The effects of levamisole on some functions of mouse macrophages after in vitro and in vivo administration

Lysosomal enzymes and metabolic activity of polymorphonuclear leukocytes from patients with systemic lupus erythematosus and from experimental animals after levamisole treatment

“…MIKULiKOV~, and TRNAVSK~" [31] also found that preincubation of human PMNs with levamisole (10 -3 to l0 -4 M concentrations) resulted in a decrease of lysosomal enzyme release induced by monosodium crystals. On the other hand CRUCHAUD et al [32] observed an increased lysosomal enzyme release after the incubation of mouse peritoneal macrophages with 1 and 5 mM levamisole and SYMOENS et al [1] also reported a stimulation of lysosomal enzyme release by levamisole. In our experiments (Table 3) we were not able to prove any significant effect of levamisole on the release of lysosomal en-zymes from human PMNs after its induction by zymosan particles.…”

Traxanox augments immune response to lipopolysaccharide in inbred mice: Role of macrophages.

“…1 and 2) may be due to the enhancement of the function of B cells and/or macrophages. There is some evidence that LMS may serve to improve antigen processing and presentation by macrophages (16) and not to stimulate B cell-enriched spleen cells (17). Recently, we found that traxanox sodium has a capacity to restore the cell-mediated immunity of the mice suppressed by the pretreatment with cyclophosphamide or car rageenan (6).…”