The Effects of Enalapril and Irbesartan in Experimental Diabetic Nephropathy

Yalçın, Ömer; Üstündağ, Sedat; Sen, Sayan; Usta, Ufuk; Hüseyinova, Gülara; Puyan, Fulya Öz; Kutlu, Kemal; Tudan, M.

doi:10.1080/13102818.2007.10817475

Cited by 3 publications

(3 citation statements)

References 26 publications

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“…The STZ was administered intraperitoneally at doses of 50 mg/kg to induce a permanent and severe diabetic state. At 72 h after STZ injection, blood samples were obtained to confirm severe diabetic levels, and rats that presented blood glucose levels superior to 300 mg/dL were included in the short-term severe diabetic groups ( 19 ).…”

Section: Methodsmentioning

confidence: 99%

Morphological changes in rat rectus abdominis muscle induced by diabetes and pregnancy

Vesentini

Marini

Pículo

et al. 2018

Braz J Med Biol Res

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The urethral muscle of diabetic pregnant rats is affected by long-term mild diabetes and short-term severe diabetes, which plays a crucial role in the pathogenesis of pelvic floor disorders. We hypothesized that muscles outside the pelvis are subject to similar changes. The current study aimed at analyzing the effects of long-term mild and short-term severe diabetes on the structure and ultrastructure of fiber muscles and collagen in rats' rectus abdominis (RA) muscle. Therefore, the RA muscle of virgin, pregnant, long-term mild diabetic, short-term severe diabetic, long-term mild diabetic pregnant and short-term severe diabetic pregnant 3-month-old Wistar rats were collected. The structure was analyzed by picrosirius red staining, immunohistochemistry for fast and slow muscle fibers and transmission electron microscopy. We investigated two levels of STZ- induced diabetes: long-term mild diabetes (blood glucose level: 120–200 mg/dL) and short-term severe diabetes (blood glucose level >300 mg/dL). Long-term mild diabetic pregnant and short-term severe diabetic pregnant rats had decreased fast fibers and increased slow fibers, disrupted areas of sarcomere, intermyofibrillar mitochondria and myelin figures in the RA muscle. Both groups enabled us to analyze the specific influence of pregnancy, separately from diabetes. The current study demonstrated that diabetes and pregnancy induced intramuscular transformation and reorganization of RA muscle with a switch of fiber type adjusting their architecture according to intensity and duration of hyperglycemic insult within pregnancy.

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Section: Methodsmentioning

confidence: 99%

Morphological changes in rat rectus abdominis muscle induced by diabetes and pregnancy

Vesentini

Marini

Pículo

et al. 2018

Braz J Med Biol Res

View full text Add to dashboard Cite

show abstract

“…Severe diabetes was induced in adult female rats (90 days of age) by a single intraperitoneal injection of STZ (Sigma Chemical Company, St. Louis, Millstone, USA), at a dose of 50 mg/kg (0.1 M, pH 4.5) . Mild diabetes was induced in newborn female rats by STZ (100 mg/kg) subcutaneously injected at birth .…”

Section: Methodsmentioning

confidence: 99%

“…The preimplantation loss rate was calculated by the following formula: number of corpora lutea − number of implantations × 100/number of corpora lutea. The postimplantation loss rate was calculated by the following formula: number of implantations − number of living fetuses × 100/number of implantations .…”

Section: Methodsmentioning

confidence: 99%