The effects of intravenously infused catecholamines on hepatic blood flow in conscious dogs with experimental obstructive jaundice

Abstract

This study was conducted to examine how the effects of dopamine and dobutamine on hepatic blood flow were influenced by obstructive jaundice in a conscious canine model. Prior to biliary obstruction, portal venous blood flow (PVF) increased in response to the infusion of either dopamine or dobutamine: dopamine infused at 8 micrograms/kg per min produced an increase of 19 +/- 0% in PVF, while dobutamine infused at 16 micrograms/kg per min produced an increase of 30 +/- 2%. Although hepatic arterial blood flow (HAF) decreased dose-dependently in response to the infusion of dopamine, no significant change was observed in HAF in response to any dose of dobutamine. Obstructive jaundice attenuated or completely abolished the PVF-increasing effect of dopamine, whereas it did not significantly alter the effect of dobutamine on hepatic blood flow. In dogs with obstructive jaundice, dopamine at 16 micrograms/kg per min produced a decrease of 17 +/- 3% in PVF. These findings suggest that dobutamine is more effective than dopamine for increasing hepatic blood flow in patients with obstructive jaundice.

Aggressive preoperative management and extended surgery for hilar cholangiocarcinoma: Nagoya experience

“…Clinical and experimental studies on portal vein embolization offer revolutionary progress in liver surgery and have actually increased resectability and the safety of major liver resection for advanced hilar cholangiocarcinoma ,. Hemodynamic studies on the perioperative condition of the cholestatic liver have also contributed to safer management of surgical patients . Major liver resection with extended autonomic nerve and lymph node dissection has been performed in Nagoya University Hospital to overcome bile duct carcinoma with perineural invasion, which is an inherent characteristic and major prognostic factor of biliopancreatic cancers,76,77 and we have emphasized here some benefits of this type of surgery.…”

“…[32][33][34][35][36][37][58][59][60][61][62][63][64][65][66][67] Hemodynamic studies on the perioperative condition of the cholestatic liver have also contributed to safer management of surgical patients. [68][69][70][71][72][73][74][75] Major liver resection with extended autonomic nerve and lymph node dissection has been performed in Nagoya University Hospital to overcome bile duct carcinoma with perineural invasion, which is an inherent characteristic and major prognostic factor of biliopancreatic cancers, 76,77 and we have emphasized here some benefits of this type of surgery. However, not only the advantages but also the hazards of the extended surgery should be carefully evaluated by both Eastern and Western surgeons because autonomic nerve dissection may confer some unknown effects on the surgical patients.…”

Negative impact of systemic catecholamine administration on hepatic blood perfusion after porcine liver transplantation

“…This variation could indicate that the basal autonomic tone in the portal vein is sometimes very low, and PVF is primarily dependent on splanchnic blood flow, which is influenced by the vasomotor tone of the superior mesenteric artery 50. There is also discrepancy concerning the effects of denervation on HAF, but in most studies, an increment of HAF was reported after denervation 16, 50–54…”

Effects of Prostaglandin E₁ on Hepatic Blood Flow in Conscious Dogs with Chronic Biliary Obstruction

“…Takagi et al [13] and Kato et al [14] have reported the influence of feeding, cholestasis with biliary obstruction [15,16] and hepatectomy [17,18] in the splanchnic circulation in conscious dogs. The purpose of this study is to evaluate the effects of PGE 1 in conscious dogs with experimental obstructive jaundice and to determine the optimal dose of PGE 1 in cholestasis.…”