The Effects of Desflurane and Propofol on the Release of Thyroid Hormones in Euthyroid Patients Undergoing Elective Lumbar Discectomy

Şentürk, Burçak; Umuroğlu, Tümay; Saraçoğlu, Ayten; Etı, Zeynep; Göğüş, F. Yılmaz

doi:10.5152/tjar.2014.66934

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…In this study, patients with propofol anesthesia showed higher serum T4 levels at 3 months post‐operatively, compared to patients with sevoflurane anesthesia, and there was a significant group‐by‐time interaction. In contrast, previous clinical studies of patients undergoing lumbar discectomy or gynecological laparoscopy showed that serum‐free T4 levels did not differ at 4 or 24 hours post‐operatively between patients anesthetized with sevoflurane or desflurane and those anesthetized with propofol 10,20 . This discrepancy was presumably due to the effects of other confounders (i.e., pre‐operative thyroid function status, including serum‐free T4 level and the number of patients with TSH deficiency), rather than the effects of anesthetics.…”

Section: Discussionmentioning

confidence: 65%

Effects of anesthetics on post‐operative 3‐month neuroendocrine function after endoscopic transsphenoidal non‐functional pituitary adenoma surgery

Yhim

Yoon

et al. 2020

Acta Anaesthesiol Scand

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Background: Anesthetic techniques can affect perioperative neuroendocrine function. The objective of this study was to compare 3-month post-operative neuroendocrine functional outcomes between sevoflurane and propofol anesthesia in patients undergoing endoscopic transsphenoidal surgery (ETS) for removal of non-functional pituitary adenomas (NFPAs) retrospectively. Methods: Among 356 patients who underwent ETS for removal of NFPAs under sevoflurane-remifentanil anesthesia (sevoflurane group, n = 103) or propofolremifentanil anesthesia (propofol group, n = 253), 92 patients in each group were selected and their 3-month post-operative neuroendocrine functional outcomes (primary outcome measure) were compared after propensity score matching. Results: Overall changes in post-operative 3-month neuroendocrine function compared to pre-operative baseline did not differ between the sevoflurane and propofol groups (worsened: 32.6% vs 29.3%, persistently decreased: 9.8% vs 12.0%, improved: 12.0% vs 20.7%, normalized: 9.8% vs 12.0%, persistently normal: 18.5% vs 19.6%; P = .400). The incidence of pituitary hormone deficiency at 3 months postoperatively did not differ between the sevoflurane and propofol groups (adreno

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Section: Discussionmentioning

confidence: 65%

Effects of anesthetics on post‐operative 3‐month neuroendocrine function after endoscopic transsphenoidal non‐functional pituitary adenoma surgery

Yhim

Yoon

et al. 2020

Acta Anaesthesiol Scand

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“…Although taking into consideration the different conditions of exposures and the remarkable inter-subject variability, the thyroid is very sensitive to the action of chemical disruptors [43]. Therefore, it cannot be ruled out that physicians, e.g., anesthesiologists and surgeons, employees in rubber and ceramic industry, as well as those involved in the packaging units of a pharmaceutical industry, may be exposed to chemicals, e.g., anesthetics, metals and plasticizers that may mediate hormonal alterations as reported in occupational, epidemiological and experimental settings [44][45][46][47][48][49].…”

Section: Discussionmentioning

confidence: 99%

The Impact of Shift-Work and Night Shift-Work on Thyroid: A Systematic Review

Leso

Vetrani

Sicignano

et al. 2020

IJERPH

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Thyroid hormones are regulated by the pituitary thyroid stimulating hormone (TSH), whose secretion presents a circadian rhythmicity. Indeed, it is conceivable that shift- and night shift-work, affecting sleep-wake rhythms, may impact thyroid functionality. Therefore, the aim of the present review was to provide an overview on the association between shift- and night shift-work and thyroid hormonal changes and disease development. A systematic review of studies available in PubMed, Scopus, and ISI Web of Science databases was performed. A positive association between night shift-work and increased TSH concentrations was reported by most of the reviewed investigations. Inconclusive evidence was available on thyroid diseases. However, the limited number of studies, the noticeable heterogeneity in the shift-work scheduling, in terms of amount, duration, type of shift- or night shift-work, prevents easily integrating findings and extrapolating definite conclusions. Further investigation seems necessary to better define the relationship between shift schedules and different thyroid outcomes, and possible long-term implications of early functional changes. Overall, this may support the adoption of advanced risk assessment and management strategies aimed to achieve a safer workplace organization and a timely, responsible realization of all the benefits of a 24-h economy.

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“…A study compared the impact of desflurane and propofol on thyroid hormone levels in euthyroid patients. There was no significant difference in the release of TSH, FT3 and FT4 between the two anesthetics [21]. Consequently, which anesthetic induces a more intensive impact on the pituitary thyroid axis should be researched further.…”

Section: Plos Onementioning

confidence: 91%

Propofol suppresses hormones levels more obviously than sevoflurane in pediatric patients with craniopharyngioma: A prospective randomized controlled clinical trial

et al. 2023

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Objective General anesthesia can disturb the hormone levels in surgical patients. Hormone deficiency is one of the major symptoms of craniopharyngioma (CP) in pediatric patients. The aim of this prospective randomized controlled clinical study is to evaluate whether propofol and sevoflurane influence the perioperative hormone levels in these patients and to determine which anesthesia technique causes less impact on hormone levels. Materials Sixty-four ASA I and II pediatric patients with CP undergoing elective neurosurgery were randomly divided into the sevoflurane group (S group, n = 32) and the propofol group (P group, n = 32). Anesthesia was maintained with sevoflurane and propofol until the end of the operation. Demographic information, operation information and hemodynamic variables were recorded. The levels of hormones were evaluated preoperatively as the baseline (T0), 1h after the beginning of the operation (T1), immediately at the end of the operation (T2) and 72 h postoperatively (T3). Results There were no significant differences in the two groups in terms of patients’ demographics and intraoperative information, such as operation duration, blood loss and transfusion volumes, and fluid infusion volume (P>0.05). In both groups, compared to those at T0, the levels of TSH, FT3, TT3 and ACTH at T1, T2 and T3 were significantly lower. The levels of FSH, PRL and GH at T3 were also significantly lower (P<0.05). The FT3 and TT3 levels of both groups at T2 and T3 were significantly lower than those at T1, but the ACTH level was significantly increased (P<0.05). Compared to the levels at T2, the TSH, FT3, FT4 and ACTH levels of the two groups at T3 were significantly reduced (P<0.05). The baseline hormone levels of both groups were similar (P>0.05). At T1, the FT3, TT3, FT4, TT4 and ACTH levels in the P group were significantly lower than those in the S group (P<0.05). At T2, the TT3 and ACTH levels of the P group were significantly lower than those of the S group (P<0.05) At T3, the TT4 level in the P group was significantly lower than that of the S group (P<0.05). Conclusion Propofol and sevoflurane could reduce the levels of hormones intraoperatively and postoperatively in pediatric patients with craniopharyngioma. However, propofol reduced hormone levels more intensively, mainly intraoperatively. Postoperatively, propofol and sevoflurane had similar inhibition effects on the shift in hormone levels. Therefore, in pediatric patients with craniopharyngioma undergoing neurosurgery, sevoflurane might be the preferred anesthetic because it causes less interruption of hormone levels. However, because of their similar postoperative effects, which long-term effects of sevoflurane or propofol could produce optimal clinical situations? Thus more extensive clinical studies are needed. Trial registration Clinical trial registration. This trail was registered at Chinese Clinical Trial Registry (http://www.chictr.org.cn, Jun Xiong) on 28/12/2021, registration number was ChiCTR2100054885.

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The Effects of Desflurane and Propofol on the Release of Thyroid Hormones in Euthyroid Patients Undergoing Elective Lumbar Discectomy

Cited by 3 publications

References 17 publications

Effects of anesthetics on post‐operative 3‐month neuroendocrine function after endoscopic transsphenoidal non‐functional pituitary adenoma surgery

Effects of anesthetics on post‐operative 3‐month neuroendocrine function after endoscopic transsphenoidal non‐functional pituitary adenoma surgery

The Impact of Shift-Work and Night Shift-Work on Thyroid: A Systematic Review

Propofol suppresses hormones levels more obviously than sevoflurane in pediatric patients with craniopharyngioma: A prospective randomized controlled clinical trial

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