The effects of different training modalities on monocarboxylate transporters MCT1 and MCT4, hypoxia inducible factor-1α (HIF-1α), and PGC-1α gene expression in rat skeletal muscles

Ahmadi, Akbar; Sheikholeslami-Vatani, Dariush; Ghaeeni, Saeed; Baazm, Maryam

doi:10.1007/s11033-021-06224-0

Cited by 9 publications

(6 citation statements)

References 46 publications

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“…In the non-ischemic muscle, we reported no significant effect of three times per week exercise on MCT1 and MCT4 mRNA expression, whilst five times per week exercise significantly downregulated MCT1 expression only. Ahmadi et al recently reported in lower limb muscles of rats that MCT1 and MCT4 mRNA levels did not decrease following an 8-week treadmill running protocol performed at a frequency of five times per week [34]. Interestingly, we observed an almost similar decrease (although not significant) in MCT1 and MCT4 mRNA levels in the ischemic muscle following the two training frequencies.…”

Section: Discussionsupporting

confidence: 67%

Physical Performance and Skeletal Muscle Transcriptional Adaptations Are Not Impacted by Exercise Training Frequency in Mice with Lower Extremity Peripheral Artery Disease

Lavier

Bouzourène²,

Millet

et al. 2023

Metabolites

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Exercise training is an important therapeutic strategy for lower extremity peripheral artery disease (PAD). However, the effects of different exercise frequency on physiological adaptations remain unknown. Thus, this study compared the effects of a 7-week moderate-intensity aerobic training performed either three or five times/week on skeletal muscle gene expression and physical performance in mice with PAD. Hypercholesterolemic male ApoE-deficient mice were subjected to unilateral iliac artery ligation and randomly assigned to sedentary or exercise training regimens either three or five times/week. Physical performance was assessed using a treadmill test to exhaustion. Expression of genes related to glucose and lipid metabolism, mitochondrial biogenesis, muscle fiber-type, angiogenesis, and inflammation was analyzed in non-ischemic and ischemic gastrocnemius muscles by real-time polymerase chain reaction. Physical performance was improved to the same extent in both exercise groups. For gene expression patterns, no statistical differences were observed between three or five times/week exercised mice, both in the non-ischemic and ischemic muscles. Our data show that exercising three to five times a week induces similar beneficial effects on performance. Those results are associated with muscular adaptations that remain identical between the two frequencies.

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Section: Discussionsupporting

confidence: 67%

Physical Performance and Skeletal Muscle Transcriptional Adaptations Are Not Impacted by Exercise Training Frequency in Mice with Lower Extremity Peripheral Artery Disease

Lavier

Bouzourène²,

Millet

et al. 2023

Metabolites

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“…How different biophysical stimuli may affect mitochondrial metabolism bone was recently reviewed by ( Wang F.-S. et al, 2021 ). In rat skeletal muscle tissue, the expression of PGC-1α and HIF-1α were differently affected by the training regimen (continuous, moderate exercise vs high-intensity interval) ( Ahmadi et al, 2021 ). However, regarding bone, there is still limited information on how different loading regimens affect these pathways.…”

Section: Oxidative Stress and Bone Mechanobiologymentioning

confidence: 99%

In Sickness and in Health: The Oxygen Reactive Species and the Bone

Reis

Ramos

2021

Front. Bioeng. Biotechnol.

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Oxidative stress plays a central role in physiological and pathological bone conditions. Its role in signalment and control of bone cell population differentiation, activity, and fate is increasingly recognized. The possibilities of its use and manipulation with therapeutic goals are virtually unending. However, how redox balance interplays with the response to mechanical stimuli is yet to be fully understood. The present work summarizes current knowledge on these aspects, in an integrative and broad introductory perspective.

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“…As mentioned above, one of the mechanisms responsible for the reduction in blood TG levels is the increased expression of mRNA encoding the PGC-1α protein [76,78,79]. In a recent study [82], the authors found that higher training intensity contributes to higher PGC-1α gene expression. We suspect that higher training intensity or a higher hypoxic stimulus may lead to an improvement in the lipid profile after IHT training.…”

Section: Discussionmentioning

confidence: 95%

Exposure to Normobaric Hypoxia Combined with a Mixed Diet Contributes to Improvement in Lipid Profile in Trained Cyclists

et al. 2021

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This study aimed to analyze the effects of live high-train low method (LH-TL) and intermittent hypoxic training (IHT) with a controlled mixed diet on lipid profile in cyclists. Thirty trained male cyclists at a national level with at least six years of training experience participated in the study. The LH-TL group was exposed to hypoxia (FiO2 = 16.5%) for 11–12 h a day and trained under normoxia for 3 weeks. In the IHT group, participants followed the IHT routine three times a week under hypoxia (FiO2 = 16.5%) at lactate threshold intensity. The control group (N) lived and trained under normoxia. The results showed that the 3-week LH-TL method significantly improved all lipid profile variables. The LH-TL group showed a significant increase in HDL-C by 9.0% and a decrease in total cholesterol (TC) by 9.2%, LDL-C by 18.2%, and triglycerides (TG) by 27.6%. There were no significant changes in lipid profiles in the IHT and N groups. ∆TG and ∆TC were significantly higher in the LH-TL group compared to the N group. In conclusion, hypoxic conditions combined with a mixed diet can induce beneficial changes in lipid profile even in highly trained athletes. The effectiveness of the hypoxic stimulus is closely related to the hypoxic training method.

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The effects of different training modalities on monocarboxylate transporters MCT1 and MCT4, hypoxia inducible factor-1α (HIF-1α), and PGC-1α gene expression in rat skeletal muscles

Cited by 9 publications

References 46 publications

Physical Performance and Skeletal Muscle Transcriptional Adaptations Are Not Impacted by Exercise Training Frequency in Mice with Lower Extremity Peripheral Artery Disease

Physical Performance and Skeletal Muscle Transcriptional Adaptations Are Not Impacted by Exercise Training Frequency in Mice with Lower Extremity Peripheral Artery Disease

In Sickness and in Health: The Oxygen Reactive Species and the Bone

Exposure to Normobaric Hypoxia Combined with a Mixed Diet Contributes to Improvement in Lipid Profile in Trained Cyclists

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