The Effects of Iron Deficiency on the Gut Microbiota in Women of Childbearing Age

Abstract

Iron deficiency anemia (IDA) is the most prevalent and common nutritional deficiency worldwide and is a global health problem with significant risk, particularly among women of reproductive age. Oral iron supplementation is the most widely used and cost-effective treatment for iron deficiency and IDA. However, there are limitations regarding side effects such as enteritis, treatment compliance, and bioavailability. Intestinal microbiome characteristic research has been recently conducted to overcome these issues, but more is needed. Against this background, a metagenomics study on the 16S gene in the feces of young women vulnerable to IDA was conducted. As a result of analyzing 16 normal subjects and 15 IDA patients, significant differences in bacterial community distribution were identified. In particular, a significant decrease in Faecalibacterium was characteristic in IDA patients compared with normal subjects. Furthermore, in the case of patients who recovered from IDA following iron supplementation treatment, it was confirmed that Faecalibacterium significantly recovered to normal levels. However, no significance in beta diversity was seen compared with before treatment. There were also no differences in the beta diversity results between the recovered and normal subjects. Therefore, intestinal dysbiosis during the disease state was considered to be restored as IDA improved. Although the results were derived from a limited number of subjects and additional research is needed, the results of this study are expected to be the basis for developing treatment and prevention strategies based on host–microbiome crosstalk in IDA.

Nutrition in chronic inflammatory conditions: Bypassing the mucosal block for micronutrients

“…A reduced nutritional intake is known to shift the gut microbiome. For example, iron deficiency results in a reduction of Bifidobacterium , 210–212 Bacteroides , 213 and Faecalibacterium 214 and causes a shift in SCFA 215 as well as siderophore‐production, 213 while an increase of the Actinobacteria phylum 216–218 is reported. Vitamin A deficiency rather promotes Enterococcus in children with diarrhea, 219 while Bacteroides and Bifidobacterium are decreased 220 …”

Efficacy of lyophilized Lactobacillus sakei as a potential candidate for the prevention of carbapenem-resistant Klebsiella infection

“…In addition, qPCR was carried out using a LightCycler 480® (BioRad Diagnostics, USA) based on SYBR Green detection (SYBR Green 2× Master mix; Qiagen, USA) with the same primers as described above. A triplicate reaction of each sample (Candidate stain, L. curvatus KGMB 05016, and L. rhamnosus KGMB 06348) and the PCR conditions optimized as described in (Seo et al, 2023).…”

Pathogenetic Effects of Bacteria of the Genus <i>Desulfovibrio</i>. Experimental Study. Part One: Iron Metabolism

“…когнитивные функции подопытных животных оценивались 4 раза (1, 4, 14, 36-й дни эксперимента). известно, что железодефицитная анемия (жда) связана с дисбактериозом желудочно-кишечного тракта [14][15][16][17][18][19]. в исследованиях н. Seo et al выявлено, что по мере улучшения показателей уровня железа в организме пациентов с жда кишечный микробиоценоз восстанавливался [14].…”