The effects of exogenous prostaglandins on orthodontic tooth movement in rats

Leiker, Bradley J.; Nanda, Ram S.; Currier, G. Fräns; Howes, Ruth; Sinha, Pramod K.

doi:10.1016/s0889-5406(95)70035-8

Cited by 139 publications

(106 citation statements)

References 14 publications

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“…In contrast to orthopedic studies, which typically show anabolic effects of PGE2 (Norrdin, Jee & High, 1990), studies have reported increase in bone resorption alone (Boekenoogen et al, 1996;Chao et al, 1988;Kale et al, 2004;Leiker et al, 1995;Seifi et al, 2003;Yamasaki, Shibata & Fukuhara, 1982). For ERR, there are studies that report an increase (Boekenoogen et al, 1996;Leiker et al, 1995), but there are also studies that report no significant effect of this molecule (Brudvik & Rygh, 1991). The controversies regarding bone formation, resorption and ERR may be related to differences in the methods of these studies, including dosage of PGE2 and previously discussed limitations of histological methods.…”

Section: Biological Factors In Rate Of Tooth Movement and Errmentioning

confidence: 98%

“…In bone biology, lower dosages of PGE2 were shown to have anabolic effects, whereas higher dosages appear to disrupt this effect and cause bone resorptionthis effect appears to be linked to a consequential increase in IGF-1 levels (Baylink, Finkelman & Mohan, 1993). In orthodontics, there seems to be a consensus on the fact that PGE2 injections increase the rate of tooth movement (Bao, Zhao & Rao, 1995;Chao et al, 1988;Kale et al, 2004;Kokkinos et al, 1993;Leiker et al, 1995;Seifi, Eslami & Saffar, 2003). In contrast to orthopedic studies, which typically show anabolic effects of PGE2 (Norrdin, Jee & High, 1990), studies have reported increase in bone resorption alone (Boekenoogen et al, 1996;Chao et al, 1988;Kale et al, 2004;Leiker et al, 1995;Seifi et al, 2003;Yamasaki, Shibata & Fukuhara, 1982).…”

Section: Biological Factors In Rate Of Tooth Movement and Errmentioning

confidence: 99%

“…In orthodontics, there seems to be a consensus on the fact that PGE2 injections increase the rate of tooth movement (Bao, Zhao & Rao, 1995;Chao et al, 1988;Kale et al, 2004;Kokkinos et al, 1993;Leiker et al, 1995;Seifi, Eslami & Saffar, 2003). In contrast to orthopedic studies, which typically show anabolic effects of PGE2 (Norrdin, Jee & High, 1990), studies have reported increase in bone resorption alone (Boekenoogen et al, 1996;Chao et al, 1988;Kale et al, 2004;Leiker et al, 1995;Seifi et al, 2003;Yamasaki, Shibata & Fukuhara, 1982). For ERR, there are studies that report an increase (Boekenoogen et al, 1996;Leiker et al, 1995), but there are also studies that report no significant effect of this molecule (Brudvik & Rygh, 1991).…”

Section: Biological Factors In Rate Of Tooth Movement and Errmentioning

confidence: 99%

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Orthodontic mechanotransduction and the role of the P2X7 receptor

Viecilli

Katona

Chen

et al. 2009

American Journal of Orthodontics and Dentofacial Orthopedics

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DEDICATIONTo my parents, who have supported my education. iv ACKNOWLEDGMENTSOne of the most important things I have learned during my PhD is the necessity of the existence of a working network of people that can help you achieve your goals. The more effectively this network functions, the higher the chance you will achieve the goals quickly.I would first like to thank my parents, who have unconditionally supported my decision to abandon a profitable private practice in Orthodontics, and return to humble student conditions while aiming for a full time academic career.I also thank my girlfriend Laura Kruter who has (almost always) been ok with my, some might say, not very sane ideas. Sometimes they do turn out fine, though (like this "PhD" one).I can hardly think of anyone else that could have complemented my work and ideas during this Program as well as Dr. Thomas Katona. While I was passionately conditioned to an idea, he was always rational and careful. While I was sometimes furious with a shortcoming, he was always temperate and humorous. When I ran into his office with some news about a project, he would always listen and almost never seem too busy to see me. While I was working and something went wrong, he would listen and wonder with me about the "whys" and "hows", instead of telling me what to do or express disappointment. He was even subject to some of my home culinary experiments. I was extremely fortunate to find someone that thought about science the same way I did, and that actually helped me with my project instead of just telling me what to do. I felt like we worked as a team, and that helped to increase my motivation during my studies. The third part of this project tested the role of the P2X7 receptor in the dentoalveolar morphology of C57B/6 mice. P2X7R KO (knockout) mice were compared to C57B/6 WT to identify differences in a maxillary molar and bone. Tooth dimensions viii were measured and 3D bone morphometry was conducted. No statistically significant differences were found between the two mouse types. P2X7R does not have a major effect on alveolar bone or tooth morphology.The final part examines the role of the P2X7 receptor in a controlled biomechanical model. Orthodontic mechanotransduction was compared in wild-type (WT) and P2X7R knock-out (KO) mice. Using Finite Element Analysis, mouse mechanics were scaled to produce typical human stress levels. Relationships between the biological responses and the calculated stresses were statistically tested and compared.There were direct relationships between certain stress magnitudes and root resorption and bone formation. Hyalinization and root and bone resorption were different in WT and KO. Orthodontic responses are related to the principal stress patterns in the PDL and the P2X7 receptor plays a significant role in their mechanotransduction.

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Section: Biological Factors In Rate Of Tooth Movement and Errmentioning

confidence: 98%

Section: Biological Factors In Rate Of Tooth Movement and Errmentioning

confidence: 99%

Section: Biological Factors In Rate Of Tooth Movement and Errmentioning

confidence: 99%

See 1 more Smart Citation

Orthodontic mechanotransduction and the role of the P2X7 receptor

Viecilli

Katona

Chen

et al. 2009

American Journal of Orthodontics and Dentofacial Orthopedics

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“…Methods such as local/systemic pharmaceutical administration as well as physical and mechanical stimulation have been reported to accelerate tooth movement. 1,2 However, these methods might not be applicable to daily clinical practice because of their side effects and because their outcomes await validation. [3][4][5] Over the past decade, the regional acceleratory phenomenon (RAP) induced by surgical trauma has received considerable emphasis for reducing the treatment time.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the effects of micro-osteoperforation and corticision on the rate of orthodontic tooth movement in rats

Tsai

Yang

Hsieh

et al. 2015

The Angle Orthodontist

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Objective: To investigate the effects of flapless micro-osteoperforation and corticision on the rate of orthodontic tooth movement in rats. Materials and Methods: Forty-five 8-week-old male Sprague-Dawley rats were divided into the following groups: micro-osteoperforation and orthodontic force (MOP + F), corticision and orthodontic force (C + F), and orthodontic force only (F, control). The left maxillary first molars were pulled forward with a force of 50 g. Flapless surgical interventions were conducted in the MOP + F and C + F groups. The total duration of the experiment was 6 weeks. Alveolar bone density and the number of osteoclasts were evaluated using microcomputed tomography and histologic examination, respectively. Results: The tooth movement distance was significantly higher in both experimental groups than in the control group. Bone density and bone mineral density decreased in the MOP + F and C + F groups. The number of osteoclasts in the MOP + F and C + F groups was significantly higher than in the control group F. Conclusion: The two minimally invasive flapless surgical interventions increased bone remodeling and osteoclast activity and induced faster orthodontic tooth movement for at least 2 weeks in rats. No differences were observed between the outcome of flapless micro-osteoperforation and corticision in the rats. (Angle Orthod. 2016;86:558-564.)

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“…Utilisation d'agents pharmacologiques P.A. : Vous avez dirigé plusieurs recherches histologiques [5,30,37,41,44,56], consacrées au déplacement dentaire et à sa modulation par l'utilisation d'agents pharmacologiques. Quelle est l'incidence de ces agents sur le mouvement dentaire et le risque de résorption radiculaire ?…”

Section: Thérapie Laser De Faible Intensitéunclassified

Une orthodontie contemporaine fondée sur l'harmonie esthétique et sur la biomécanique. Un entretien avec Ravindra Nanda

Nanda

Amat

2017

Orthod Fr

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Le Pr Ravindra Nanda a obtenu une licence et une maîtrise en dentisterie et en orthodontie du King George's Medical College, Lucknow University. En 1967, il a intégré l'Université Catholique de Nimègue, aux Pays-Bas, où il a obtenu un doctorat en philosophie en 1969. Il a rejoint la nouvelle école dentaire de Loyola à Chicago en 1970, après avoir occupé le poste de Professeur assistant en orthodontie dans le service dirigé par Frans van der Linden. En 1972, il fut promu au Département d'Orthodontie de l'Université du Connecticut à Farmington, CT, et y reçu son certificat en orthodontie sous la direction de Charles Burstone. Professeur adjoint, puis professeur titulaire à partir de 1979, il a assumé le poste de Chef du Département d'Orthodontie à partir de 1992 et a été promu pour diriger le Département des Sciences Craniofaciales en 2004, dont les divisions de chirurgie orale et maxillo-faciale, de dentisterie pédiatrique, de l'enseignement supérieur en dentisterie générale et en orthodontie. Il est membre et ancien président de la composante Atlantique Nord de la Edward H. Angle Society of Orthodontists. Il occupe actuellement la fonction de rédacteur en chef de Progress in Orthodontics, de rédacteur associé du Journal of Clinical Orthodontics et est membre du comité éditorial de neuf revues d'orthodontie nationales et internationales. Il est membre de l'Association dentaire américaine, de l'Association dentaire de l'État du Connecticut, de la Hartford Dental Society, de l'Association américaine des orthodontistes, de la Société européenne d'orthodontie, de l'Association internationale de recherche dentaire et du College of Diplomates of American Board of Orthodontists. Il a rédigé et publié sept manuels et plus de 200 articles dans des revues à comité de lecture. Il a donné des conférences magistrales dans plus de 40 pays et a reçu de nombreux prix et honneurs pour ses contributions en dentisterie et en orthodontie, aux États-Unis et de la part d'organisations internationales d'orthodontie. Il est membre d'honneur des Jordan Orthodontic Society, Czech Orthodontic Society, Taiwanese Orthodontic Society, Central American Orthodontics Society et membre d'honneur à vie de l'Indian Orthodontic Society. Ravindra Nanda a été honoré du Life Time Achievement Award (University of Connecticut Foundation), et il est Senior Research Fellow (Japan Promotion for Science, Sendai, Japan − Tohoku University). Il a prononcé de nombreuses conférences d'honneur : la John Taylor Lecture, lors de la réunion annuelle de l'Australian Society of Orthodontics Foundation, la Sheldon Friel Memorial Lecture lors de la réunion annuelle de l'European Orthodontic Society, la Gordon Kirkness Memorial Lecture lors de la réunion annuelle de l'Australian Society of Orthodontics, la John Mershon Memorial Lecture, Boston, Massachusetts lors de la réunion annuelle de l'American Association of Orthodontics et la Wendell L. Wylie Memorial Lecture, à l'Université de San Francisco, Californie.

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The effects of exogenous prostaglandins on orthodontic tooth movement in rats

Cited by 139 publications

References 14 publications

Orthodontic mechanotransduction and the role of the P2X7 receptor

Orthodontic mechanotransduction and the role of the P2X7 receptor

Comparison of the effects of micro-osteoperforation and corticision on the rate of orthodontic tooth movement in rats

Une orthodontie contemporaine fondée sur l'harmonie esthétique et sur la biomécanique. Un entretien avec Ravindra Nanda

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