The effects of gene polymorphisms on glioma prognosis

Cui, Ying; Li, Guolin; Yan, Mengdan; Li, Jing; Jin, Tianbo; Li, Shanqu; Mu, Shijie

doi:10.1002/jgm.2989

Cited by 8 publications

(5 citation statements)

References 32 publications

(57 reference statements)

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“…21,22 TNIP1 and TNFα-induced NF-κB activity play key roles in immune diseases and inflammatory responses. 23 Genetic polymorphisms of TNIP1 are also reportedly correlated with elevated risk of gastric carcinoma or glioma prognosis 24,25 ; however, the detailed roles of TNIP1 in glioma still remain to be elucidated. Here, we report that high levels of TNIP1 show a positive correlation with glioma cell proliferation and poor survival in glioma patients.…”

Section: Introductionmentioning

confidence: 99%

TNIP1‐mediated TNF‐α/NF‐κB signalling cascade sustains glioma cell proliferation

Lei

et al. 2019

J Cellular Molecular Medi

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As a malignant tumour of the central nervous system, glioma exhibits high incidence and poor prognosis. Although TNIP1 and the TNF‐α/NF‐κB axis play key roles in immune diseases and inflammatory responses, their relationship and role in glioma remain unknown. Here, we revealed high levels of TNIP1 and TNF‐α/NF‐κB in glioma tissue. Glioma cell proliferation was activated with TNF‐α treatment and showed extreme sensitivity to the TNF receptor antagonist. Furthermore, loss of TNIP1 disbanded the A20 complex responsible for IκB degradation and NF‐κB nucleus translocation, and consequently erased TNFα‐induced glioma cell proliferation. Thus, our investigation uncovered a vital function of the TNIP1‐mediated TNF‐α/NF‐κB axis in glioma cell proliferation and provides novel insight into glioma pathology and diagnosis.

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Section: Introductionmentioning

confidence: 99%

TNIP1‐mediated TNF‐α/NF‐κB signalling cascade sustains glioma cell proliferation

Lei

et al. 2019

J Cellular Molecular Medi

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“…There were some correlations between the expression of ZNF208 gene and the patients’ response to imatinib mesylate in another study of gastrointestinal stromal tumors (). Cui et al ( Cui et al, 2017 ) found that ZNF208 affects the prognosis of glioma. Furthermore, our results demonstrated that SNPs ( Rink et al, 2009 ) (rs8103163 and rs7248488) in ZNF208 are significantly relevant to LC susceptibility ( p = 0.043 and p = 0.025, respectively).…”

Section: Discussionmentioning

confidence: 99%

Genetic Variation in the ZNF208 Gene at rs8103163 and rs7248488 Is Associated With Laryngeal Cancer in the Northwestern Chinese Han Male

et al. 2022

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Background: Laryngeal cancer is more common in middle-aged and older men. We conducted an association analysis between ZNF208 polymorphisms and laryngeal cancer (LC) risk in the Northwestern Chinese Han male.Methods: A total of 352 subjects (172 LC patients and 180 controls) were involved in this study. Agena MassARRAY was used to determine the genotypes. Unconditional logistic regression analysis was performed to explore the relevance.Results: Two SNPs were associated with the risk of LC: rs8103163, OR = 1.41, p = 0.043; rs7248488, OR = 1.45, p = 0.025. Furthermore, rs8103163 was associated with an increased risk of LC under a log-additive model (OR = 1.40, p = 0.042), and rs7248488 was related to a higher risk of LC under a recessive model (OR = 2.33, p = 0.025) and a log-additive model (OR = 1.44, p = 0.026).Conclusions: We first demonstrated that the rs8103163 A allele and the rs7248488 A allele in ZNF208 create susceptibility to laryngeal cancer in the Northwestern Chinese Han male.

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“…The study found that ACYP2 is associated with a variety of tumors or diseases, such as lung cancer (Chen et al, ), colorectal cancer (Liu et al, ), breast cancer (Zhang et al, ), stroke (Liang et al, ), high altitude pulmonary edema (He et al, ). Cui et al researched the influence of telomere related genes on the prognosis of glioma, found that ACYP2 rs843720 influence the overall survival rate, the overall survival rate of glioma patients with mutated genotype was lower than that of wild‐type patients (Cui et al, ). Chen et al recruited 1,156 participants, assessed the relationship between ACYP2 gene polymorphism and lung cancer, and revealed that rs1682111 (A/T) and rs843720 (G/T) in ACYP2 gene promoted the risk of lung cancer (Chen et al, ).…”

Section: Discussionmentioning

confidence: 99%

Associations between polymorphisms of the ACYP2 gene and Liver cancer risk: A case‐control study and meta‐analysis

Zhao¹,

Liu

et al. 2019

Molec Gen & Gen Med

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Background ACYP2 gene may be involved in the process of telomere shortening which may be involved in the liver cancer. So, this research was to examine whether the ACYP2 gene polymorphism has impact on the risk of liver cancer in Chinese population. Methods Two hundred and fifty cirrhosis patients and 248 liver cancer patients were selected. Unconditional logistic regression was to calculate the odds ratio (OR) and 95% confidence intervals (CIs). Analyze the relationship between ACYP2 gene polymorphism and tumor using meta‐analysis. Analyze the expression of ACYP2 gene in liver cancer and its influence on the prognosis of liver cancer by databases (Ualcan, GTEX and Kaplan–Meier plotter). Results In the allele model, ACYP2 rs843720 was protection against the occurrence of cirrhosis developed into liver cancer (OR = 0.76, 95% CI: 0.58–0.99, p = 0.04). Rs1682111 and rs843720 play a protective role in the additive model (rs1682111: OR = 0.69, 95% CI: 0.52–0.93, p = 0.01; rs843720: OR = 0.73, 95% CI: 0.54–0.98, p = 0.04).While rs843645 G allele increased the risk of cirrhosis developed into liver cancer under the additive model (OR = 1.42, 95% CI: 1.02–2.00, p = 0.04).The haplotype analysis detected that “ATATCGCC” decreased the risk of cirrhosis developed into liver cancer (OR = 0.69, 95% CI: 0.51–0.92, 95% CI: p = 0.013); however, “TGAGCGTC” increased the risk of cirrhosis developed into liver cancer (OR = 1.48, 95% CI: 1.04–2.10, p = 0.027). Meta‐analysis shown that ACYP2 rs1682111 was associated with the risk of cancer (OR = 0.90, 95% CI: 0.78–1.05, p = 0.02). ACYP2 gene high expression was found to be associated with better OS for all liver patients. Conclusion Based on this research, we surmised that ACYP2 gene may be involved in the occurrence of liver cancer in Chinese populations.

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The effects of gene polymorphisms on glioma prognosis

Abstract: Age, surgical resection and chemotherapy influenced the survival rates of glioma patients. TERT, MPHOSPH6, ACYP2 and ZNF208 genes were found to affect glioma prognosis.

Cited by 8 publications

References 32 publications

TNIP1‐mediated TNF‐α/NF‐κB signalling cascade sustains glioma cell proliferation

TNIP1‐mediated TNF‐α/NF‐κB signalling cascade sustains glioma cell proliferation

Genetic Variation in the ZNF208 Gene at rs8103163 and rs7248488 Is Associated With Laryngeal Cancer in the Northwestern Chinese Han Male

Associations between polymorphisms of the ACYP2 gene and Liver cancer risk: A case‐control study and meta‐analysis

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