The Effects of Developmental Programming upon Neonatal Mortality

Perry, V.E.A.; Copping, K. J.; Miguel-Pacheco, Giuliana G.; Medrano, Juan

doi:10.1016/j.cvfa.2019.02.002

Cited by 12 publications

(8 citation statements)

References 97 publications

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“…The poor intrauterine environment caused by GDM and preeclampsia induces changes in fetal DNA methylation patterns related to fat synthesis, leading to abnormal NBW [8]. Dyslipidemia is an important risk factor affecting the growth and development of the fetus and may also be the critical pathogenesis of GDM with co-existent preeclampsia (GCP) [9,10].…”

Section: Introductionmentioning

confidence: 99%

Association Between Maternal Glucose/Lipid Metabolism Parameters and Abnormal Newborn Birth Weight in Gestational Diabetes Complicated by Preeclampsia: A Retrospective Analysis of 248 Cases

Xiao

Zhang

2020

Diabetes Ther

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Introduction: Women with gestational diabetes mellitus (GDM) with co-existent preeclampsia (GCP) are at increased risk of giving birth to a baby with an abnormal birth weight. We have analyzed the risk factors for abnormal newborn birth weight (NBW) in women with co-presence of GDM and GCP, focusing on maternal glucose/lipid metabolism, with the aim to optimize the clinical intervention strategy. Methods: The clinical data of 248 pregnant women with GCP and their infants were retrospectively analyzed through a comprehensive review of the electronic medical records of Women and Children's Hospital, Xiamen University (Xiamen, China). These women had received prenatal care and had their baby delivered in the hospital between January 2016 and November 2018. Major characteristics assessed were large for gestational age (LGA), small for gestational age (SGA), severe preeclampsia (S-PE), and maternal plasma glucose/lipid profile in late pregnancy. Secondary characteristics were maternal age, height, body mass index (BMI), gestational weight gain (GWG), abortion history, education level, primipara or not, preterm or not, and fetal gender. Regression analysis was used to analyze the association between maternal glucose/lipid metabolism parameters and LGA or SGA. Results: There was no difference in the ratio of advanced maternal age, primipara, abortion history, preterm delivery, and newborn sex between the control group and the LGA or SGA group. Logistic regression analysis, with such factors as maternal stature, BMI, among others, was applied. Multivariate analysis of SGA infants revealed the following associations: S-PE (odds ratio [OR] 3.226, 95% confidence interval [CI] 1.385-7.515; adjusted OR [AOR] 3.675, 95% CI 1.467-9.207; p \ 0.05); high levels of glycated hemoglobin (HbA1c [ 6.5%) (OR 0.436, 95% CI 0.187-1.017; AOR 0.459, 95% CI 0.179-1.173; p [ 0.05); low levels of high-density lipoprotein cholesterol (HDL-C \ 1.0 mmol/L) (OR 0.625, 95% CI 0.287-1.361; AOR 0.637, 95% CI 0.267-1.520; p [ 0.05). Multivariate analysis of LGA revealed the following associations: S-PE (OR 30.885, 95% CI 0.398-2.013; AOR 0.974, 95% CI 0.400-2.371; p [ 0.05); high levels of HbA1c (OR 4.542, 95% CI 0.187-11.824; AOR 3.997, 95% CI 1.452-10.998; p \ 0.05); low Yunshan Xiao and Xueqin Zhang contributed equally to this work and should be considered co-first authors.

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Section: Introductionmentioning

confidence: 99%

Association Between Maternal Glucose/Lipid Metabolism Parameters and Abnormal Newborn Birth Weight in Gestational Diabetes Complicated by Preeclampsia: A Retrospective Analysis of 248 Cases

Xiao

Zhang

2020

Diabetes Ther

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“…For example, our current knowledge indicates that foetal programming and calfhood performance (e.g. Hayes et al, 2021) have significant impacts on lifetime productivity (Berry et al, 2008), reproductive performance (Cushman & Perry, 2019), health (Perry et al, 2019) and longevity (Berry et al, 2008). Sixty years ago, perinatal health research was confined to effects in humans, for example, the Barker hypothesis (Barker et al, 1989).…”

Section: Perinatal Dairy Calf Healthmentioning

confidence: 99%

Ruminant health research – progress to date and future prospects, with an emphasis on Irish research

Mee

Barrett

Boloña

et al. 2022

Irish Journal of Agricultural and Food Research

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This review addresses the progress that has been made in ruminant health research over the last 60 yr, with an emphasis on Irish research. The review focuses on the economically important infectious diseases of dairy and beef cattle and of sheep, calf diseases, regulated and non-regulated infectious diseases, lameness, mastitis and parasitoses. The progress to date, current knowledge and future challenges are all addressed. Paradigm shifts have occurred in many of these diseases, the most profound of which is the change from increasing antimicrobial usage (AMU) to the realisation of the challenge of antimicrobial resistance (AMR) and the current reduction in AMU. Another major change in thinking is the move away from focus on the pathogen exclusively towards a more holistic view of the roles of host immunity and adequacy of management. In the last 60 yr, many new diseases have emerged but in parallel many new technologies have rapidly evolved to monitor and control these threats to animal health. Irish research has contributed substantially to improved current ruminant health. The major future challenge is how to manage ruminant health in a OneHealth world where animal, human and environmental health and sustainability are intimately intertwined and interdependent.

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“…Специфіка нервової системи у них сприяє підвищенню частоти дихання і посиленню серцево-судинної діяльності, а енергетичний обмін переважає над пластичним (Wang et al, 2019). У тварин травного типу відповідно менше забезпечення кисню на 1 кг живої маси, обмін речовин повільніший, за нервовою діяльністю тварини флегматичніші, що спрямовано на відкладання речовин про запас (жири, білки, вуглеводи), в їх організмі більше виражений пластичний обмін (Perry et al, 2019;Hales & Old, 2019).…”

Section: обговоренняunclassified

The economic traits of cows with different types of constitution

Chernenko¹,

Chernenko²,

Mylostyvyi³

et al. 2020

TAVM

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Presented study results of the influence of constitution types on economically useful traits of highly productive Swiss breed. The experimental animals were divided into three groups according to the standard deviation of 0.67 from the average value of the volume-to-weight coefficient (VWC) for the studied group of same-aged animals at the calving. To the low-volume type with VWC value of less than 0.46 l/kg 16 cows were allocated, to the medium-volume type with VWC of 0.46 to 0.56 l/kg-44 cows respectively, and to the large-volume type with VWC value, which amounted to 0.57 l/kg or more-19 cows. Since the difference in animals' bodyweight of all groups was within 3%, which is a characteristic of matched pairs design, in cows with the constitution of large and medium volume type per kg of their body weight, there was a greater ratio of the thorax which is characterizing volume-to-weight coefficient value. Experimental cows by the main measurements of the exterior were characterized by good development. However, animals of the high and mid-volume type of constitution had deep and wide chests, with a larger chest crosssectional area behind the shoulder blades and behind the last rib, and a larger conditional volume of the whole thorax. The skin on the neck and the last rib turned out to be the most informative for the definition of the body types features. The cows of those constitution types had thinner skin on the neck by 0.4 (P > 0.95) and 0.3 cm (approximately P > 0.95), and at the level of the last rib by 0.3 (approximately P > 0 95) and 0.5 cm (P > 0.95) compared to the low volume type of constitution. According to body indices, cows of all body types had a pronounced and consolidated dairy type. This was evidenced by the low value of the variability coefficient of the exterior indices in the range of 2.2-6.9%. Compared to cows of low volume type, a statistically significant difference was found in favor of cows with the high and medium-volume type of the constitution by chest width index, respectively, by 1.9% (P > 0.999) and 1.8% (P > 0.999) and backside index, respectively: 2,4% (P > 0.99) and 1.0% (P > 0.95). No correlation was found between the cows' behaviour and their type of constitution. It has been established that cows' milk productivity depends on the development of the thorax as a whole and the value of the volume-to-weight coefficient in particular. High and medium-volume type cows for 305 days of the first lactation had higher milk yields by 1 314 kg (P > 0.95), milk fat yield-by 41.6 kg (P > 0.95), and milk protein yield-by 40.8 kg (P > 0.95). There was a similar difference for the second lactation.

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The Effects of Developmental Programming upon Neonatal Mortality

Cited by 12 publications

References 97 publications

Association Between Maternal Glucose/Lipid Metabolism Parameters and Abnormal Newborn Birth Weight in Gestational Diabetes Complicated by Preeclampsia: A Retrospective Analysis of 248 Cases

Association Between Maternal Glucose/Lipid Metabolism Parameters and Abnormal Newborn Birth Weight in Gestational Diabetes Complicated by Preeclampsia: A Retrospective Analysis of 248 Cases

Ruminant health research – progress to date and future prospects, with an emphasis on Irish research

The economic traits of cows with different types of constitution

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