The effects of extremely low frequency magnetic fields on mutation induction in mice

Wilson, James W.; Haines, Jackie; Sienkiewicz, Zenon; Dubrova, Yuri E.

doi:10.1016/j.mrfmmm.2015.01.014

Cited by 8 publications

(2 citation statements)

References 339 publications

(747 reference statements)

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“…The rate of spontaneous mutation at these loci is close to that for human mini satellites. In our studies, we have used ESTR loci for monitoring mutation induction in the germline of male mice exposed to ionizing radiation, chemical mutagens, anticancer drugs, and extremely low frequency magnetic fields [21,22,23,24,25,26,27,28,29]. The results of our studies highlight the key advantage of this technique that allows establishing the effects of exposure to mutagens within a very broad range of doses.…”

Section: Mutation Induction and Transgenerational Effectsmentioning

confidence: 99%

Mutation Induction in Humans and Mice: Where Are We Now?

Dubrova

2019

Cancers

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The analysis of mutation induction in human families exposed to mutagens provides the only source of reliable estimates of factors contributing to the genetic risk of human exposure to mutagens. In this paper, I briefly summarize the results of recent studies on the pattern of mutation induction in the human and mouse germline. The results of recent studies on the genome-wide effects of exposure to mutagens on mutation induction in the mammalian germline are presented and discussed. Lastly, this review also addresses the issue of transgenerational effects of parental exposure to mutagens on mutation rates in their non-exposed offspring, which are known as transgenerational instability. The possible contribution of transgenerational instability to the genetic risk of human exposure to mutagens is discussed.

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Section: Mutation Induction and Transgenerational Effectsmentioning

confidence: 99%

Mutation Induction in Humans and Mice: Where Are We Now?

Dubrova

2019

Cancers

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“…This method is used in studies on mutation induc tion in the mouse germline by radiation [51,[55][56][57][58][59][60][61][62][63], chemical mutagens and anticancer drugs [59,[64][65][66][67][68][69][70], nanoparticles [71], and changes in diet [72] and mag netic fields [73]. A detailed discussion of these studies is provided in several reviews [74,75].…”

Section: Mutation Induction In the Mouse Germlinementioning

confidence: 99%

Mutation induction in the mouse and human germline

Dubrova

2016

Russ J Genet

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The review describes the effects of exposure to mutagens on mutation induction in human and mouse germlines. The results of studies that evaluated inductions of mutations in human families subjected to irradiation are presented and discussed. The effects of exposure to mutagens on mutation induction in the mouse germline are also considered. We analyze and discuss the recent data on the genome wide effects of irradiation on mutation induction in the mouse germline obtained by next generation sequencing and com parative genome hybridization.

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