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of effector-regulator recognition or the mechanisms of control.However, these phenomena are best explained by the immunological network of Jerne [ 11. The antigen specificity we demonstrate would be the product of specific interactions between idiotypic effector cells and their anti-idiotypic regulators. Thus, we propose that the antagonistic relationship between the idiotypic effector clone and the regulatory antiidiotypic clone may be characterized by regular, cyclic behavior, perhaps in the form of Lotka-Volterra oscillations [ 171, even in the naive individual.The synthesis of cyclic AMP by mouse peritoneal macrophages in response to stimulation by isoproterenol was studied as a function of drug concentration, incubation time and cell density. Cyclic AMP levels of macrophages increased 3 to 3.5 times over the control level 20 sec after the addition of

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