The effects of grape products on metabolic syndrome risk factors: A systematic review and meta-analysis

Silva, Adriele Debortoli da; Izidoro, Natália Oliveira; Macedo, Leandro Roberto de; Matos, Ione Maria de; Silva, Maísa

doi:10.1016/j.phanu.2023.100339

Cited by 2 publications

(1 citation statement)

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“…This fruit has many active polyphenolic compounds, especially resveratrol (Rodriguez‐Lopez et al, 2022; Vislocky & Fernandez, 2010). Recent studies have shown that grapes can be useful in improving lipid profiles (Lupoli et al, 2020), glycemic indices (da Silva et al, 2023), blood pressure (Asbaghi et al, 2021), and some inflammatory markers (Foshati et al, 2021). Although various studies have examined the effect of grape product intervention on liver enzymes, the findings have been inconsistent (Hokayem et al, 2013; Kaliora et al, 2016; Tomé‐Carneiro et al, 2013).…”

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confidence: 99%

Effect of grape‐derived products on the serum levels of enzymes mainly produced by the liver: A systematic review and meta‐analysis of parallel randomized controlled trials

Alhajlah

2024

Phytotherapy Research

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In recent years, an increase in the incidence of liver diseases has been reported all over the world. This study aims to comprehensively summarize and quantitatively analyze the existing evidence concerning the effectiveness of grape‐derived products on liver enzymes through a systematic review and meta‐analytic approach. PubMed, Scopus, Cochrane Library, and ISI Web of Science were comprehensively searched until January 2024. Articles that reported the effect of grape‐derived products on serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) levels were included. Weighted mean differences (WMDs) were pooled using a random‐effects model. Nine studies were included in the meta‐analysis. The results revealed that grape‐derived products did not significantly change the concentrations of ALT (WMD: −2.70 IU/L, 95% CI: −6.14 to 0.75, p = 0.12), and AST (WMD: ‐1.42 IU/L, 95% CI: −3.54 to 0.70, p = 0.18). However, a significant reduction was observed in serum ALP levels (WMD: ‐5.49 IU/L, 95% CI: −9.57 to −1.4, p = 0.008). The present findings suggest that grape‐derived products positively influence serum ALP levels among adults. However, a more comprehensive decision necessitates additional studies.

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Section: Introductionmentioning

confidence: 99%

Effect of grape‐derived products on the serum levels of enzymes mainly produced by the liver: A systematic review and meta‐analysis of parallel randomized controlled trials

Alhajlah

2024

Phytotherapy Research

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Side-streams of wine industry: Insights and learned lessons for making real the vision of reliable pharmacological therapeutics

Fontana

2024

Advances in Botanical Research

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The effects of grape products on metabolic syndrome risk factors: A systematic review and meta-analysis

Cited by 2 publications

References 59 publications

Effect of grape‐derived products on the serum levels of enzymes mainly produced by the liver: A systematic review and meta‐analysis of parallel randomized controlled trials

Effect of grape‐derived products on the serum levels of enzymes mainly produced by the liver: A systematic review and meta‐analysis of parallel randomized controlled trials

Side-streams of wine industry: Insights and learned lessons for making real the vision of reliable pharmacological therapeutics

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