The effects of isoflurane anesthesia and mechanical ventilation on renal function during endotoxemia

Frithiof, Robert; Soehnlein, Oliver; Eriksson, Sven V.; Fenhammar, Johan; Hjelmqvist, Hans; Lindbom, Lennart; Rundgren, Mats

doi:10.1111/j.1399-6576.2011.02406.x

Cited by 27 publications

(25 citation statements)

References 46 publications

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“…Septic AKI is generally believed to be due to regional hypoperfusion causing renal ischemia [2]. However, recent experimental reports indicate that AKI may develop even though renal blood flow and blood pressure remain within physiological limits [3][4][5]. Thus, it is possible that the pathogenesis of septic AKI is complicated by factors other than ischemia.…”

Section: Introductionmentioning

confidence: 98%

Renal effects of treatment with a TLR4-inhibitor in conscious septic sheep

Fenhammar¹,

Rundgren²,

Hultenby³

et al. 2014

Crit Care

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Introduction: Acute kidney injury (AKI) is a common and feared complication of sepsis. The pathogenesis of sepsis-induced AKI is largely unknown, and therapeutic interventions are mainly supportive. In the present study, we tested the hypothesis that pharmacological inhibition of Toll-like receptor 4 (TLR4) would improve renal function and reduce renal damage in experimental sepsis, even after AKI had already developed. Methods: Sheep were surgically instrumented and subjected to a 36-hour intravenous infusion of live Escherichia coli. After 12 hours, they were randomized to treatment with a selective TLR4 inhibitor (TAK-242) or vehicle.

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Section: Introductionmentioning

confidence: 98%

Renal effects of treatment with a TLR4-inhibitor in conscious septic sheep

Fenhammar¹,

Rundgren²,

Hultenby³

et al. 2014

Crit Care

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“…The cytokine response is a key link of the early inflammatory response. With the accumulation of large amounts of inflammatory cytokines, lung injury during the peri-operative period is mainly an acute process (7). Expression of pro-inflammatory cytokines and imbalance of pro-inflammatory/anti-inflammatory cytokines has an essential role in lung injury during the peri-operative period (8).…”

Section: Introductionmentioning

confidence: 99%

“…The effect of isoflurane on the respiratory system is extensive and complex (6). It influences the pulmonary surfactant and inflammatory response of the lungs (7). The cytokine response is a key link of the early inflammatory response.…”

Section: Introductionmentioning

confidence: 99%

Resveratrol protects neuronal cells from isoflurane‑induced inflammation and oxidative stress‑associated death by attenuating apoptosis via Akt/p38 MAPK signaling

Yang

et al. 2017

Exp Ther Med

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Abstract. The aim of the present study was to determine whether resveratrol protects neuronal cells from inflammation and isoflurane-induced oxidative stress-associated death via attenuating apoptosis via Akt/p38 mitogen-activated protein kinase (MAPK) signaling. The PC12 rat pheochromocytoma cell line was treated with 2% isoflurane + 21% O 2 + 5% CO 2 for 6 h and pre-treated with resveratrol (0-1,000 µM) for 0, 24 or 48 h prior to isoflurane treatment. An MTT assay, flow cytometry and ELISA of tumor necrosis factor-α, interleukin-6, malondialdehyde and superoxide dismutase revealed that resveratrol reduced growth inhibition, restrained apoptosis and suppressed inflammation and oxidative stress induced by isoflurane in PC12 cells. Pretreatment with resveratrol effectively reduced caspase-3 activity and inducible nitric oxide synthase protein expression in isoflurane-induced PC12 cells. In addition, western blot analysis demonstrated that resveratrol treatment significantly attenuated isoflurane-induced decreases in the activated phosphorylated (p)-Akt/Akt ratio and increases in the p-p38/p38 MAPK protein ratio in PC12 cells. These findings indicated that resveratrol was able to protect neuronal cells from isoflurane-induced inflammation and oxidative stress-associated death by attenuating apoptosis via Akt/p38 MAPK signaling.

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“…Anaesthesia with isofluorane is known to have specific effects on hemodynamics (blunting of the tachycardic response, hypotension, decreased cardiac output) and on the kidney (oliguria, leukocyte activation, decreased creatinine clearance, decreased sodium excretion, decreased renal blood flow) [29,30]. It is unknown how such effects might influence the impact of live E. coli infusion on renal ATP levels.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

Renal bioenergetics during early gram-negative mammalian sepsis and angiotensin II infusion

et al. 2012

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The effects of isoflurane anesthesia and mechanical ventilation on renal function during endotoxemia

Abstract: The results of the current study suggest that isoflurane anesthesia (minimum alveolar concentration 1.0) with mechanical ventilation aggravates renal dysfunction during 48 h of endotoxemia and does not significantly reduce the inflammatory response or signs of tubular damage.

Cited by 27 publications

References 46 publications

Renal effects of treatment with a TLR4-inhibitor in conscious septic sheep

Renal effects of treatment with a TLR4-inhibitor in conscious septic sheep

Resveratrol protects neuronal cells from isoflurane‑induced inflammation and oxidative stress‑associated death by attenuating apoptosis via Akt/p38 MAPK signaling

Renal bioenergetics during early gram-negative mammalian sepsis and angiotensin II infusion

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