The Effects of Ananas comosus L. Leaves on Diabetic-Dyslipidemic Rats Induced by Alloxan and a High-Fat/High-Cholesterol Diet

Abstract

The aim of this study is to demonstrate the effects of Ananas comosus L. leaves on diabetic-dyslipidemic rats. Hypoglycemic and hypolipidemic activities of the ethanolic extract of Ananas comosus L. leaves (EEACL) were evaluated in normal and alloxan-induced diabetic rats by oral glucose tolerance test and an olive oil load test. Anti-diabetic, anti-hyperlipidemic and anti-oxidative activities of EEACL were also investigated in diabetic-dyslipidemic rats induced by alloxan and a high-fat/high-cholesterol diet. EEACL at the dose of 0.40 g/kg significantly inhibited the increase in blood glucose in diabetic rats in oral glucose tolerance test, but did not cause any hypoglycerimic activity in normal rats. It also significantly inhibited the increase in postprandial triglycerides (TG) levels in both normal and diabetic rats in olive oil load test. After 15 days of treatment of diabetic dyslipidemic rats, EEACL significantly decreased blood glucose (-51.0%, P < 0.01), TG (-50.1%, P < 0.01), TC (-23.3%, P < 0.01), LDL-c (-47.9%, P < 0.01) and glycated albumin (-25.4%, P < 0.01) levels, significantly increased serum high-density lipoprotein cholesterol levels (66.2%, P < 0.01) and prevented lower body weight of diabetes (11.8%, P < 0.05), significantly lowered lipid peroxidation productions of blood (-27.8%, P < 0.01), brain (-31.6%, P < 0.05), liver (-44.5%, P < 0.01) and kidneys (-72.2%, P < 0.05) compared with those in untreated diabetic dyslipidemic rats. These data suggest that EEACL has anti-diabetic, anti-dyslipidemic and anti-oxidative activities, which may be developed into a new plant medicine for treatment of diabetes and its complications.

Hypocholesterolemic Effect of Ethanol Extract of Ananas comosas (L.) Merr. Leaves in High Cholesterol Fed Albino Rats

“…The effect of 500 mg/kg body weight of leave extract has been shown to lessen TC, TG and LDL-c level and increase HDL-c level which is very much similar to the previous data (Weidong et al 2005). The 500 mg/kg body weight of the leave extract of Ananas comosas (L.) Merr.…”

“…significantly decrease TG (-49.09%, P‹0.01), TC (-42.02%, P‹0.01), LDL-c (-51.15%, P‹0.01) and significantly increased HDL-c levels (+5.41%, P‹0.01). This effect of the AC extract on lipid profile is poorly supported by the previous data (Weidong et al 2005).…”

“…In both cases TC, TG and LDL-c levels were reduced. But in the previous experiment showed the increase of HDLc levels where the present study showed its decline in case of using 1000 mg/kg body weight of AC extract (Weidong et al 2005).…”

Utilization of Pineapple Waste: A Review

“…The ethanolic extract of pineapple leaves containing phenolics have shown to inhibit the increase in blood glucose in diabetic rats as well as inhibit the increase in postprandial triglycerides (Xie et al, 2005). The other report on the ethanolic extracts of pineapple leaves have shown to content high amount of phytochemicals including p-coumaric acid, 1-o-pcoumaroylglycerol, caffeic acid and 1-o-caffeoylglycerol (Xie et al, 2006).…”

Metabólitos secundários da família bromeliaceae

“…25 Estudos de extratos etanólicos das folhas de A. comosus mostraram efeitos antidiabético, anti-hiperlipidimêmico e antioxidante. 26 Estudos recentes do mesmo grupo de pesquisa com o objetivo de investigar a sensibilidade à insulina em ratos diabéti-cos e células HepG2 foram otimistas. Os resultados sugerem que os extratos de A. comosus podem aumentar a sensibilidade à insulina em ratos com diabetes do tipo II.…”