The effects of fluoride on cell migration, cell proliferation, and cell metabolism in GH4C1 pituitary tumour cells

Mendoza-Schulz, A.; Solano-Agama, Carmen; Arreola-Mendoza, Laura; Reyes-Márquez, Blanca E.; Barbier, Olivier; Razo, Luz M. Del; Mendoza-Garrido, M. Eugenia

doi:10.1016/j.toxlet.2009.07.014

Cited by 41 publications

(13 citation statements)

References 31 publications

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“…Fluorine is the most electronegative and reactive element, and it commonly forms salts as fluoride, such as sodium fluoride (NaF). Fluoride occurs naturally in the earth's crust and is the 13th most abundant element (Mendoza‐Schulz et al, ). The concentration of fluoride in uncontaminated freshwater's ecosystems ranges from 0.01 to 0.3 mg/L (Camargo, ; Rosso et al, ).…”

Section: Introductionmentioning

confidence: 99%

Effects of fluoride on morphology, growth, development, and thyroid hormone of Chinese toad (Bufo gargarizans) embryos

Zhang

Xie

Chai

et al. 2017

Environ and Mol Mutagen

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Excessive fluoride in natural water ecosystem has the potential to detrimentally affect amphibians, but little is known of such effects or underlying mechanisms in Bufo gargarizans embryos. In the present study, the effects of fluoride exposure on B. gargarizans embryos were investigated. First, fluoride teratogenic experiment showed that the 9 days EC of fluoride on B. gargarizans embryos was 177.62 mg/L. Then, we studied the sublethal effects of fluoride on B. gargarizans embryos at control, 0.7, 4.1, 19.6, 41.9, and 62.7 mg/L fluoride concentration. Malformation, growth, and development of embryos were monitored, and type 2 and 3 iodothyronine deiodinase (Dio2 and Dio3), thyroid hormone receptors (TRα and TRβ) mRNA levels were measured. Our results showed the morphological malformations, such as tail curvature (lordosis), edema, cuticularized ciliated cells, and hyperplasia were occurred during fluoride exposure. Growth and development were all inhibited at 19.5, 41.9, and 62.7 mg/L fluoride-treated groups after 9 days' exposure. According to real-time PCR results, exposure to fluoride upregulated Dio3 and TRβ mRNA expression and downregulated Dio2 and TRα mRNA level. All above indicated that excessive fluoride could induce morphology malformations, inhibit embryonic growth and development, and disrupt the normal function of maternal thyroid hormone in B. gargarizans embryos. Environ. Mol. Mutagen. 59:123-133, 2018. © 2017 Wiley Periodicals, Inc.

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Section: Introductionmentioning

confidence: 99%

Effects of fluoride on morphology, growth, development, and thyroid hormone of Chinese toad (Bufo gargarizans) embryos

Zhang

Xie

Chai

et al. 2017

Environ and Mol Mutagen

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“…Thus, we choose to use NaF and Na 2 SeO 3 as model compounds in this study. The NaF concentration used in this study ranged from 10 −3 to 10 −2 mol/L, which is in line with that used in a previous study [22]. Furthermore, a Na 2 SeO 3 of 10 −7 mol/L was used according to a previous study [23].…”

Section: Discussionmentioning

confidence: 56%

Simultaneous Administration of Fluoride and Selenite Regulates Proliferation and Apoptosis in Murine Osteoblast-like MC3T3-E1 Cells by Altering Osteoprotegerin

Ren

Wang

Chang

et al. 2011

Biol Trace Elem Res

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The receptor activator nuclear factor kappa-B ligand (RANKL) and its decoy receptor, osteoprotegerin (OPG), are important for maintaining the balance between bone formation and resorption. However, the regulation of microelements on these factors remains unclear. In this study, we used murine osteoblast-like MC3T3-E1 cells to examine the impact of sodium fluoride (NaF) and/or sodium selenite (Na2SeO3) on the OPG/RANKL system. MC3T3-E1 cells were treated with OPG or RANKL siRNA (or left untreated), and subsequently divided into a control group and five experimental groups, which were exposed to different concentrations of NaF and/or Na2SeO3, and subsequently analysed at 24 h. In particular, we examined cell viability, OPG and RANKL mRNA and protein expression, caspase-3 activity, and the cell cycle of the various cell groups. In summary, our findings suggest that the administration of NaF and/or Na2SeO3 affects the expression of OPG in osteoblast-like MC3T3-E1 cells, thereby contributing to the proliferation and apoptosis induced by the OPG.

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“…It is also important to consider the effects of Table 4 Stratified analysis by community of the associations between dental fluorosis (TFI ≥ 4) and weight-for-age (models 1-3) and height-for-age (models 4-6) adjusted for sex, number of teeth, source of drinking water, and use of fluoridated toothpaste.a fluoride on cellular metabolism, which can vary by cell type, over time and by exposure concentration (Barbier et al, 2010). For example, in teeth and bones, micromolar concentrations of fluoride promote cell growth and proliferation, whereas millimolar concentrations of fluoride decrease cell proliferation and cause cell death (Mendoza-Schulz et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Nutritional status and dental fluorosis among schoolchildren in communities with different drinking water fluoride concentrations in a central region in Mexico

Camacho

Pérez

González³

et al. 2016

Science of The Total Environment

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The effects of fluoride on cell migration, cell proliferation, and cell metabolism in GH4C1 pituitary tumour cells

Cited by 41 publications

References 31 publications

Effects of fluoride on morphology, growth, development, and thyroid hormone of Chinese toad (Bufo gargarizans) embryos

Effects of fluoride on morphology, growth, development, and thyroid hormone of Chinese toad (Bufo gargarizans) embryos

Simultaneous Administration of Fluoride and Selenite Regulates Proliferation and Apoptosis in Murine Osteoblast-like MC3T3-E1 Cells by Altering Osteoprotegerin

Nutritional status and dental fluorosis among schoolchildren in communities with different drinking water fluoride concentrations in a central region in Mexico

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