The effects of hypophysectomy on the digestive glands of the mouse

Koerker, Richard M.

doi:10.1002/aja.1001210309

Cited by 8 publications

(6 citation statements)

References 41 publications

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“…Any experimental condition that acts on their homeostasis may potentially induce diffuse salivary gland atrophy. This has been shown for hypophysectomy ( Koerker 1967 ), adrenalectomy, denervation and α- and β-adrenergic antagonists. Also decreased food consumption, and protein starvation lead to salivary gland atrophy.…”

Section: Salivary Glandsmentioning

confidence: 71%

Nonproliferative and Proliferative Lesions ofthe Gastrointestinal Tract, Pancreas andSalivary Glands of the Rat and Mouse

et al. 2016

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The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) project is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP), and North America (STP) to develop an internationally accepted nomenclature and diagnostic criteria for nonproliferative and proliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature and diagnostic criteria for classifying lesions in the digestive system including the salivary glands and the exocrine pancreas of laboratory rats and mice. Most lesions are illustrated by color photomicrographs. The standardized nomenclature, the diagnostic criteria, and the photomicrographs are also available electronically on the Internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous and age related lesions as well as lesions induced by exposure to test items. Relevant infectious and parasitic lesions are included as well. A widely accepted and utilized international harmonization of nomenclature and diagnostic criteria for the digestive system will decrease misunderstandings among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.

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Section: Salivary Glandsmentioning

confidence: 71%

Nonproliferative and Proliferative Lesions ofthe Gastrointestinal Tract, Pancreas andSalivary Glands of the Rat and Mouse

et al. 2016

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“…However, these authors also failed to find granulated cells in the ducts of the sublingual glands of these androgen treated mice. By contrast, Koerker (1967), in his study of the effects of hypophysectomy on digestive glands of the male mouse, saw scattered granulated striated duct cells in the submandibular glands of about one-third of his intact controls, but not in any of the hypophysectomized mice, implying that these cells are hormonally dependent. However, although sublingual striated duct cells are responsive to androgens, these ducts should not be regarded as sexually dimorphic in intact adult mice because of the infrequent and inconsistent presence of granulated cells.…”

Section: Hormonally Treated Female Micementioning

confidence: 95%

“…The GCT segment has been described only in the submandibular gland of rodents (Pinkstaff, 1980). However, Koerker (1967) observed a few scattered cells within the striated ducts of the sublingual gland of the mouse which contained abundant apical granules, strongly resembling submandibular GCT cells. Berkman and Kronman (1970), however, found no granulated cells in the mouse sublingual striated ducts, even after prolonged treatment with androgens.…”

mentioning

confidence: 99%

Epidermal growth factor, renin, and protease in hormonally responsive duct cells of the mouse sublingual gland

Gresik

Barka

1983

Anat. Rec.

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In the striated ducts of the sublingual glands of normal adult male, but not female, Swiss-Webster mice a few scattered cells have apical secretion granules. These sublingual duct cells resemble the granular convoluted tubule (GCT) cells of the submandibular glands of adult female mice, in that they are smaller than submandibular GCT cells of adult males, and contain fewer apical granules, and prominent basal striations. These cells stain immunocytochemically for epidermal growth factor (EGF), renin, and protease A. Such granular striated duct cells could be induced in the sublingual glands of adult female mice by treatment with either testosterone propionate or thyroxine; the two hormones given simultaneously acted synergistically in this induction.

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“…However, a few scattered granular cells are accounted within the SDs of the mouse SLG (Koerker, 1967), and their ultrastructure is strongly resembling submandibular GCT cells . They are observed in male but not in female .…”

mentioning

confidence: 99%

Role of thyroid hormone in the initiation of EGF (epidermal growth factor) expression in the sublingual gland of the postnatal mouse

et al. 2005

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The effect of triiodo-L-thyronine (T 3 ) and propylthiouracil (PTU) on the initiation of epidermal growth factor (EGF) expression in the sublingual glands (SLGs) of postnatal mice was investigated by indirect enzyme-labeled and immunogold antibody methods for light and electron microscopy, respectively. In normal males, EGF immunoreactivity first appeared in a few scattered granular cells of striated ducts (SDs) at 5 weeks of age, and the immunoreactive cells had increased in number at 6 weeks of age. No EGF expression was observed in the glands of females at any ages examined. When T 3 (1 mg/kg body weight) was given to males every other day for 2 weeks before examination, EGF expression began earlier; the immunoreactive granular cells were first detected at 4 weeks of age, and at later ages they were markedly increased in number compared to those of normal males. Moreover, T 3 was capable of inducing EGF in the female glands. After T 3 was administered to females in the same manner as in males, a few immunoreactive cells were first detected at 5 weeks of age, and increased numbers were detected at later ages. By contrast, when PTU (1 mg/kg body weight) was given to male mice every other day for 2 weeks before examination, the EGF-immunoreactive cells were markedly decreased in number compared to those of normal males of the same age. Electron microscopy revealed that many SD cells contained secretory granules, and that these cells constituted the granular striated tubule (GST) in a portion of SDs, but they were undetectable by light microscopy, because their secretory granules were minimal in size and few in number. Gold-labeling of EGF was confined to the secretory granules of scattered granular cells, whose secretory granules were far larger in size and more abundant than those of the GST cells. These results suggest that thyroid hormone is essential to differentiation of the cellular phenotype of GST precursor cells into typical granular cells (detectable by light microscopy) that express EGF in the mouse SLG, showing a close resemblance to the submandibular granular convoluted tubule cells.

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The effects of hypophysectomy on the digestive glands of the mouse

Cited by 8 publications

References 41 publications

Nonproliferative and Proliferative Lesions ofthe Gastrointestinal Tract, Pancreas andSalivary Glands of the Rat and Mouse

Nonproliferative and Proliferative Lesions ofthe Gastrointestinal Tract, Pancreas andSalivary Glands of the Rat and Mouse

Epidermal growth factor, renin, and protease in hormonally responsive duct cells of the mouse sublingual gland

Role of thyroid hormone in the initiation of EGF (epidermal growth factor) expression in the sublingual gland of the postnatal mouse

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