The effects of ischemia and reperfusion on intestinal motility

Protective Effect of Proteinase-Activated Receptor 2 Activation on Motility Impairment and Tissue Damage Induced by Intestinal Ischemia/Reperfusion in Rodents

“…Loss of mucosal integrity has been implicated in the pathogenesis of the multiple organ dysfunction syndrome, a life-threatening complication of intestinal ischemia, which may be caused by a hyper-inflammatory response and by the loss of autoregulation of the normal inflammatory response. 18 Alterations of gastrointestinal motility, 8,41,42 which can be partly due to structural changes and neuronal plasticity occurring within the enteric nervous system, 29,43 may also contribute to the development of bacterial overgrowth with subsequent bacterial translocation. Mast cells degranulation has been recognized as an important factor in mediating mucosal damage and motor alterations in small bowel.…”

Tempol reduces bacterial translocation after ischemia/reperfusion injury in a rat model of superior mesenteric artery occlusion

“…Previous research has shown that mesenteric I/R not only produces mucosal damage, but also induces alterations of intestinal motor activity with a delay in the gastrointestinal transit time. [30][31][32] These alterations can be the result of structural and neuronal changes occurring within the enteric nervous system, which may play a role in the progress of bacterial overgrowth with subsequent translocation caused by inadequate bacterial clearance. 30,33,34 The administration of Tempol signifi cantly decreased histological damage (Table 3) and PMN infi ltration in intestinal tissue specimens when compared with the I/ R-treated animals (group 2).…”

Giant Pediatric Omental Cyst: A Case Report and Review of Literature

“…The omental cyst are multicolucular or unilocular and mostly contain serous fluid. Sometimes hemorrhagic, chylous or infected fliud can be detected [5,6]. Our patient had multilocular cyst with size of 30x25 cm with almost 8 liters of fluid.…”