The effects of different drying methods on the morphology and physical properties of mesoporous silica nanoparticles

Aguirre-Sánchez, Andrés S.; Abril-Martínez, Fausto; Bernal-Ramírez, Judit

doi:10.1016/j.matpr.2019.03.160

Cited by 3 publications

(4 citation statements)

References 10 publications

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“…Thus, the conventional oven-drying was shown inadequate for drying MNP dispersions compared to the electrospinning method. The reason could be the exposure of MNP dispersion to high temperature (i.e., 90 • C) during drying and longlasting drying process compared to the electrospinning, which could be classified as a non-thermal drying method (Aguirre-Sánchez et al, 2019). During oven-drying MNPs are exposed to instabilities, which result in irreversible particle aggregation and increased mean particle size after their reconstitution.…”

Section: Throughout Evaluation Of the Final Formulationsmentioning

confidence: 99%

“…Thus, different drying methods for the transformation of MNP dispersions in dry products have been investigated in the last two decades (Amstad et al, 2009;Gamarra et al, 2005;Stocke et al, 2015;Vaz-Ramos et al, 2020). The thermal drying methods (e.g., spray-drying) represent a high risk for MNP agglomeration during the drying process, therefore the non-thermal methods (e.g., freeze-drying) are usually preferred (Aguirre-Sánchez et al, 2019). The most commonly used drying method for nanoparticle dispersions in general is freeze-drying (Ataide et al, 2021;Degobert and Aydin, 2021;Mohammady et al, 2020;Trenkenschuh and Friess, 2021).…”

Section: Introductionmentioning

confidence: 99%

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Electrospinning as a method for preparation of redispersible dry product with high content of magnetic nanoparticles

Dragar

Ileršič

Potrč

et al. 2022

International Journal of Pharmaceutics

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Section: Throughout Evaluation Of the Final Formulationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Electrospinning as a method for preparation of redispersible dry product with high content of magnetic nanoparticles

Dragar

Ileršič

Potrč

et al. 2022

International Journal of Pharmaceutics

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“…The dry product was dispersed partially, but agglomerates were still visible to the naked eye, indicating the procedure to be inefficient. The main reason might be the exposure of the sample to 90 °C and the long duration of the drying process, as already described in the literature [ 25 , 31 ]. On the other hand, we managed to reconstitute SPIONs from the lyophilizate, but the SPION hydrodynamic size in the reconstituted dispersion was significantly bigger compared to the SPION hydrodynamic size after their reconstitution from the electrospun products ( Figure 9 a).…”

Section: Resultsmentioning

confidence: 99%

“…In the last two decades, several methods have been developed and investigated to transform nanoparticle dispersion into a stable and easily dispersible dry product. These drying methods include freeze-drying [ 6 , 7 , 9 , 10 , 11 ], spray-drying [ 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 ], spray–freeze drying [ 20 , 21 , 22 ], conventional drying in a heated oven [ 23 , 24 ], alcohol desiccation [ 23 , 25 ], vacuum drying [ 24 ], fluid-bed granulation [ 12 , 26 , 27 , 28 ], fluid-bed pellet coating [ 29 ], and supercritical fluids drying [ 30 ]. However, the majority of these drying methods has certain important limitations, which hinder their broader use in the drying of nanoparticle dispersions.…”

Section: Introductionmentioning

confidence: 99%

Influence of Polymer Concentration on Drying of SPION Dispersions by Electrospinning

Dragar,

Rekar,

Potrč

et al. 2023

Pharmaceutics

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To improve the physical stability of nanoparticle dispersions, several methods for their transformation into stable and easily dispersible dry products have been investigated thus far. Recently, electrospinning was shown to be a novel nanoparticle dispersion drying method, which addresses the crucial challenges of the current drying methods. It is a relatively simple method, but it is affected by various ambient, process, and dispersion parameters, which impact the properties of the electrospun product. The aim of this study was, thus, to investigate the influence of the most important dispersion parameter, namely the total polymer concentration, on the drying method efficiency and the properties of the electrospun product. The formulation was based on a mixture of hydrophilic polymers poloxamer 188 and polyethylene oxide in the weight ratio of 1:1, which is acceptable for potential parenteral application. We showed that the total polymer concentration of prior-drying samples is closely related to their viscosity and conductivity, also affecting the morphology of the electrospun product. However, the change in morphology of the electrospun product does not affect the efficiency of SPION reconstitution from the electrospun product. Regardless of the morphology, the electrospun product is not in powder form and is therefore safer to handle compared to powder nanoformulations. The optimal total polymer concentration in the prior-drying SPION dispersion, which enables the formation of an easily dispersible electrospun product with high SPION-loading (65% (w/w)) and fibrillar morphology, was shown to be 4.2% (w/v).

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Review on Porous Scaffolds Generation Process: A Tissue Engineering Approach

Flores-Jiménez

García-González

Fuentes-Aguilar

2023

ACS Appl. Bio Mater.

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Porous scaffolds have been widely explored for tissue regeneration and engineering in vitro three-dimensional models. In this review, a comprehensive literature analysis is conducted to identify the steps involved in their generation. The advantages and disadvantages of the available techniques are discussed, highlighting the importance of considering pore geometrical parameters such as curvature and size, and summarizing the requirements to generate the porous scaffold according to the desired application. This paper considers the available design tools, mathematical models, materials, fabrication techniques, cell seeding methodologies, assessment methods, and the status of pore scaffolds in clinical applications. This review compiles the relevant research in the field in the past years. The trends, challenges, and future research directions are discussed in the search for the generation of a porous scaffold with improved mechanical and biological properties that can be reproducible, viable for long-term studies, and closer to being used in the clinical field.

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The effects of different drying methods on the morphology and physical properties of mesoporous silica nanoparticles

Cited by 3 publications

References 10 publications

Electrospinning as a method for preparation of redispersible dry product with high content of magnetic nanoparticles

Electrospinning as a method for preparation of redispersible dry product with high content of magnetic nanoparticles

Influence of Polymer Concentration on Drying of SPION Dispersions by Electrospinning

Review on Porous Scaffolds Generation Process: A Tissue Engineering Approach

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