The effects of lead and aluminum exposure on congenital heart disease and the mechanism of oxidative stress

Liu, Zhen; He, Chunhua; Chen, Ming; Yang, Shuihua; Li, Jun; Lin, Yuan; Deng, Ying; Li, Nana; Guo, Yi-Xiong; Yu, Ping; Li, Xiaohong

doi:10.1016/j.reprotox.2018.07.081

Cited by 54 publications

(29 citation statements)

References 38 publications

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“…An area of Italy polluted with lead from ceramic factories was found to have a higher incidence of cardiovascular defects, which decreased with time after the pollution was caused [ 61 ], while an investigation of paternal employment in a US microelectronics/business machine manufacturing facility found that lead exposure was associated with increased risk of ventricular septal defect, with OR 2.7 (95% CI: 1.09, 6.67) [ 62 ]. A recent study investigated cord blood and found that presence of aluminum was associated with higher incidence of CHDs, with OR 2.08 (95% CI 1.11–3.88) [ 63 ].…”

Section: Resultsmentioning

confidence: 99%

Environmental Contaminants and Congenital Heart Defects: A Re-Evaluation of the Evidence

Nicoll

2018

IJERPH

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Congenital heart defects (CHDs) are a common birth defect of largely unknown etiology, with high fetal and neonatal mortality. A review of CHDs and environmental contaminant exposure found that meta-analyses showed only modest associations for smoking, vehicle exhaust components, disinfectant by-products and proximity to incinerators, with stronger results from the newer, larger and better quality studies masked by the typical absence of effect in older studies. Recent studies of exposure to agricultural pesticides, solvents, metals and landfill sites also showed associations. Certain contaminants have been associated with certain CHDs, with septal defects being the most common. Frequent methodological problems include failure to account for potential confounders or maternal/paternal preconception exposure, differences in diagnosing, defining and classifying CHDs, grouping of defects to increase power, grouping of contaminants with dissimilar mechanisms, exclusion of pregnancies that result in death or later life diagnosis, and the assumption that maternal residence at birth is the same as at conception. Furthermore, most studies use measurement estimates of one exposure, ignoring the many additional contaminant exposures in daily life. All these problems can distort and underestimate the true associations. Impaired methylation is a common mechanism, suggesting that supplementary folate may be protective for any birth defect.

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Section: Resultsmentioning

confidence: 99%

Environmental Contaminants and Congenital Heart Defects: A Re-Evaluation of the Evidence

Nicoll

2018

IJERPH

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“…Incidence of infection or threatened abortion during first trimester of pregnancy was higher in the CHD group than the non‐CHD group in our study. Previous studies indicate that maternal environmental exposures, occupation and perinatal diseases, medication use are dominant risk factors associated with CHD . The underlying reason of no significant difference of maternal BMI, age, smoking status between two groups may be the incomplete investigation of early pregnancy exposure.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies indicate that maternal environmental exposures, occupation and perinatal diseases, medication use are dominant risk factors associated with CHD. [28][29][30] The underlying reason of no significant difference of maternal BMI, age, smoking status between two groups may be the incomplete investigation of early pregnancy exposure. AHA and American College of Cardiology suggest that patients considered at high risk should be offered detailed fetal echocardiography 31,32 , it is consistent with our experience.…”

Section: Discussionmentioning

confidence: 99%

Is echocardiography necessary for all single umbilical artery fetuses? A retrospective study in a selected Chinese population

Wang

Xin

et al. 2019

J of Obstet and Gynaecol

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Aim Previous evidence on the relationship between single umbilical artery (SUA) and congenital heart disease (CHD) is controversial. We thus conducted a retrospective study to explore the potential risk factors associated with CHD in SUA fetuses, and verify if all these SUA fetuses should be referred for detail fetal echocardiography. Methods We reviewed medical records of SUA fetuses referred to Xinhua Hospital for fetal echocardiography between September 2009 and February 2014. All the pregnancies were divided into two groups of CHD and non‐CHD according to the results of fetal echocardiography. The maternal and fetal characteristics were compared via χ2 test and Fishers’ test. Furthermore, Poisson regression was used to analyze the risk factors associated with CHD in SUA pregnancies. Results Nineteen CHD cases (12.5%) were detected among 152 SUA fetuses, all with abnormal cardiac views during obstetric screening ultrasound (P < 0.001). χ2 test showed that abnormal cardiac screening findings, extracardiac abnormality and infection or threatened abortion during first trimester were significantly associated with prenatal detection of CHD (P < 0.001). Multivariable Poisson regression after adjustment found that SUA fetuses with extracardiac abnormality had 4.74 (95% confidence interval: 1.89, 11.90) times higher risk of CHD. Conclusion Incidence of CHD was higher in SUA cases, and CHD fetuses could be screened efficiently by abnormal cardiac screening during obstetric screening ultrasound. SUA fetuses with extracardiac abnormality and maternal risk factors have higher risk of CHD, and should be strongly recommended for fetal echocardiography. In contrast, SUA fetuses without above situations might only need routine obstetric follow‐up.

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“…can cause cell damage and necrosis cells. Exposure to lead and aluminum may increase the risk of congenital heart disease (CHD) occurrence, and may lead to a decline in the activity of antioxidant enzymes (Liu et al, 2018). Sugiharto et al, (2018) observed that curcumin as an antioxidant can restore the damaged cells.…”

Section: Determination Of Lead Concentration In Livermentioning

confidence: 99%

Antioxidant Activities of Curcumin to Mda Blood Serum Concentration and Lead Levels in Liver of Mice

Sugiharto

Darmanto

Wahyuningsih

et al. 2019

MJS

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Human and animals can accidentally be exposed to heavy metals from the environment such as lead (Pb). Lead may induce oxidative stress. It can increase the production of free radicals, and induces several responses in physiological and biochemical functions of the body. Curcumin, a major component of turmeric, is commonly used as a spice and in traditional medicine. The objective of this research was to evaluate the antioxidant activities of curcumin in mice that were exposed to lead. Research was conducted using twenty five male mice, which were grouped into five treatments: P1 (control), P2 (Pb 75 mg/kg BW), P3 (Pb 150 mg/kg BW), P4 (Pb 75 mg/kg BW + curcumin 20 ppm), P5 (Pb 150 mg/kg BW + curcumin 20 ppm). The results showed that antioxidant activities of curcumin was very strong with an IC-50 was 9.0 ppm. Pb exposure increased MDA level (17.143-17.891 µM) and Pb level in the liver (0.070-0.071 mg/kg BW). Administration of curcumin 20 ppm have the potential to reduced MDA level (14.592-15.714 µM) and reduce Pb levels (0.035-0.038 mg/kg BW).

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The effects of lead and aluminum exposure on congenital heart disease and the mechanism of oxidative stress

Cited by 54 publications

References 38 publications

Environmental Contaminants and Congenital Heart Defects: A Re-Evaluation of the Evidence

Environmental Contaminants and Congenital Heart Defects: A Re-Evaluation of the Evidence

Is echocardiography necessary for all single umbilical artery fetuses? A retrospective study in a selected Chinese population

Antioxidant Activities of Curcumin to Mda Blood Serum Concentration and Lead Levels in Liver of Mice

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