Comparison of the effects of micro-osteoperforation and corticision on the rate of orthodontic tooth movement in rats

Tsai, Chi-Yang; Yang, Teng-Kai; Hsieh, Hsueh-Yin; Yang, Liang-Yu

doi:10.2319/052015-343.1

Cited by 72 publications

(49 citation statements)

References 15 publications

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“…Tsai et al recently reported that MOP-facilitated ATM resulted in decreased root resorption upon H&E analysis. 40 Similarly, while half of the H&E samples in our study showed moderate root resorption on the MOP side, our volumetric analysis of all five roots of the maxillary first molar showed no significant increase in root resorption with MOPs, suggesting that MI-faciliated MOPs induced ATM without causing significant adverse effects on roots. A larger sample size however, is needed to further validate this finding.…”

Section: Discussionmentioning

confidence: 41%

Ability of mini-implant–facilitated micro-osteoperforations to accelerate tooth movement in rats

Cheung

Park

Lee

et al. 2016

American Journal of Orthodontics and Dentofacial Orthopedics

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Introduction While current techniques for accelerated tooth movement (ATM) often involve invasive surgical procedures, micro-osteoperforations (MOPs) using mini-implants (MI) may facilitate orthodontic tooth movement without raising flaps, reducing surgical risks and increasing patient acceptance. In this study, we evaluated the effectiveness of MI-facilitated MOPs in inducing ATM and investigated potential risks for root resorption. Methods Five MOPs were placed on the left side around the maxillary first molars in six rats using an automated MI driver, while the right side received no MOPs as a control. Closed-coiled springs were secured from incisors to first molars for orthodontic tooth movement. Tooth movement was measured and samples underwent radiological and histological analyses. Results The MOP side exhibited a 1.86-fold increase in the rate of tooth movement with decreased bone density and decreased bone volume around first molars compared to the control. H&E and TRAP analysis showed increased numbers of osteoclasts as well as new bone formation. Three dimensional volumetric analysis of all five roots of maxillary first molars demonstrated no statistically significant difference in root volumes. Conclusions MI-facilitated MOPs accelerated tooth movement without increased risk for root resorption, and therefore may become a readily available and efficient treatment option to shorten orthodontic treatment time with improved patient acceptance.

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Section: Discussionmentioning

confidence: 41%

Ability of mini-implant–facilitated micro-osteoperforations to accelerate tooth movement in rats

Cheung

Park

Lee

et al. 2016

American Journal of Orthodontics and Dentofacial Orthopedics

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“…Among the surgery-assisted techniques, MOP is a new method to accelerate orthodontic tooth movement through small perforations in the alveolar bone without introducing great surgical trauma. The application of MOP in animal models has shown that small and shallow perforations in the alveolar bone increased the rate of tooth movement without requiring raising flaps, bone graft, or suture [23,24]. In comparison with the traditional orthodontics, a clinical study over a 1-month period has shown that when perforations are made to one side of the maxilla, the procedure significantly increased the rate of tooth movement by 2.3-fold, causing little pain or discomfort to the patients [2].…”

Section: Introductionmentioning

confidence: 99%

Effect of mini-screw-facilitated micro-osteoperforation on the rate of orthodontic tooth movement: a single-center, split-mouth, randomized, controlled trial

2020

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Objective: The present study aimed to evaluate the effect of MOP over a 3-month period and to determine the influence of the number of perforations on the rate of canine retraction. In addition, the amount of pain and discomfort caused by the MOP method was evaluated. Trial design: A single-center, split-mouth, triple-blind, randomized, controlled trial was conducted. Methods: The clinical trial was conducted from December 2018 to July 2019 in the Orthodontic Clinic, Shiraz Dental School. Twenty-eight patients (range from16.3 to 35.2 years) who need fixed orthodontic treatment were recruited and randomly assigned to MOP1 and MOP2 groups. In each patient one side of the mouth worked as a control side which received no MOPs. Four months after first premolars extraction, patients in MOP1 group received 3 MOPs on the buccal surface of alveolar bone in the experimental side to accelerate canine retraction whereas patients in MOP2 group received 3 buccal MOPs and 3 palatal MOPs in the experimental side. The amount of canine retraction was measured every 28 days at three intervals on both sides of the mouth. Pain perception was also measured on the day of MOP procedure and subsequently at 24 h. Randomization was performed using online software RANDOM.ORG; the recruited patients were divided into two parallel groups with a 1:1 allocation ratio then the side of MOPs intervention in each subject was randomly determined with coin tossing. Triple blinding design was employed. Results: The result of the intra-examiner reliability using ICC was 0.97 (P < 0.001), indicating excellent repeatability and reliability of the measurements. The baseline characteristics between the groups were similar (P > 0.05). There was a significant difference in the rate of canine retraction between the MOP groups and the contralateral control sides, as well as between the MOP1 and MOP2 groups (P < 0.05). Conclusion: The MOP procedure was effective in accelerating orthodontic tooth movement, although the amount of acceleration was not clinically significant in the case of canine retraction. An increase in the number of MOPs resulted in a significant acceleration of the canine retraction. Trial registration: The trial was registered 30 November 2018 at the Iranian Registry of Clinical Trials (IRCT20181121 041713N1).

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“…Cho et al 13 found that the amount of OTM increased to 4.41 times and 2.44 times in the maxilla and mandible, respectively, after applying 24 decortication dots with flap surgery in dogs. Tsai et al 14 found that the rate of OTM was 1.54 and 1.49 times as fast in a corticision group and micro-osteoperforation group, respectively, than in the control, showing no difference between the two flapless procedures. In the current study, it was found that flapless osteoperforation facilitated OTM by 1.81 times even through the atrophic ridge in the beagle mandible over 10 weeks.…”

Section: Discussionmentioning

confidence: 99%

Effect of flapless osteoperforation-assisted tooth movement on atrophic alveolar ridge: Histomorphometric and gene-enrichment analysis

Lee

Yul

Park

et al. 2017

The Angle Orthodontist

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Objective: To investigate the effect of flapless osteoperforation on the tissue response of the atrophic alveolar ridge affected by orthodontic tooth movement (OTM). Materials and Methods: An atrophic alveolar ridge model was established in the mandibular quadrants of eight beagle dogs. As a split-mouth design, the quadrants were randomly divided into group C (OTM only) and group OP (OTM with flapless osteoperforation). The rate of OTM for 10 weeks was compared between groups, and micro-CT-based histomorphometric analysis and RNAsequencing-based gene-enrichment analysis were performed targeting the atrophic ridge. Results: Group OP displayed more rapid tooth movement with lower bone mineral density and higher trabecular fraction in the atrophic ridge than did group C, showing no intergroup difference of total ridge volume. As contributing biological functional pathways in group OP, the genes related to osteoclast differentiation and TNF signaling pathway were up-regulated and those associated with Wnt signaling pathway and AMPK signaling pathway were down-regulated. Conclusions: Flapless osteoperforation facilitated the rate of OTM toward the atrophic ridge, maintaining low bone density, whereas it did not increase the volume of the atrophic ridge. (Angle Orthod. 2018;88:82-90.)

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Comparison of the effects of micro-osteoperforation and corticision on the rate of orthodontic tooth movement in rats

Cited by 72 publications

References 15 publications

Ability of mini-implant–facilitated micro-osteoperforations to accelerate tooth movement in rats

Ability of mini-implant–facilitated micro-osteoperforations to accelerate tooth movement in rats

Effect of mini-screw-facilitated micro-osteoperforation on the rate of orthodontic tooth movement: a single-center, split-mouth, randomized, controlled trial

Effect of flapless osteoperforation-assisted tooth movement on atrophic alveolar ridge: Histomorphometric and gene-enrichment analysis

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