The Effects of Fibroblast Growth Factor-2 on Rotator Cuff Reconstruction With Acellular Dermal Matrix Grafts

Ide, Junji; Kikukawa, Kenshi; Hirose, Jun; Iyama, Ken Ichi; Sakamoto, Hidetoshi; Mizuta, Hiroshi

doi:10.1016/j.arthro.2008.11.011

Cited by 87 publications

(62 citation statements)

References 35 publications

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“…A burst release of 15.4% was detected during the initial 2 days, followed by a constant release for 14 days (days 2-16) and then a slow release for another 8 days (days [16][17][18][19][20][21][22][23][24]. bFGF located on or near the fiber surface results in the burst release, and the encapsulation of bFGF into the fiber core can apparently alleviate the initial burst release.…”

Section: In Vitro Bfgf Release Profilesmentioning

confidence: 94%

“…7 Considering the transient effect of bFGF delivery alone, Ide et al additionally implanted acellular dermal matrix scaffolds for RC repair in their later study. 17 These scaffolds produced a more delayed effect, with a significant increase in enthesis strength and tendon maturity at 6 and 12 weeks postoperatively. 17 However, these scaffolds, which are derived from dermis, appear to undergo remodeling slowly and may be incorporated by the host to some extent rather than replaced completely.…”

Section: Zhao Et Almentioning

confidence: 99%

“…17 These scaffolds produced a more delayed effect, with a significant increase in enthesis strength and tendon maturity at 6 and 12 weeks postoperatively. 17 However, these scaffolds, which are derived from dermis, appear to undergo remodeling slowly and may be incorporated by the host to some extent rather than replaced completely. 18 Additionally, a limited number of studies demonstrated meaningful improvement by combination therapies in chronic RCT models, which mostly reproduce the pathology seen in human RCTs.…”

Section: Zhao Et Almentioning

confidence: 99%

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Biological augmentation of rotator cuff repair using bFGF-loaded electrospun poly(lactide-co-glycolide) fibrous membranes

Zhao¹,

Zhao²,

Dong³

et al. 2014

IJN

108

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Clinically, rotator cuff tear (RCT) is among the most common shoulder pathologies. Despite significant advances in surgical techniques, the re-tear rate after rotator cuff (RC) repair remains high. Insufficient healing capacity is likely the main factor for reconstruction failure. This study reports on a basic fibroblast growth factor (bFGF)-loaded electrospun poly(lactide-co-glycolide) (PLGA) fibrous membrane for repairing RCT. Implantable biodegradable bFGF–PLGA fibrous membranes were successfully fabricated using emulsion electrospinning technology and then characterized and evaluated with in vitro and in vivo cell proliferation assays and repairs of rat chronic RCTs. Emulsion electrospinning fabricated ultrafine fibers with a core-sheath structure which secured the bioactivity of bFGF in a sustained manner for 3 weeks. Histological observations showed that electrospun fibrous membranes have excellent biocompatibility and biodegradability. At 2, 4, and 8 weeks after in vivo RCT repair surgery, electrospun fibrous membranes significantly increased the area of glycosaminoglycan staining at the tendon–bone interface compared with the control group, and bFGF–PLGA significantly improved collagen organization, as measured by birefringence under polarized light at the healing enthesis compared with the control and PLGA groups. Biomechanical testing showed that the electrospun fibrous membrane groups had a greater ultimate load-to-failure and stiffness than the control group at 4 and 8 weeks. The bFGF–PLGA membranes had the highest ultimate load-to-failure, stiffness, and stress of the healing enthesis, and their superiority compared to PLGA alone was significant. These results demonstrated that electrospun fibrous membranes aid in cell attachment and proliferation, as well as accelerating tendon–bone remodeling, and bFGF-loaded PLGA fibrous membranes have a more pronounced effect on tendon–bone healing. Therefore, augmentation using bFGF–PLGA electrospun fibrous membranes is a promising treatment for RCT.

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Section: In Vitro Bfgf Release Profilesmentioning

confidence: 94%

Section: Zhao Et Almentioning

confidence: 99%

Section: Zhao Et Almentioning

confidence: 99%

See 1 more Smart Citation

Biological augmentation of rotator cuff repair using bFGF-loaded electrospun poly(lactide-co-glycolide) fibrous membranes

Zhao¹,

Zhao²,

Dong³

et al. 2014

IJN

108

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“…These a broadly categorised to modalities to improve the repair site/tendon-to-bone healing environment and bridging techniques across large tears. Repair site augmentation options include gene therapy, stem cells, growth factors, transcription factors and platelet rich plasma (PRP) (65)(66)(67)(68)(69)(70)(71)(72)(73)(74). Studies into these options are still on-going with most results based on animal-research models.…”

Section: Biological Augmentationmentioning

confidence: 99%

Large/Massive Tears, Fatty Infiltration, and Rotator Cuff Muscle Atrophy: A Review Article With Management Options Specific to These Types of Cuff Deficiencies

et al. 2016

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Context: There are many studies in the literature looking into factors affecting outcomes in rotator cuff surgery. The aetiology of rotator cuff deficiency is often multi-factorial and there are many facets towards successful management in this often debilitating condition. Evidence Acquisition: We performed a literature search of MEDLINE and Embase databases using the terms large rotator cuff tears, fatty infiltration rotator cuff, rotator cuff atrophy, rotator cuff augmentation, rotator cuff tendon transfers, allografts rotator cuff repair, xenograft rotator cuff repair and synthetic grafts rotator cuff repair. Results: In this article, we focus particularly on the aetiology, pathology and prognosis of large tears, fatty infiltration and muscle atrophy of the rotator cuff. An overview of the various treatment strategies and current/future concepts are also discussed in managing patients with these types of rotator cuff deficiencies. Conclusions: Large tears, fatty infiltration and muscle atrophy of the cuff are challenging. An in-depth understanding of these elements may prove vital for the practising orthopedician in determining the right course of management. Techniques in strengthening the repair construct using augmentation play an important role in the treatment of this condition.

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“…In an effort to improve tendon-to-bone healing after rotator cuff repair, numerous biologic-and tissue engineering-based techniques have been used, including use of anabolic growth factors [23,25], proteinase inhibitors [3,4] as well as augmentation with stem and progenitor cell populations [19,21,33]. Mesenchymal stem cells (MSCs) are natively involved in tissue maturation, healing, and remodeling [43] and, as a result of their migratory, multipotent, and immunomodulatory properties, possess the potential for regenerating a wide range of pathologic or degenerative tissues.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Granulocyte-colony Stimulating Factor on Rotator Cuff Healing After Injury and Repair

Ross

Maerz

Kurdziel

et al. 2015

Clinical Orthopaedics &Amp; Related Research

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The Effects of Fibroblast Growth Factor-2 on Rotator Cuff Reconstruction With Acellular Dermal Matrix Grafts

Cited by 87 publications

References 35 publications

Biological augmentation of rotator cuff repair using bFGF-loaded electrospun poly(lactide-co-glycolide) fibrous membranes

Biological augmentation of rotator cuff repair using bFGF-loaded electrospun poly(lactide-co-glycolide) fibrous membranes

Large/Massive Tears, Fatty Infiltration, and Rotator Cuff Muscle Atrophy: A Review Article With Management Options Specific to These Types of Cuff Deficiencies

The Effect of Granulocyte-colony Stimulating Factor on Rotator Cuff Healing After Injury and Repair

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