The effects of five‐year growth hormone replacement therapy on muscle strength in elderly hypopituitary patients

Götherström, Galina; Bengtsson, Bengt‐Åke; Sunnerhagen, Katharina Stibrant; Johannsson, Gudmundur; Svensson, Johan

doi:10.1111/j.1365-2265.2004.02181.x

Cited by 40 publications

(46 citation statements)

References 47 publications

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“…After 10 years, BF was reduced, and LBM was increased, as measured using DEXA. This is consistent with the lipolytic and anabolic effects of GH observed in previous studies (4,10,23,24), demonstrating that a moderate dose of GH can induce a sustained improvement in body composition in elderly GHD adults. GH replacement, as previously shown (10,25), had a more marked effect on isometric knee flexor strength than on isokinetic knee flexor strength, possibly as a consequence of more reduced isometric strength in untreated GHD adults (9,26).…”

Section: Discussionsupporting

confidence: 79%

“…We demonstrated that GHD adults above 60 years of age had decreased age-and sex-adjusted muscle strength (4). The 5 years of GH replacement therapy normalized age-and sex-adjusted values of knee flexor strength, whereas knee extensor and handgrip strength were not fully normalized in the elderly GHD patients (4).…”

Section: Introductionmentioning

confidence: 99%

“…The 5 years of GH replacement therapy normalized age-and sex-adjusted values of knee flexor strength, whereas knee extensor and handgrip strength were not fully normalized in the elderly GHD patients (4). To date, the effects of prolonged (O5 years) GH replacement on muscle strength in elderly GHD adults are unknown.…”

Section: Introductionmentioning

confidence: 99%

“…Although elderly adults with GH deficiency (GHD) have significantly lower GH secretion than normal elderly subjects (1), both normal aging (2) and GHD (3,4) are associated with decreased muscle mass and strength. As GH plays an important role in maintaining of body composition, the progressive decline in GH secretion with increasing age may contribute to the age-related impairments in muscle mass and function (5).…”

Section: Introductionmentioning

confidence: 99%

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Muscle strength in elderly adults with GH deficiency after 10 years of GH replacement

Götherström¹,

Elbornsson²,

Sunnerhagen³

et al. 2010

European Journal of Endocrinology

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Context: Only few studies have investigated the effects of GH replacement on muscle strength in elderly patients with GH deficiency (GHD). Objective, design, and patients: In this prospective open-labeled study, the effects of 10 years of GH replacement on muscle strength and neuromuscular function were followed in 24 elderly GHD adults (mean age of 65.2 years; range 61-74 years). Muscle strength was compared with reference values obtained from the background population. Results: The mean initial GH dose of 0.72 mg/day was lowered to 0.37 mg/day. The mean IGF1 SDS increased from K1.10 at baseline to 1.17 at study end. GH replacement induced a sustained increase in lean body mass and a transient increase in isometric knee flexor strength. Isometric knee extensor strength was reduced after 10 years. However, after correction for age and gender, using observed/predicted value ratios, there was sustained and even progressive increase in most variables reflecting muscle strength. Measurements of neuromuscular function showed unchanged voluntary motor unit activation after 10 years. Conclusions: Ten years of GH replacement therapy in elderly GHD adults resulted in a transient increase in isometric knee flexor strength, and provided protection from most of the normal age-related decline in muscle performance and neuromuscular function.

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Section: Discussionsupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Muscle strength in elderly adults with GH deficiency after 10 years of GH replacement

Götherström¹,

Elbornsson²,

Sunnerhagen³

et al. 2010

European Journal of Endocrinology

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“…However, only eight different cohorts of patients were described in these 14 studies, because several studies described data from the same patient cohort. The studies by Götherström et al (12,19) and Toogood et al (20) (nZ12) also described the same patient cohort. Therefore, the data of these studies are described in combination.…”

Section: Resultsmentioning

confidence: 83%

GH replacement therapy in elderly GH-deficient patients: a systematic review

Kokshoorn

Biermasz

Roelfsema

et al. 2011

European Journal of Endocrinology

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Context: Recombinant human GH (rhGH) is prescribed for the treatment of adults with GH deficiency (GHD). However, conflicting data are available on the efficacy of rhGH treatment in elderly GHD patients. Objective: To assess the efficacy of rhGH treatment in elderly GHD subjects. Methods: We searched the available literature in PubMed, Cochrane Library, Web of Science and EMBASE. Study selection: Studies on GHD patients, aged O60 years, treated with rhGH were eligible for inclusion. Data extraction was performed by two reviewers independently. Results: We found 11 eligible studies with a total of 534 patients. Only two studies had prospective, randomized, placebo-controlled study designs of rhGH treatment with a duration of 6 (nZ15) and 12 months (nZ62), respectively. Treatment with rhGH decreased total and low density lipoprotein (LDL) cholesterol levels by 4-8 and 11-16%, respectively, but did not alter high density lipoprotein or triglyceride levels. RhGH did not affect body mass index, but decreased waist circumference (by w3 cm) and waist/hip ratio. RhGh did not consistently affect blood pressure or bone mineral density. RhGH increased lean body mass by 2-5% and decreased total fat mass by 7-10% in four studies, but did not affect body composition in two other studies. RhGH consistently improved quality of life (QoL) parameters reflected in AGHDA-scores. There were no explicit data on elderly GHD patients aged O80 years. Conclusion: RhGH replacement in elderly subjects with GHD decreases LDL cholesterol levels and improves QoL, but the effects on other parameters are not unequivocal. There were no data on the efficacy and safety of rhGH treatment in octogenarians with GHD.

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Endocrine Myopathies

Douglas

Hassan‐Smith

Ruff

2013

Neuromuscular Disorders in Clinical Practice

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The effects of five‐year growth hormone replacement therapy on muscle strength in elderly hypopituitary patients

Abstract: Elderly patients with adult onset GH deficiency had decreased baseline muscle strength also after correction for age and sex. The 5-year GH replacement therapy normalized knee flexor strength and improved, but did not fully normalize, knee extensor strength and handgrip strength.

Cited by 40 publications

References 47 publications

Muscle strength in elderly adults with GH deficiency after 10 years of GH replacement

Muscle strength in elderly adults with GH deficiency after 10 years of GH replacement

GH replacement therapy in elderly GH-deficient patients: a systematic review

Endocrine Myopathies

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