The effects of diphenyl diselenide on oxidative stress biomarkers in Cyprinus carpio exposed to herbicide quinclorac (Facet®)

Menezes, Charlene; Leitemperger, Jossiele; Santi, Adriana; Lópes, Thais; Veiverberg, Cátia Aline; Peixoto, Sandra Cadore; Adaime, Martha B.; Zanella, Renato; Barbosa, Nilda Vargas; Loro, Vânia Lúcia

doi:10.1016/j.ecoenv.2012.04.022

Cited by 32 publications

(18 citation statements)

References 29 publications

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“…In some studies, hepatic GST activity decreased after 5 days of exposure to a mixture of pesticides (36). Similarly, liver of fish fed with a standard diet and exposed to the herbicide quinclorac showed a marked inhibition of GST activity (2). Nevertheless, some studies have also observed an opposite effect, as for example low level exposure of Galaxias maculatus, Galaxias truttaceus, and Salmo gairdneri to the fungicide tetrachloroisophthalonitrile resulted with the induction of the liver GST activity (37).…”

Section: Figure 1 Levels Of Catalase (Cat) Glutathione-s-transferasementioning

confidence: 92%

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Different Enzymatic Activities in Carp (Cyprinus Carpio L.) as Potential Biomarkers of Exposure to the Pesticide Methomyl

Hernández‐Moreno

Resino

Flores

et al. 2014

Archives of Industrial Hygiene and Toxicology

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This study investigated the influence of the pesticide methomyl on different enzymatic activities in carp. The fish were exposed to a sub-lethal concentration (0.34 mg L -1 ) of methomyl for 15 days. On days 4 and 15, catalase (CAT) and glutathione-S-transferase (GST) activities were measured in the liver and gills. Acetylcholinesterase (AChE) activity in brain and muscle was also determined. Liver catalase activity slightly increased in exposed fish when compared to controls, but it was statistically significant only at the beginning of the experiment. No changes in CAT activity in the gills of exposed and control animals were observed (mean values were in the range 10.7-11.7 nmol min -1 per mg of protein). Liver GST activity was slightly inhibited in the exposed animals at the beginning of the study; however, it was significantly inhibited in the gills. Brain AChE activity was diminished throughout the experiment and significantly decreased after 96 h of exposure compared to controls (0.041 vs. 0.075 nmol min -1 per mg of protein; p<0.001). Our findings suggest that CAT, GST, and AChE are reliable biomarkers of effect after exposure to methomyl.

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Section: Figure 1 Levels Of Catalase (Cat) Glutathione-s-transferasementioning

confidence: 92%

“…Carp is often recommended for the baseline evaluation of emerging pollutants in aquatic ecosystems (1) and commonly used in experimental models due to its availability and good adaptation to laboratory conditions (2).…”

mentioning

confidence: 99%

Different Enzymatic Activities in Carp (Cyprinus Carpio L.) as Potential Biomarkers of Exposure to the Pesticide Methomyl

Hernández‐Moreno

Resino

Flores

et al. 2014

Archives of Industrial Hygiene and Toxicology

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“…Contrastingly, Se compounds are also able to protect fish from the toxicity of pesticides [5] – [7] . Organic forms of Se have been suggested as relevant biologic antioxidant agents in different experimental models [4] , [6] . Diphenyl diselenide is an organoselenium compound and the simplest of the diaryl diselenides that has numerous pharmacological properties such as anti-inflammatory, antinociceptive, neuroprotective and antioxidant [3] , [6] , [8] .…”

Section: Introductionmentioning

confidence: 99%

“…Organic forms of Se have been suggested as relevant biologic antioxidant agents in different experimental models [4] , [6] . Diphenyl diselenide is an organoselenium compound and the simplest of the diaryl diselenides that has numerous pharmacological properties such as anti-inflammatory, antinociceptive, neuroprotective and antioxidant [3] , [6] , [8] . This compound has been used in fish diet to attempt reduce and/or attenuate the impacts of herbicides [6] , [7] .…”

Section: Introductionmentioning

confidence: 99%

“…The toxic effects of herbicides are mediated by reactive oxygen species (ROS) which can react with biological molecules and initiate oxidative damage including lipid peroxidation, protein oxidation and metabolic and enzymatic changes. Our group has already demonstrated that quinclorac exposure produces changes in the metabolic state, induces oxidative damage and reduces antioxidant status in tissues of Leporinus obtusidens and Cyprinus carpio [6] , [11] . Each metabolic pathway is regulated continuously within cells in order to maintain homeostasis in the organism.…”

Section: Introductionmentioning

confidence: 99%

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Diet with Diphenyl Diselenide Mitigates Quinclorac Toxicity in Silver Catfish (Rhamdia quelen)

et al. 2014

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In this study, the protective effects of diphenyl diselenide [(PhSe)2] on quinclorac- induced toxicity were investigated in silver catfish (Rhamdia quelen). The fish were fed for 60 days with a diet in the absence or in the presence of 3.0 mg/Kg (PhSe)2. Animals were further exposed to 1 mg/L quinclorac for 8 days. At the end of experimental period, fish were euthanized and biopsies from liver and gills, as well as blood samples, were collected. The cortisol and metabolic parameters were determined in plasma, and those enzyme activities related to osmoregulation were assayed in the gills. In liver, some important enzyme activities of the intermediary metabolism and oxidative stress-related parameters, such as thiobarbituric acid-reactive substance (TBARS), protein carbonyl, catalase (CAT), superoxide dismutase (SOD), glutathione S-transferase (GST), nonprotein thiols (NPSH) and ascorbic acid contents were also evaluated. Compared to the control group, quinclorac exposure significantly decreased hepatosomatic index and increased cortisol and lactate values in plasma. Moreover, the activities of fructose biphosphatase (FBPase), glucose-6-phosphate dehydrogenase (G6Pase), glycogen phosphorilase (GPase) and aspartate aminotransferase (AST) were significantly increased in liver. Quinclorac also induced lipid peroxidation while the activity of SOD, NPSH and ascorbic acid levels decreased in the liver. However, dietary (PhSe)2 reduced the herbicide-induced effects on the studied parameters. In conclusion, (PhSe)2 has beneficial properties based on its ability to attenuate toxicity induced by quinclorac by regulating energy metabolism and oxidative stress-related parameters.

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Toxicology and pharmacology of synthetic organoselenium compounds: an update

2021

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Here, we addressed the pharmacology and toxicology of synthetic organoselenium compounds and some naturally occurring organoselenium amino acids. The use of selenium as a tool in organic synthesis and as a pharmacological agent goes back to the middle of the nineteenth and the beginning of the twentieth centuries. The rediscovery of ebselen and its investigation in clinical trials have motivated the search for new organoselenium molecules with pharmacological properties. Although ebselen and diselenides have some overlapping pharmacological properties, their molecular targets are not identical. However, they have similar anti-inflammatory and antioxidant activities, possibly, via activation of transcription factors, regulating the expression of antioxidant genes. In short, our knowledge about the pharmacological properties of simple organoselenium compounds is still elusive. However, contrary to our early expectations that they could imitate selenoproteins, organoselenium compounds seem to have non-specific modulatory activation of antioxidant pathways and specific inhibitory effects in some thiol-containing proteins. The thiol-oxidizing properties of organoselenium compounds are considered the molecular basis of their chronic toxicity; however, the acute use of organoselenium compounds as inhibitors of specific thiol-containing enzymes can be of therapeutic significance. In summary, the outcomes of the clinical trials of ebselen as a mimetic of lithium or as an inhibitor of SARS-CoV-2 proteases will be important to the field of organoselenium synthesis. The development of computational techniques that could predict rational modifications in the structure of organoselenium compounds to increase their specificity is required to construct a library of thiol-modifying agents with selectivity toward specific target proteins.

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The effects of diphenyl diselenide on oxidative stress biomarkers in Cyprinus carpio exposed to herbicide quinclorac (Facet®)

Cited by 32 publications

References 29 publications

Different Enzymatic Activities in Carp (Cyprinus Carpio L.) as Potential Biomarkers of Exposure to the Pesticide Methomyl

Different Enzymatic Activities in Carp (Cyprinus Carpio L.) as Potential Biomarkers of Exposure to the Pesticide Methomyl

Diet with Diphenyl Diselenide Mitigates Quinclorac Toxicity in Silver Catfish (Rhamdia quelen)

Toxicology and pharmacology of synthetic organoselenium compounds: an update

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