The effects of histamine and serotonin on polymorphonuclear leukocyte accumulation in the rat

Kheifets, Julia; Thieme, Thomas R.; Mirkovich, Anna; Ackerman, Neil R.

doi:10.1016/0014-2999(86)90764-8

Cited by 14 publications

(2 citation statements)

References 19 publications

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“…Histamine H2 receptors are expressed on various cells including neutrophils, macrophages and lymphocytes, and histamine regulates the functions of these cells via H2 receptors 6,7 . In addition, it is reported that histamine inhibits neutrophil chemotaxis in vitro , 8 neutrophil infiltration in vivo , 19,23 and cytokine production in vitro 9,13 . Our findings suggested that endogenous histamine down‐regulates the production of MIP‐2 and TNF‐α (Fig.…”

Section: Discussionsupporting

confidence: 51%

Enhancement of neutrophil infiltration in histidine decarboxylase‐deficient mice

et al. 2002

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SUMMARYThe roles of histamine in the anaphylactic increase in vascular permeability and leucocyte infiltration were analysed in an air pouch-type allergic inflammation model in histidine decarboxylase-deficient (HDC À/À ) mice and wild-type mice. In the immunized wild-type mice, histamine content in the pouch fluid and vascular permeability in the anaphylaxis phase were increased by injection of the antigen solution into the air pouch. However, in the immunized HDC À/À mice, the antigen challenge did not increase histamine content in the pouch fluid and vascular permeability in the anaphylaxis phase. Number of leucocytes (more than 83% are neutrophils) in the pouch fluid 4-24 hr after the antigen challenge in the HDC À/À mice was significantly higher than that in the wildtype mice. Simultaneous injection of histamine with the antigen solution into the air pouch of the immunized HDC À/À mice reduced the antigen-induced leucocyte infiltration at 4 hr. Simultaneous injection of the H2 antagonist cimetidine but not the H1 antagonist pyrilamine with the antigen solution into the air pouch of the immunized wild-type mice further increased leucocyte infiltration at 4 hr. The levels of macrophage inflammatory protein-2 at 2 hr and of tumour necrosis factor-a at 4 hr in the pouch fluid of the HDC À/À mice were significantly higher than those of the wild-type mice. These findings indicate that histamine plays significant roles not only in the anaphylactic increase in vascular permeability via H1 receptors but also in the negative regulation of neutrophil infiltration via H2 receptors in allergic inflammation.

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Section: Discussionsupporting

confidence: 51%

Enhancement of neutrophil infiltration in histidine decarboxylase‐deficient mice

et al. 2002

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“…Basic physiological effects of histamine are known to be determined by its interaction with H 1 , H 2 , H 3 , and H 4 types of cell receptors. In particular, it was shown that histamine through H 2 -receptors inhibits an ability of neutrophils to produce ROS in response to different stimuli [Burde et al, 1989;Ching et al, 1995;Betten et al, 2003], suppresses the chemotaxis of neutrophils and monocytes [Radermecker et al, 1989;, decreases the neutrophil infiltration [Kheifets et al, 1986;Hirasawa et al, 2002], reduces adhesion protein expression on monocytes [Itoh et al, 2002], and depresses proliferation of T-lymphocytes . The expressed anti-inflammatory effects of histamine were demonstrated in an inflammatory model in histamine-deficient mice generated by a disruption of the gene for histidine decarboxylase, the unique histamine-synthesizing enzyme [Hirasawa et al, 2002;Hori et al, 2002].…”

Section: Discussionmentioning

confidence: 99%

Anti‐inflammatory effects of low‐intensity extremely high‐frequency electromagnetic radiation: Frequency and power dependence

Gapeyev

Mikhailik

Chemeris

2007

Bioelectromagnetics

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Using a model of acute zymosan-induced footpad edema in NMRI mice, the frequency and power dependence of anti-inflammatory effect of low-intensity extremely high-frequency electromagnetic radiation (EHF EMR) was found. Single whole-body exposure of animals to EHF EMR at the intensity of 0.1 mW/cm(2) for 20 min at 1 h after zymosan injection reduced both the footpad edema and local hyperthermia on average by 20% at the frequencies of 42.2, 51.8, and 65 GHz. Some other frequencies from the frequency range of 37.5-70 GHz were less effective or not effective at all. At fixed frequency of 42.2 GHz and intensity of 0.1 mW/cm(2), the effect had bell-shaped dependence on exposure duration with a maximum at 20-40 min. Reduction of intensity to 0.01 mW/cm(2) resulted in a change of the effect dependence on exposure duration to a linear one. Combined action of cyclooxygenase inhibitor sodium diclofenac and EHF EMR exposure caused a partial additive effect of decrease in footpad edema. Combined action of antihistamine clemastine and EHF EMR exposure caused a dose-dependent abolishment of the anti-inflammatory effect of EHF EMR. The results obtained suggest that arachidonic acid metabolites and histamine are involved in realization of anti-inflammatory effects of low-intensity EHF EMR.

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Anti-Inflammatory Effects of Low-Intensity Millimeter Wave Radiation

Gapeyev

Shumilina

Lushnikov

et al. 2006

BIOELECTROMAGNETICS Current Concepts

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The effects of histamine and serotonin on polymorphonuclear leukocyte accumulation in the rat

Cited by 14 publications

References 19 publications

Enhancement of neutrophil infiltration in histidine decarboxylase‐deficient mice

Enhancement of neutrophil infiltration in histidine decarboxylase‐deficient mice

Anti‐inflammatory effects of low‐intensity extremely high‐frequency electromagnetic radiation: Frequency and power dependence

Anti-Inflammatory Effects of Low-Intensity Millimeter Wave Radiation

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