF2BP1 promoter.

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Section: Discussionmentioning

confidence: 99%

Integrated single-cell RNA-seq and DNA methylation reveal the effects of air pollution in patients with recurrent spontaneous abortion

Zhu

et al. 2022

Clin Epigenet

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“…It is known that the inhalation of pollutants dispersed in the atmosphere adversely affects human health (4)(5)(6)(7)(8)(9)(10). High level of car traffic, increased combustion of fossil fuels for industrial activities, transport, and domestic heating lead to elevated levels of air pollutants including particulate matter (PM) levels in the atmosphere (4).…”

Section: Introductionmentioning

confidence: 99%

“…High level of car traffic, increased combustion of fossil fuels for industrial activities, transport, and domestic heating lead to elevated levels of air pollutants including particulate matter (PM) levels in the atmosphere (4). Air pollution causes human health problems such as respiratory, cardiovascular, cerebrovascular, and obstetric diseases (4,5,(7)(8)(9)(10)(11). Basic biological mechanisms that explain the effects of air pollutants on vascular structures are still controversial (3).…”

Section: Introductionmentioning

confidence: 99%

Impact of desert dust storms, PM10 levels and daily temperature on mortality and emergency department visits due to stroke

Oktay,

Al,

Boğan

et al. 2023

Front. Public Health

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ObjectiveIt is known that the inhalation of air pollutants adversely affects human health. These air pollutants originated from natural sources such as desert storms or human activities including traffic, power generating, domestic heating, etc. This study aimed to investigate the impacts of desert dust storms, particulate matter ≤10 μm (PM10) and daily maximum temperature (MT) on mortality and emergency department (ED) visits due to stroke in the city of Gaziantep, Southeast Turkey.MethodThe data on mortality and ED visits due to stroke were retrospectively recruited from January 1, 2009, to March 31, 2014, in Gaziantep City Centre.ResultsPM10 levels did not affect ED visits or mortality due to stroke; however, MT increased both ED visits [adjusted odds ratio (OR) = 1.002, 95% confidence interval (CI) = 1.001–1.003] and mortality (OR = 1.006, 95% CI = 0.997–1.014) due to stroke in women. The presence of desert storms increased ED visits due to stroke in the total population (OR = 1.219, 95% CI = 1.199–1.240), and all subgroups. It was observed that desert dust storms did not have an increasing effect on mortality.ConclusionOur findings suggest that MT and desert dust storms can induce morbidity and mortality due to stroke.

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“…Epidemiological studies have demonstrated that there is a direct link between exposure to high amounts of dust particles and the number of daily hospitalizations and deaths (Karanasiou et al 2012;Rublee et al, 2020;Herrera-Molina et al, 2021). Exposure to dust particles during dust events can cause respiratory and cardiovascular problems (Zhang et al, 2016;Toure et al, 2019;Rublee et al, 2020); increase the probability of low birth weight and premature birth (Dastoorpoor et al, 2018;Jones, 2020;Bogan et al, 2021); cause different diseases, such as meningitis (Diokhane et al, 2016) and valley fever (Middleton, 2020); and, in rare cases, end in death (Crooks et al, 2016;Zhang et al, 2016). Information on the increase in particle concentrations and the change in particle sizes with the degradation of air quality during dust events can help develop an understanding of the impact that these events have on people who are exposed to them.…”

Section: Introductionmentioning

confidence: 99%

Particle size distribution and particulate matter concentrations during synoptic and convective dust events in West Texas

Ardon‐Dryer

Kelley

2022

Atmos. Chem. Phys.

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Abstract. Dust events are an important and complex constituent of the atmospheric system that can impact Earth's climate, the environment, and human health. The frequency of dust events in the Southern High Plains of West Texas has increased over the past 2 decades, yet their impact on air quality in this region is still unclear. This is due to the fact that there is only one air quality monitoring station that measures only PM2.5 concentrations (particulate matter with an aerodynamic diameter < 2.5 µm), and there is no information on other PM sizes or the particle size distribution. The Aerosol Research Observation Station (AEROS) unit provides insight into the local variation in particle concentration during different dust events and allows for a better understanding of the impact of dust events on air quality. As this area is prone to dust events, we were wondering if dust events generated by different meteorological causes (synoptic vs. convective) would present similar particle concentrations or particle size distributions. Thus, in this project, three different dust events were measured by AEROS and compared. Each dust event originated from a different direction and lasted a different duration. One of the dust events was synoptic (10 April 2019) and two were convective (5 and 21 June 2019). Measurements of particle mass and number concentration, size distribution, and meteorological conditions for each dust event were compared. The synoptic dust event (on 10 April) was longer (12 h) and had stronger wind speed conditions (up to 22.1 m s−1), whereas the two respective convective dust events on 5 and 21 June lasted only 20 and 30 min and had lower wind speeds (up to 16.5 and 13.4 m s−1). Observation of PM based on daily and hourly values showed an impact on air quality, yet measurements based on daily and hourly values underestimate the impact of the convective dust events. Observations based on a shorter timescale (10 min) reveal the true impact of the two convective dust events. A comparison of the particle size distribution showed that all three dust events presented an increase in particles in the 0.3–10 µm size range. Comparisons of the particle concentration for particles > 5 and > 10 µm show very high values during the dust events. Some particle sizes even increase in concentration by ∼ 2 orders of magnitude compared with the time before the dust event. This leads us to speculate that the impact of convective dust events on air quality in this region is underestimated with the current (hourly basis) method.

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The effects of desert dust storms, air pollution, and temperature on morbidity due to spontaneous abortions and toxemia of pregnancy: 5-year analysis

Cited by 19 publications

References 37 publications

Integrated single-cell RNA-seq and DNA methylation reveal the effects of air pollution in patients with recurrent spontaneous abortion

Integrated single-cell RNA-seq and DNA methylation reveal the effects of air pollution in patients with recurrent spontaneous abortion

Impact of desert dust storms, PM10 levels and daily temperature on mortality and emergency department visits due to stroke

Particle size distribution and particulate matter concentrations during synoptic and convective dust events in West Texas

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