The Effects of Hydrophilic Polyethylene Glycol-Based Adhesion Barrier Use to Prevent Intra-abdominal Adhesions in Intra-abdominal Sepsis Model

Özbalcı, Gökhan Selçuk; Sulaimanov, Marlen; Hazinedaroğlu, Selçuk; Törüner, Attila

doi:10.1007/s12262-013-0852-1

Cited by 3 publications

(3 citation statements)

References 19 publications

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“…Barrier attachment to oozing surfaces is an important factor to ensure the anti-adhesion effect is maintained, particularly during surgeries that include a high risk of bleeding 148 . Overall, natural barriers seem to maintain more effective anti-adhesion effects on oozing surfaces.…”

Section: Discussionmentioning

confidence: 99%

Barrier materials for prevention of surgical adhesions: systematic review

et al. 2022

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Background Postoperative surgical adhesions constitute a major health burden internationally. A wide range of materials have been evaluated, but despite constructive efforts and the obvious necessity, there remains no specific barrier widely utilized to prevent postoperative adhesion formation. The aim of this study was to highlight and characterize materials used for prevention of postoperative surgical adhesions in both animal and human studies. Methods A systematic review was performed of all original research articles presenting data related to the prevention of postoperative adhesions using a barrier agent. All available observational studies and randomized trials using animal models or human participants were included, with no restrictions related to type of surgery. PubMed and Embase databases were searched using key terms from inception to August 2019. Standardized data collection forms were used to extract details for each study and assess desirable characteristics of each barrier and success in animal and/or human studies. Results A total of 185 articles were identified for inclusion in the review, with a total of 67 unique adhesion barrier agents (37 natural and 30 synthetic materials). Desirable barrier characteristics of an ideal barrier were identified on review of the literature. Ten barriers achieved the primary outcome of reducing the incidence of postoperative adhesions in animal studies followed with positive outputs in human participants. A further 48 materials had successful results from animal studies, but with no human study performed to date. Discussion Multiple barriers showed promise in animal studies, with several progressing to success, and fulfilment of desirable qualities, in human trials. No barrier is currently utilized commonly worldwide, but potential barriers have been identified to reduce the burden of postoperative adhesions and associated sequelae.

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Section: Discussionmentioning

confidence: 99%

Barrier materials for prevention of surgical adhesions: systematic review

et al. 2022

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“…In light of the above, it would be preferable to use monofilament sutures of a smaller calibre. The titanium coated clips used in laparoscopy are biologically inert and therefore reduce the inflammatory insult compared to sutures [ 34 ], hence, resulting in a lower risk of adhesions. It is essential that the intraperitoneal tissues and viscera are treated with extreme care to avoid vascular damage [ 35 ], maintain meticulous debridement and peritoneal detachment and avoid unnecessary viscerolysis.…”

Section: Postoperative Adhesionsmentioning

confidence: 99%

Prevention and treatment of peritoneal adhesions in patients affected by vascular diseases following surgery: a review of the literature

Rocca

Aprea

Surfaro³

et al. 2016

Open Medicine

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AbstractIntra-abdominal adhesions are the most frequently occurring postoperative complication following abdomino-pelvic surgery. Abdominal and pelvic surgery can lead to peritoneal adhesion formation causing infertility, chronic pelvic pain, and intestinal obstruction. Laparoscopy today is considered the gold standard of care in the treatment of several abdominal pathologies as well as in a wide range of vascular diseases. Laparoscopy has several advantages in comparison to open surgery. These include rapid recovery times, shorter hospitalisation, reduced postoperative pain, as well as cosmetic benefits. The technological improvements in this particular surgical field along with the development of modern techniques and the acquisition of specific laparoscopic skills have allowed for its wider utilization in operations with fully intracorporeal anastomoses. Postoperative adhesions are caused by aberrant peritoneal healing and are the leading cause of postoperative bowel obstruction. The use of anti-adherence barriers is currently being advocated for their prevention. The outcome of the investigation showed adhesion formation inhibition without direct detrimental effects on anastomotic healing. Poor anasto-motic healing can provoke adhesions even in the presence of anti-adhesion barriers. This review gives a short overview on the current evidence on the pathophysiology and prevention of peritoneal adhesions.

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“…Complications generated by PAA can result in numerous problems, such as chronic abdominal pain, small bowel obstruction, infertility in women, and even the secondary surgery [3,4]. Furthermore, 40% of intestinal obstruction is caused by PAA [5].…”

Section: Introductionmentioning

confidence: 99%

Application of Traditional Chinese Medicines in Postoperative Abdominal Adhesion

Liu

Feng

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Adhesion is a frequent complication after abdominal surgery. Although various methods have been applied to prevent and treat postoperative abdominal adhesion (PAA), few modern drugs designed for clinical applications have reached the expected preventive or therapeutic effect so far. There is an imperative to develop some new strategies for the treatment of PAA. Traditional Chinese medicine (TCM) has been widely practiced for thousands of years and played an indispensable role in the prevention and treatment of diseases. Modern medicine researchers have accepted the therapeutic effects of many active components derived from Chinese medicinal herbs. The review stresses the most commonly used TCM treatment, including Chinese medicinal herbals and monomers, TCM formulas, and acupuncture treatment.

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The Effects of Hydrophilic Polyethylene Glycol-Based Adhesion Barrier Use to Prevent Intra-abdominal Adhesions in Intra-abdominal Sepsis Model

Cited by 3 publications

References 19 publications

Barrier materials for prevention of surgical adhesions: systematic review

Barrier materials for prevention of surgical adhesions: systematic review

Prevention and treatment of peritoneal adhesions in patients affected by vascular diseases following surgery: a review of the literature

Application of Traditional Chinese Medicines in Postoperative Abdominal Adhesion

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