The effects of erythromycin towards the treatment of persistent rhinosinusitis after functional endoscopic sinus surgery

Wu, Shang‐Heng; Hsu, Shuo–Hsiu; Liang, Kai‐Li; Jiang, Rong–San

doi:10.1097/jcma.0000000000000041

Cited by 7 publications

(24 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…9 Functional endoscopic sinus surgery (FESS) has become a standard modality for treating patients with CRS whose prior medical treatment has failed, and good success rates have been reported. 12 In this study, we used solution-based whole-mouth as well as regional tongue taste tests to investigate the effect of FESS on the taste function of patients with CRS.…”

Section: Introductionmentioning

confidence: 99%

Effect of Functional Endoscopic Sinus Surgery on Gustatory Function in Patients With Chronic Rhinosinusitis

2021

Self Cite

View full text Add to dashboard Cite

Objectives: In this study, we investigated the effect of functional endoscopic sinus surgery (FESS) on gustatory function in patients with chronic rhinosinusitis (CRS). Methods: Forty-three patients with CRS who underwent FESS were included in this study. Prior to FESS and 3 months after surgery, the severity of rhinosinusitis was assessed using the Taiwanese version of the 22-item SNOT (SNOT-22), endoscopic examination, and acoustic rhinometry. The olfactory function was evaluated using the phenylethyl alcohol odor detection threshold test and the traditional Chinese version of the University of Pennsylvania Smell Identification Test, and the gustatory function was evaluated using the whole mouth suprathreshold taste test (WMTT) and the taste quad test (TQT). Subgroup analyses were performed based on CRS phenotypes and endotypes. Results: The SNOT-22 significantly improved 3 months after FESS for all patients with CRS. The endoscopic score and olfactory function significantly improved in patients with eosinophilic CRS and in patients with nasal polyps (CRSwNP). The WMTT sweet and bitter scores were significantly lower after FESS in CRSwNP, but the TQT sweet score was significantly higher in patients without nasal polyps. In addition, patients with noneosinophilic CRS had significantly decreased WMTT and salty scores 3 months after FESS. Conclusion: Our results showed that the effect of FESS on gustatory function of patients with CRS was different with the different testing procedures, the association with nasal polyps, and the underlying inflammatory patterns.

show abstract

Section: Introductionmentioning

confidence: 99%

Effect of Functional Endoscopic Sinus Surgery on Gustatory Function in Patients With Chronic Rhinosinusitis

2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…The specific research characteristics and details are shown in Table 1. Among these studies, 3 of them limited patients' phenotype to CRSwNP, 25,27,34 while the remaining 5 studies did not set limits regarding the phenotype of CRS 20,21,24,26,35 . Referring to previous research practice, 36 studies on CRS that included mixed populations without phenotype limitation were classified as CRSsNP 20,24 or CRSwNP, 21,26,35 according to which group of patients accounted for more than 50% of the total.…”

Section: Resultsmentioning

confidence: 99%

Systematic Review and Meta‐analysis: Macrolide in the Treatment of Chronic Rhinosinusitis After Endoscopic Sinus Surgery

Shu,

Li,

Zhang

et al. 2023

Otolaryngol.--head neck surg.

View full text Add to dashboard Cite

ObjectivesTo evaluate the efficacy and safety of macrolide antibiotics therapy in patients with chronic rhinosinusitis (CRS) receiving endoscopic sinus surgery.Data SourcesPubMed, Web of Science, Embase, and Cochrane Library.Review MethodsThe electronic databases were comprehensively searched on June 2, 2022, for randomized controlled trials on macrolide antibiotics in the treatment of patients undergoing CRS endoscopic surgery. The primary outcome measures were the sinonasal outcome test (SNOT) score and the visual analog scale (VAS) score. The secondary outcome measures were the nasal endoscopy score (NES), the sinus computed tomography score, and adverse events.ResultsA total of 8 studies were included, involving 606 patients who used macrolide for a long time. Meta‐analysis showed that no significant difference was observed in SNOT (standardized mean difference [SMD] = −0.13; 95% confidence interval [CI]: −0.38 to 0.13, I2 = 0%) and VAS (SMD = −0.10; 95% CI, −0.88 to 0.68, I2 = 81%) between the macrolide and placebo groups. However, macrolide outperformed the placebo in improving NES (SMD = −0.32; 95% CI, −0.62 to −0.03, I2 = 21%). The use of macrolide did not increase the incidence of adverse events.ConclusionLong‐term use of macrolide after CRS surgery may not significantly improve the quality of life and disease severity of the patients but may play a role in improving postoperative NES in patients with CRS. There is still no sufficient evidence to determine whether the disease phenotype of CRS or the patient's race will affect the efficacy of long‐term use of macrolide after CRS.

show abstract

“…We had conducted a study comparing the effects of intranasal steroid or EM towards rhinosinusitis patients 33 . Results of aforementioned study demonstrated that the improvement in mucociliary function was higher in the EM group than in the intranasal steroid group.…”

Section: Discussionmentioning

confidence: 99%

Erythromycin reduces nasal inflammation by inhibiting immunoglobulin production, attenuating mucus secretion, and modulating cytokine expression

Yen

Jiang

Chang

et al. 2021

Sci Rep

Self Cite

View full text Add to dashboard Cite

Allergic rhinitis (AR) and chronic rhinosinusitis (CRS) share some similar pathological mechanisms. In current study, we intend to investigate the impact of AR on CRS. In addition, we explored the efficacy of erythromycin (EM) treatment on CRS mice with or without AR (CRSwoAR, CRSwAR). Study subjects were divided into control, CRSwoAR, and CRSwAR groups. Experimental mice were divided similarly into control, CRSwoAR, and CRSwAR groups. In addition, CRS mice were treated with EM at 0.75, 7.5, or 75 mg/kg or with dexamethasone (Dex) at 1 mg/kg. In our results, allergy exacerbates inflammation that was evident in nasal histology and cytokine expression both in patients and in mice with CRS. Dex 1 mg/kg, EM 7.5 or 75 mg/kg treatments significantly inhibited serum IgE and IgG2a in CRS mice. EM-treated CRS mice had significantly elevated IL-10 levels and had a reversal of Th-1/Th-2 cytokine expression in nasal-associated lymphoid tissue. MUC5AC expressions were significantly reduced in the 7.5 or 75 mg/kg EM-treated mice compared with untreated mice. EM showed inhibitions on immunoglobulin production and mucus secretion stronger than Dex. We concluded that comorbid AR enhanced inflammation of CRS. EM and Dex treatments showed similar anti-inflammatory effects on CRS but through partly different mechanisms.

show abstract

The effects of erythromycin towards the treatment of persistent rhinosinusitis after functional endoscopic sinus surgery

Cited by 7 publications

References 18 publications

Effect of Functional Endoscopic Sinus Surgery on Gustatory Function in Patients With Chronic Rhinosinusitis

Effect of Functional Endoscopic Sinus Surgery on Gustatory Function in Patients With Chronic Rhinosinusitis

Systematic Review and Meta‐analysis: Macrolide in the Treatment of Chronic Rhinosinusitis After Endoscopic Sinus Surgery

Erythromycin reduces nasal inflammation by inhibiting immunoglobulin production, attenuating mucus secretion, and modulating cytokine expression

Contact Info

Product

Resources

About