The Effects ofMomordica balsaminaMethanolic Extract on Kidney Function in STZ-Induced Diabetic Rats: Effects on Selected Metabolic Markers

Abstract

Background Studies suggest that Momordica balsamina (intshungu) possesses hypoglycaemic effects. The effects of Momordica balsamina on diabetic complications such as DN, however, have not been established. Accordingly, this study seeks to investigate the effects of M. balsamina on kidney function in STZ-induced diabetic rats. Methods Methanolic extracts (ME) of M. balsamina's leaves were used in this study. Short-term effects of M. balsamina methanolic extract on kidney function and MAP were studied in STZ-induced diabetic rats treated twice daily with M. balsamina methanolic extract (250 mg/kg), insulin (175 μg/kg, s.c.), and metformin (500 mg/kg) for 5 weeks. Results M. balsamina methanolic extract significantly increased Na+ excretion outputs in STZ-induced diabetic rats by comparison to STZ-diabetic control rats. M. balsamina methanolic extract significantly increased GFR in STZ-diabetic rats with a concomitant decrease in creatinine concentration and also reduced kidney-to-body ratio, albumin excretion rate (AER), and albumin creatinine ratio (ACR). M. balsamina methanolic extract significantly reduced MAP in STZ-diabetic animals by comparison with STZ-diabetic control animals. These results suggest that M. balsamina methanolic extract not only lowers blood glucose but also has beneficial effects on kidney function and blood pressure. Conclusion These findings suggest that M. balsamina may have beneficial effects on some processes that are associated with renal derangement in STZ-induced diabetic rats.

The Haematological Effects of Oleanolic Acid in Streptozotocin-Induced Diabetic Rats: Effects on Selected Markers

“…The short-term effects of OA were monitored for haematological parameters in separate groups of untreated and treated STZ-induced diabetic male Sprague-Dawley rats for 5 weeks using a previously validated standard protocol that has been reported from our laboratories [27]. Briefly, OA (80 mg/kg p.o) was administered twice every third day at 09:00 and 15:00 in separate groups of rats by means of a bulbed steel tube.…”

“…To acquire data, the BD FACS Canto-II flow cytometer and BD FACSdiva software (BD Biosciences, San Jose, CA) were used following a previously described protocol [27].…”

Bridelia ferruginea Benth leaves attenuates diabetes nephropathy in STZ-induced rats via targeting NGAL/KIM-1/cystatin c gene

“…Hyperglycemiainduced oxidative stress in diabetes is a major cause for the development of diabetic complication such as diabetes nephropathy [3]. This pathway is mainly activated by sustained hyperglycemia which causes the intra-renal haemodynamic's changes through glycosylation of intrarenal proteins that induce hyperfiltration and glomerular dysfunction [4]. Chemotherapy remains the kernel of diabetes management, but most individuals with chronic diabetes condition in developing countries rely on phytotherapy which involve traditional medicines alone or synergistically with orthodox drugs.…”

Biochemical Activity and Hypoglycemic Effects ofRumex obtusifoliusL. Seeds Used in Armenian Traditional Medicine

“…Hyperglycemia is a metabolic disorder of the endocrine system characterized by abnormal glucose metabolism which is demonstrated by high blood sugar (hyperglycemia), hypercholesterolemia, high blood pressure, and cardiovascular disease due to the disturbances of carbohydrate, lipid, and protein metabolism resulting from insulin resistant and β -cell dysfunction [ 1 – 3 ]. Dyslipidemia is a very frequent metabolic disorder which is characterized by an increase of the rates of triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL), and reduction of the high-density lipoprotein (HDL) [ 4 – 6 ]. It is known that hypercholesterolemia contributes to development of the atherosclerosis and subsequent of hypertension, ischemic heart disease, and renal failure [ 3 , 6 ].…”

“…Dyslipidemia is a very frequent metabolic disorder which is characterized by an increase of the rates of triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL), and reduction of the high-density lipoprotein (HDL) [ 4 – 6 ]. It is known that hypercholesterolemia contributes to development of the atherosclerosis and subsequent of hypertension, ischemic heart disease, and renal failure [ 3 , 6 ].…”